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Therapy: Stem Cell Therapy
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Total 1246 results found since Jan 2013.
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
This study aimed to assess the T cell receptor (TCR) repertoire diversity in CD4+ cells of patients with hematological malignancies who received allogeneic or autologous HSCT. The diversity of the TCR repertoire was evaluated in 13 patients with hematologic malignancies before and four months after HSCT. Amino acid changes in the 25 Vβ families were evaluated using Spectratyping and data were presented as Hamming distance (HD). HD more than 20% was considered a change in TCR repertoire after HSCT. The mean HD was significantly changed after transplantation in all Vβ gene families, with most amino acid changes in p4 and p...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Fahimeh Zamani Reza Mirfakhraie Sayyed Reza Safaee Nodehi Yaghoub Mollaei-Kandelous Hossein Jafari Mohammad Farahmand Farhad Rezaei Majid Teymoori-Rad Abolfazl Movafagh Source Type: research
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Karo-Atar et al (J Exp Med 2022;219:e20212311; https://doi.org/10.1084/jem.20212311) discovered that helminths modulate intestinal epithelial stem cell fate to subvert host defenses. More specifically, murine infection with Heligmosomoides polygyrus bakeri (Hpb) reverted the intestinal stem cell (ISC) compartment into a pro-regenerative fetal-like state characterized by the expansion of revival stem cells, a transient injury-induced ISC population. Expansion of revival stem cells depended on helminth-derived secretory products, but not host-derived immune signals, and inhibited type 2 cytokine-driven differentiation of exp...
Source: Journal of Allergy and Clinical Immunology - November 1, 2022 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Source Type: research
Isolation and in vitro Expansion of Regulatory T Cells from β-Thalassemia Major Kids and in vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines
Conclusion: Tregs isolated from beta-TM patients have poorer inhibitory performance than Tregs isolated from healthy individuals. Also, we concluded that rapamycin stabilizes the Treg population by inhibiting the production of IL-17, all necessitating the administration of appropriate immunosuppressive drugs in patients receiving Treg therapy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - October 20, 2022 Category: Allergy & Immunology Source Type: research
A fully human anti-c-Kit monoclonal antibody 2G4 inhibits proliferation and degranulation of human mast cells
Mol Cell Biochem. 2022 Sep 15. doi: 10.1007/s11010-022-04557-3. Online ahead of print.ABSTRACTGiven that mast cells are pivotal contributors to allergic diseases, various allergy treatments have been developed to inhibit them. Omalizumab, an anti-immunoglobulin E antibody, is a representative therapy that can alleviate allergy symptoms by inhibiting mast cell degranulation. However, omalizumab cannot reduce the proliferation and accumulation of mast cells, which is a fundamental cause of allergic diseases. c-Kit is essential for the proliferation, survival, and differentiation of mast cells. Excessive c-Kit activation trig...
Source: Molecular and Cellular Biochemistry - September 15, 2022 Category: Biochemistry Authors: Kwang-Hyeok Kim Jin-Ock Kim Sang Gyu Park Source Type: research
Stem cell factor/mast cell/CCL2/monocyte/macrophage axis promotes Coxsackievirus B3 myocarditis and cardiac fibrosis by increasing Ly6C < sup > high < /sup > monocyte influx and fibrogenic mediators production
Immunology. 2022 Jul 31. doi: 10.1111/imm.13556. Online ahead of print.ABSTRACTMast cells (MCs), central players in allergy and parasitic infections, play key roles in inflammation and fibrosis. Here, the impact of MCs on the progression of Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) and fibrosis was investigated using MC-deficient KitW-sh mice. Viral titres, cellular infiltrates and heart pathologies were evaluated and compared with wild-type (WT) mice during acute CVB3 infection of C57BL/6 mice. CVB3 infection induced an increased accumulation and degranulation of MCs in the hearts of mice during acute infec...
Source: Immunology - September 2, 2022 Category: Allergy & Immunology Authors: Yuan Luo Hongkai Zhang Jie Yu Lin Wei Min Li Wei Xu Source Type: research
