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Therapy: Stem Cell Therapy

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Total 1246 results found since Jan 2013.

How do bats live with so many viruses? New bat stem cells hint at an answer
Compared with other mammals, bats are notorious for hosting more viruses that are dangerous to people but not themselves. It’s an oddity that’s drawn renewed attention since COVID-19 broke out in humans—many scientists suspect the coronavirus SARS-CoV-2 leaped from bats into people, directly or via an intermediate host. Seeking to create large quantities of bat tissue to help study why the flying animals are so virus-friendly, a research team now reports it has transformed adult bat cells into versatile stem cells that can be coaxed to form many kinds of tissue . The advance, described today in Cell ...
Source: Science of Aging Knowledge Environment - February 21, 2023 Category: Geriatrics Source Type: research

Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling
Type 2 cytokines drive an airway stem cell program through IRS signaling
Source: Journal of Allergy and Clinical Immunology - February 16, 2023 Category: Allergy & Immunology Authors: Xin Wang, Nils R. Hallen, Minkyu Lee, Sachin Samuchiwal, Qihua Ye, Kathleen M. Buchheit, Alice Z. Maxfield, Rachel E. Roditi, Regan W. Bergmark, Neil Bhattacharyya, Tessa Ryan, Deb Gakpo, Soumya Raychaudhuri, Dan Dwyer, Tanya M. Laidlaw, Joshua A. Boyce, Source Type: research

Generation of Functionally Competent Eosinophils and Eosinophil Precursors Using an Induced Pluripotent Stem Cell Model
In vitro studies of normal human eosinophil development are limited by the difficulty in obtaining sufficient numbers of CD34+ stem cells from blood or bone marrow for differentiation into mature eosinophils. Human induced pluripotent stem cells (hiPSCs) have the capacity to generate large numbers of lineage-committed progenitors circumventing this problem.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Gregory Constantine, David Espinoza, Elizabeth Swain, Xiaoping Sun, Irina Maric, Gila Idelman, Patricia Fulkerson, Michelle Makiya, Calman Prussin, Amy Klion Source Type: research

Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders
Stem cell factor (SCF) and its receptor KIT play crucial roles in the differentiation, proliferation, survival, migration, and activation of mast cells. Therefore, highly selective, orally available KIT inhibitors would be beneficial for mast cell-associated diseases.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Takeo Urakami, Taisuke Takahashi, Takafumi Shimizu, William Sinko, Yuki Nakamura, Kayoko Ishimaru, Vuong Tran, Ramulu Poddutoori, Kishore Narayanan, Sivapriya Marappan, Atsuhito Nakao, Yoh Terada Source Type: research

An educational program for trainees in serving underserved primary immunodeficiency patients
Despite increasing awareness of barriers to healthcare, disparity of care in primary immune deficiency is a reality. Many of the clinical imperatives are larger in scope: political advocacy for newborn screening programs, establishing more centers of excellence in hematopoietic stem cell transplantation in impoverished areas, and combating systemic injustice. However, achieving these objectives depends on training a new generation of committed clinical immunologists.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jessica Galant-Swafford, Elizabeth George, Anna Meyer Source Type: research

Late Survival after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease in a Single-Center Cohort
Chronic granulomatous disease (CGD) is an inborn error of immunity associated with significant morbidity and mortality for which hematopoietic stem cell transplant (HSCT) is a definitive treatment. In a large single-center cohort, we examined the late survival (survival at 5 years post-HSCT) of all patients who underwent HSCT for CGD at the Children ’s Hospital of Philadelphia (CHOP).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Whitney Reid, Anne Wohlschlaeger, Brittany Adduce, Nancy Bunin, Jennifer Heimall Source Type: research

Gastrointestinal and Hepatic Manifestations of Chronic Granulomatous Disease
J Allergy Clin Immunol Pract. 2023 Jan 13:S2213-2198(23)00050-8. doi: 10.1016/j.jaip.2022.12.039. Online ahead of print.ABSTRACTChronic granulomatous disease (CGD) is a rare inborn error of immunity, resulting from a defect in nicotinamide adenine dinucleotide phosphate (NADPH) oxidation and decreased production of phagocyte reactive oxygen species. The main clinical manifestations are recurrent infections and chronic inflammatory disorders. Current approaches to management include antimicrobial prophylaxis and control of inflammatory complications. Hematopoietic stem cell transplantation (HSCT) or gene therapy can provide...
Source: Cancer Control - January 16, 2023 Category: Cancer & Oncology Authors: Alexander H Yang Brigit Sullivan Christa S Zerbe Suk See De Ravin Andrew M Blakely Martha M Quezado Beatriz E Marciano Jamie Marko Alexander Ling David E Kleiner John I Gallin Harry L Malech Steven M Holland Theo Heller Source Type: research

Specific Clinical and Immunological Changes Following Mesenchymal Stem Cell Transplantation in COVID-19-induced Acute Respiratory Distress Syndrome Patients: A Phase-I Clinical Trial
This study evaluated the safety and efficacy of three times transplantation of umbilical cord-derived MSCs (UC-MSCs) in terms of specific immunological and clinical changes in mild-to-moderate COVID-19-induced ARDS patients. In this single-center, open-label, phase 1 clinical trial, 20 patients diagnosed with COVID-19 and mild-to-moderate ARDS were included and were divided into two groups: a control group receiving standard care and an intervention group receiving UC-MSC in addition to standard care. Three consecutive intravenous transplants of UC-MSC (1× cells/kg body weight per each transplant) were performed in the in...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Najmeh Kaffash Farkhad Alireza Sedaghat Hamidreza Reihani Amir Adhami Moghadam Ahmad Bagheri Moghadam Nayereh Khadem Ghaebi Mohammad Ali Khodadoust Amin Reza Nikpoor Jalil Tavakol Afshari Source Type: research