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Therapy: Stem Cell Therapy

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Total 1246 results found since Jan 2013.

Cancers, Vol. 15, Pages 4619: Repurposing Clemastine to Target Glioblastoma Cell Stemness
hristopher J. Pirozzi Yiping He Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing PDGFRA amplification. These effects on BTICs were accompanied by altered gene expression profiling indicative of their more differentiated states, resonating with the activity of clemastine in promoting the differentiation of normal oligodendrocyte progenitor cells (OPCs) into mat...
Source: Cancers - September 18, 2023 Category: Cancer & Oncology Authors: Michael A. Sun Rui Yang Heng Liu Wenzhe Wang Xiao Song Bo Hu Nathan Reynolds Kristen Roso Lee H. Chen Paula K. Greer Stephen T. Keir Roger E. McLendon Shi-Yuan Cheng Darell D. Bigner David M. Ashley Christopher J. Pirozzi Yiping He Tags: Article Source Type: research

Impact of newborn screening for SCID on the management of congenital athymia
Newborn screening (NBS) programmes for severe combined immunodeficiency (SCID) facilitate early SCID diagnosis and promote early treatment with haematopoietic stem cell transplantation, resulting in improved clinical outcomes. Infants with congenital athymia are also identified through NBS due to severe T-cell lymphopaenia. With the expanding introduction of NBS programmes, referrals of athymic patients for treatment with thymus transplantation have recently increased at Great Ormond Street Hospital (GOSH), London, United Kingdom.
Source: Journal of Allergy and Clinical Immunology - September 5, 2023 Category: Allergy & Immunology Authors: Evey Howley, Zainab Golwala, Matthew Buckland, Federica Barzaghi, Sujal Ghosh, Scott Hackett, Rosie Hague, Fabian Hauck, Ursula Holzer, Adam Klocperk, Minna Koskenvuo, Nufar Marcus, Antonio Marzollo, Malgorzata Pac, Jan Sinclair, Carsten Speckmann, Maarja Source Type: research

Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function
J Cell Mol Med. 2023 Aug 21. doi: 10.1111/jcmm.17924. Online ahead of print.ABSTRACTShort-chain fatty acid butyrate is produced from the bacterial fermentation of indigestible fiber in the intestinal lumen, and it has been shown to attenuate lung inflammation in murine asthma models. Mast cells (MCs) are initiators of inflammatory response to allergens, and they play an important role in asthma. MC survival and proliferation is regulated by its growth factor stem cell factor (SCF), which acts through the receptor, KIT. It has previously been shown that butyrate attenuates the activation of MCs by allergen stimulation. Howe...
Source: Molecular Medicine - August 21, 2023 Category: Molecular Biology Authors: Ravindra Gudneppanavar Emma Elizabeth Sabu Kattuman Lakshminarayan Reddy Teegala Erik Southard Ramakumar Tummala Bina Joe Charles K Thodeti Sailaja Paruchuri Source Type: research

Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, systemic hyperinflammatory disorder. Familial hemophagocytic lymphohistiocytosis (FHL) comprises a group of rare autosomal-recessive diseases caused by loss-of-function mutations in genes encoding key proteins involved in the cytolytic vesicle-mediated killing by natural killer and T cells.1-4 The inability of these cytotoxic lymphocytes to efficiently lyse target cells, including antigen-presenting cells, leads to their continuous stimulation, hyperactivation, and massive IFN- γ secretion.
Source: Journal of Allergy and Clinical Immunology - August 16, 2023 Category: Allergy & Immunology Authors: Viviane Dettmer-Monaco, Kristoffer Wei ßert, Sandra Ammann, Gianni Monaco, Lei Lei, Linda Gräßel, Manuel Rhiel, Julia Rositzka, Masako M. Kaufmann, Kerstin Geiger, Geoffroy Andrieux, Jessica Lao, Gudrun Thoulass, Christoph Schell, Melanie Boerries, Ann Source Type: research

Gene editing of hematopoietic stem cells restores T cell response in familial hemophagocytic lymphohistiocytosis
Source: Journal of Allergy and Clinical Immunology - August 16, 2023 Category: Allergy & Immunology Authors: Viviane Dettmer-Monaco, Kristoffer Wei ßert, Sandra Ammann, Gianni Monaco, Lei Lei, Linda Gräßel, Manuel Rhiel, Julia Rositzka, Masako M. Kaufmann, Kerstin Geiger, Geoffroy Andrieux, Jessica Lao, Gudrun Thoulass, Christoph Schell, Melanie Boerries, Ann Source Type: research

Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID-19 Patients
This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue-derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. The frequency of CD4+CD25+CD127- Tregs was significantly hig...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Morteza Motallebnezhad Ali Hazrati Hadi Esmaeili Gouvarchin Ghaleh Nematollah Jonaidi-Jafari Sanaz Abbaspour-Aghdam Kosar Malekpour Mehdi Yousefi Hossein Samadi Kafil Farhad Jadidi-Niaragh Leila Roshangar Hamed Valizadeh Morteza Izadi Majid Ahmadi Source Type: research