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Total 243 results found since Jan 2013.

Advances in pediatrics in 2014: current practices and challenges in allergy, gastroenterology, infectious diseases, neonatology, nutrition, oncology and respiratory tract illnesses
Abstract Major advances in the conduct of pediatric practice have been reported in the Italian Journal of Pediatrics in 2014. This review highlights developments in allergy, gastroenterology, infectious diseases, neonatology, nutrition, oncology and respiratory tract illnesses. Investigations endorse a need to better educate guardians and improve nutritional management in food allergy. Management of hyperbilirubinemia in neonates and of bronchiolitis have been improved by position statements of scientific societies. Novel treatments for infant colic and inflammatory bowel diseases have emerged. Studies suggest th...
Source: Italian Journal of Pediatrics - October 31, 2015 Category: Pediatrics Source Type: research

Ezetimibe provides incremental reduction in risk for cardiovascular events and need for revascularisation following an acute coronary syndrome
Commentary on: Cannon CP, Blazing MA, Giugliano RP, et al., IMPROVE-IT Investigators. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med 2015;372:2387–97. Context Use of statin therapy to treat dyslipidemia in patients with established coronary artery disease is the standard of care worldwide. Given the negative results of a number of trials that tested the use of adjuvant lipid-lowering therapies against a statin background, there has been great scepticism about whether or not non-statin drugs provide incremental benefit.1–3 Ezetimibe inhibits the absorption of both dietary and bili...
Source: Evidence-Based Medicine - September 24, 2015 Category: Internal Medicine Authors: Toth, P. P. Tags: Health policy, Epidemiologic studies, Genetics, Immunology (including allergy), Vaccination / immunisation, Stroke, Diet, Ischaemic heart disease, Health economics, Health service research, Lipid disorders Therapeutics/Prevention Source Type: research

Sean Parker Just Gave $600 Million To Help Solve The World's Biggest Problems
While it’s not unusual for tech billionaires to commit to philanthropic efforts these days, it would be tricky to find an analog for the approach being taken by former Facebook President Sean Parker with his newly announced foundation. That’s because Parker is aiming to bring a “go big or go home” Silicon Valley-informed approach to his San Francisco-based Parker Foundation, which has been established through a $600 million gift from the Napster cofounder and Spotify board member. The foundation will focus on three core areas where Parker thinks real progress can be made: civic engagement, global public health and ...
Source: Healthy Living - The Huffington Post - June 24, 2015 Category: Consumer Health News Source Type: news

Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.
Abstract The ability to identify immunogenic determinants that activate T-cells is important for the development of new vaccines, allergy therapy and protein therapeutics. In silico MHC-II binding prediction algorithms are often used for T-cell epitope identification. To understand how well those programs predict immunogenicity, we computed HLA binding to peptides spanning the sequence of PE38, a fragment of an anti-cancer immunotoxin, and compared the predicted and experimentally identified T-cell epitopes. We found that the prediction for individual donors did not correlate well with the experimental data. Furth...
Source: Journal of Immunological Methods - June 6, 2015 Category: Allergy & Immunology Authors: Mazor R, Tai CH, Lee B, Pastan I Tags: J Immunol Methods Source Type: research

Peptide vaccines for cancer therapy.
Authors: Cerezo D, Pena MJ, Mijares M, Martinez G, Blanca I, De Sanctis JB Abstract For around four decades, vaccines of different kinds have been developed to treat different types of cancer. However, promising results encountered in the early phase contrasted with the results recorded in clinical studies. Recent discoveries in the vaccine field, adjuvants and delivery systems, and antigen presentation have lead to new patented approaches. The current review is focused on general description of peptide vaccines involving cancer antigen presentation, specific immune response, cell death dependent pathways, and targ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Personalized melanoma vaccine evokes immune response
A customized vaccine targeting patient-specific, tumor neoantigens evoked an immune response in three adults with advanced cutaneous melanoma in a proof-of-principle study that paves the way for a phase I trial. The data are “too premature to conclude that the treatment had any therapeutic benefit...
Source: Skin and Allergy News - April 2, 2015 Category: Dermatology Tags: SAN Journals SAN Clinical News SAN News SAN SCN: Melanoma ONCR Journals ONCR News ONCR Melanoma & Skin Cancers FPN Journals Source Type: news

Vaccine pioneer begins reign as acting director of the National Cancer Institute
Dr. Douglas Lowy has been officially named acting director of the National Cancer Institute, following the March 31 exit of Dr. Harold Varmus as director. Dr. Lowy had been serving as the National Cancer Institute’s deputy director since July 2010, according to a <a...
Source: Skin and Allergy News - April 1, 2015 Category: Dermatology Tags: ONCR News ONCR Gynecologic FPN News FPN Oncology IMN Oncology SAN Clinical News SAN News PED News Source Type: news

Type-specific HPV prevalence in invasive cervical cancer in the UK prior to national HPV immunisation programme: baseline for monitoring the effects of immunisation
Conclusions The prevalence of HPV 16 and/or 18 was high in all UK countries and highest in those diagnosed at a younger age. The UK is well placed to monitor the impact of HPV vaccination on type-specific HPV prevalence in cervical disease.
Source: Journal of Clinical Pathology - January 20, 2015 Category: Pathology Authors: Mesher, D., Cuschieri, K., Hibbitts, S., Jamison, J., Sargent, A., Pollock, K. G., Powell, N., Wilson, R., McCall, F., Fiander, A., Soldan, K. Tags: Immunology (including allergy), Cervical cancer, Cervical screening, Gynecological cancer Original article Source Type: research

MPLA shows attenuated pro‐inflammatory properties and diminished capacity to activate mast cells in comparison to LPS
ConclusionsCompared to LPS, MPLA induced a qualitatively similar, but less potent pro‐inflammatory immune response, but was unable to activate human or mouse MCs.This article is protected by copyright. All rights reserved.
Source: Allergy - January 1, 2015 Category: Allergy & Immunology Authors: Stefan Schülke, Adam Flaczyk, Lothar Vogel, Nicolas Gaudenzio, Isabelle Angers, Bettina Löschner, Sonja Wolfheimer, Ingo Spreitzer, Salman Qureshi, Mindy Tsai, Stephen Galli, Stefan Vieths, Stephan Scheurer Tags: Original Article Source Type: research

Uh Oh, It's Flu Season! What You Need to Know About Flu Vaccination
Media reports from just about every corner of the country are cautioning that Americans could be in for a particularly intense flu season this year, with many medical experts encouraging folks not to delay getting their flu shots. The flu season is not only here -- it could last until as late as May of next year according to the CDC. With this in mind, it is helpful to review a few basics that could help keep you, your family and your friends and neighbors feeling at their best during this winter's seasonal outbreaks of the flu. Who's at Risk? The flu is a respiratory infection that can cause serious, sometimes life-thr...
Source: Healthy Living - The Huffington Post - December 12, 2014 Category: Consumer Health News Source Type: news

North Texas Fracking Zone Sees Growing Health Worries
This story was published by The Center for Public Integrity, a nonprofit, nonpartisan investigative news organization in Washington, D.C. DALLAS—Propped up on a hospital bed, Taylor Ishee listened as his mother shared a conviction that choked her up. His rare cancer had a cause, she believes, and it wasn’t genetics. Others in Texas have drawn the same conclusions about their confounding illnesses. Jana DeGrand, who suffered a heart attack and needed both her gallbladder and her appendix removed. Rebecca Williams, fighting off unexplained rashes, sharp headaches and repeated bouts of pneumonia. Maile Bush, who needed ...
Source: Science - The Huffington Post - December 11, 2014 Category: Science Source Type: news

Newly approved Gardasil 9 vaccine adds 20% more coverage against cervical cancer
The Food and Drug Administration has approved a new version of the Gardasil vaccine that protects against five more human papillomavirus types that cause about 20% of cervical cancers, the agency announced on Dec. 10. The new vaccine, which is called Gardasil 9, “has the potential to prevent...googletag.display('div-gpt-ad-cta');
Source: Skin and Allergy News - December 10, 2014 Category: Dermatology Tags: FPN FDA & CDC FPN News FPN Child Adolescent Medicine FPN Men's Health FPN Women's Health IMN FDA IMN News IMN Adolescent Medicine Source Type: news

Vitamin D Receptor Signals Regulate Effector and Memory CD8 T Cell Responses to Infections in Mice Nutritional Immunology
Conclusion: Our data show a previously unrecognized impact of vitamin D deficiency on the quantity, quality, breadth, and location of CD8 T cell immunity to acute viral and bacterial infections.
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Yuzefpolskiy, Y., Baumann, F. M., Penny, L. A., Studzinski, G. P., Kalia, V., Sarkar, S. Tags: Nutritional Immunology Source Type: research

Immunisation against HPV in girls with intellectual disabilities
Since September 2008 in the UK, immunisation against human papillomavirus (HPV) has been routinely offered to all girls aged 12–13 years as part of the childhood immunisation programme. It has been shown in previous research, that children attending schools for children and young people with intellectual disability are less likely to receive routine vaccines compared with non-disabled peers.1 Unpublished data from an audit carried out in the Portsmouth district suggests similar issues for HPV vaccination. This paper looks at what we know about HPV infection and the risks to individuals with intellectual disabili...
Source: Archives of Disease in Childhood - November 13, 2014 Category: Pediatrics Authors: MacLeod, R., Tuffrey, C. Tags: Oncology, Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Cervical cancer, Cervical screening, Adolescent health, Child and adolescent psychiatry (paedatrics), Child health, Disability, Screen Source Type: research

HPV vaccine rates perpetuate racial and geographic cancer disparities
SAN ANTONIO – Girls who live in states with higher rates of cervical cancer incidence and mortality are less likely to receive the human papilloma virus vaccine, researchers reported at a meeting on disparities in cancer health care held by the American Association for Cancer...
Source: Skin and Allergy News - November 11, 2014 Category: Dermatology Tags: FPN Journals FPN News FPN Child & Adolescent Medicine FPN Infectious Diseases IMN Journals IMN News Source Type: news