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Total 243 results found since Jan 2013.
UCLA scientists show how to amplify or stifle signals for immune responses
T cells, the managers of our immune systems, spend their days shaking hands with another type of cell that presents small pieces of protein from pathogens or cancerous cells to the T cell. But each T cell is programmed to recognize just a few protein pieces, known as antigens, meaning years can go by without the T cell, or its descendants, recognizing an antigen.When the T cell does recognize an antigen, it gives the cell presenting the antigen a “hug,” so to speak, instead of a handshake. This initial interaction causes the T cell to search nearby to find other cells that are presenting the same antigen to give them â...
Source: UCLA Newsroom: Health Sciences - March 7, 2017 Category: Universities & Medical Training Source Type: news
Our news predictions for 2017
Climate change continues to impact on public health
Despite what many commenters have said in 2016, climate change is real and is ongoing. That's the thing about science. Just because you don't believe in it, it doesn't go away.
In 2016 we have seen evidence of the impact of climate change in a number of different ways.
There was an anthrax outbreak in northern Russia as warm weather caused the release of previously frozen deadly anthrax spores.
And many experts think that the spread of the Zika virus across much of the Americas was made possible, in part, by changes in temperature that created environments in which the ...
Source: NHS News Feed - December 30, 2016 Category: Consumer Health News Tags: QA articles Special reports Source Type: news
Checkpoint immunotherapy: good for cancer therapy, bad for rheumatic diseases
The goal of harnessing the immune system to fight cancer is not new; it dates back 125 years to when William Coley advocated that the body's response to infection could have anti-tumoural effects.1 However, decades of efforts using vaccines and immune stimulant therapies to harness the immune system to fight tumours have had limited success and at times have been fraught with serious adverse outcomes. Recently, drugs blocking negative immune checkpoint pathways have shown remarkable clinical activity in various solid tumours.2 Several agents targeting two such negative checkpoints, the programmed death-1 (PD-1) pathwa...
Source: Annals of the Rheumatic Diseases - December 8, 2016 Category: Rheumatology Authors: Calabrese, L., Velcheti, V. Tags: Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Editorials Source Type: research
ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12 ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12
The American Cancer Society has endorsed CDC guidelines for HPV vaccinations that recommend girls and boys ages 11 to 12 should receive the vaccine. Medscape Medical News
Source: Medscape Allergy Headlines - July 19, 2016 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12
The American Cancer Society has endorsed CDC guidelines for HPV vaccinations that recommend girls and boys ages 11 to 12 should receive the vaccine. Medscape Medical News
Source: Medscape Allergy Headlines - July 19, 2016 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Incidence of HPV-associated cancers on the rise
The incidence of human papillomavirus–associated cancers is increasing in the United States, but many of these cases could be prevented by the HPV vaccine, investigators from the Centers for Disease Control and Prevention report.
Between 2008 and 2012 the incidence of HPV-associated cancers was...
Source: Skin and Allergy News - July 12, 2016 Category: Dermatology Source Type: news
Hanger: Incidence of HPV-associated cancers on the rise
The incidence of human papillomavirus–associated cancers is increasing in the United States, but many of these cases could be prevented by the HPV vaccine, investigators from the Centers for Disease Control and Prevention report.
Between 2008 and 2012 the incidence of HPV-associated cancers was...
Source: Skin and Allergy News - July 12, 2016 Category: Dermatology Source Type: news
A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 Responses In Vitro.
Conclusion. Conjugation of MPLA and antigen enhanced the immune response compared to the mixture of both components. Due to the nonbiased boost of Ova-specific Th2 and Th17 responses while also inducing Th1 responses, this fusion protein may not be a suitable vaccine candidate for allergy treatment but may hold potential for the treatment of other diseases that require a strong stimulation of the host's immune system (e.g., cancer).
PMID: 27340679 [PubMed - in process]
Source: Journal of Immunology Research - June 26, 2016 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Cells to Society: Women's Empowerment / Nurse Scientists / Research News
This study investigates the patterns and factors associated with persistent high cotinine concentrations in a sample of urban children with asthma who had frequent emergency department visits.
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Source: Johns Hopkins University and Health Systems Archive - June 15, 2016 Category: Nursing Source Type: news
Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant.
Abstract
TH2-biased immune responses are associated with inadequate protection against some pathogens and with cancer, colitis, asthma and allergy. Since most currently used vaccine adjuvants induce a TH2-biased response, this has led to interest in developing adjuvants capable of activating TH1 immunity and modulating existing TH2 responses. Immunotherapies to shift immune responses from TH2 to TH1 have generally required prolonged immunization protocols and have not induced effective TH1 responses. We have demonstrated that nanoscale emulsions (NE), a novel mucosal adjuvant, induce robust IgA and IgG antibody re...
Source: Vaccine - June 13, 2016 Category: Allergy & Immunology Authors: Bielinska AU, O'Konek JJ, Janczak KW, Baker JR Tags: Vaccine Source Type: research
Id: 67: henoch-schonlein prpura with a negative skin biopsy
Conclusion
Although HSP patients mostly range from 4–7 years old it can still presents in adolescent age group. Non-thrombocytopenic palpable purpura with multi-organ involvement (gastrointestinal, skin and joints) should make one consider the diagnosis. skin biopsy should be taken less than 24 hrs from the presentation because in more chronic lesions, vessel damage leads to nonspecific leakage of all isotypes of immunoglobulin.
Abstract ID: 67 Figure 1
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Akbar, N., Akbar, S., Kubbara, A. Tags: Rheumatology/Immunology/Allergy Source Type: research
T Follicular Helper (Tfh) Cells in Normal Immune Responses and in Allergic Disorders
This article is protected by copyright. All rights reserved.
Source: Allergy - March 10, 2016 Category: Allergy & Immunology Authors: Gilda Varricchi, James Harker, Francesco Borriello, Gianni Marone Hon, Stephen R. Durham, Mohamed H. Shamji Tags: Review Source Type: research
Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy
Conclusions: These data suggest that low doses of 5-FU have no adverse effects on DC maturation and function, and the efficacy of DC-based cancer immunotherapy may be greatly enhanced by combining it with suboptimal doses of 5-FU.Int Arch Allergy Immunol 2015;168:122-130
Source: International Archives of Allergy and Immunology - December 18, 2015 Category: Allergy & Immunology Source Type: research
Advances in pediatrics in 2014: current practices and challenges in allergy, gastroenterology, infectious diseases, neonatology, nutrition, oncology and respiratory tract illnesses
Major advances in the conduct of pediatric practice have been reported in the Italian Journal of Pediatrics in 2014. This review highlights developments in allergy, gastroenterology, infectious diseases, neonatology, nutrition, oncology and respiratory tract illnesses. Investigations endorse a need to better educate guardians and improve nutritional management in food allergy. Management of hyperbilirubinemia in neonates and of bronchiolitis have been improved by position statements of scientific societies. Novel treatments for infant colic and inflammatory bowel diseases have emerged. Studies suggest the diagnostic utilit...
Source: Italian Journal of Pediatrics - October 31, 2015 Category: Pediatrics Authors: Carlo CaffarelliFrancesca SantamariaSilvia CesariElisa SciorioCarlotta Povesi-DascolaSergio Bernasconi Source Type: research
