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Therapy: Statin Therapy
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Total 77 results found since Jan 2013.
DDIWAS: High-throughput electronic health record-based screening of drug-drug interactions
ConclusionsIn this proof-of-concept study, we demonstrate the value of incorporating information mined from existing allergy lists to detect DDIs in a real-world clinical setting. Since allergy lists are routinely collected in EHRs, DDIWAS has the potential to detect and validate DDI signals across institutions.
Source: Journal of the American Medical Informatics Association - March 13, 2021 Category: Information Technology Source Type: research
Effect of Prescription Drugs on Anaphylaxis Severity and Symptoms
Anaphylactic reactions are medical emergencies presenting with varying levels of severity, which may be influenced by drug intake. We aimed to assess the severity of anaphylaxis in patients taking statins, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, tricyclic antidepressants as well as proton-pump inhibitors.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Sofianne Gabrielli, Ann Clarke, Judy Morris, Jocelyn Gravel, Rodrick Lim, Edmond Chan, Ran Goldman, Andrew O, Jennifer Gerdts, Derek Chu, Julia Upton, Adam Bretholz, Christine McCusker, Xun Zhang, Moshe Ben-Shoshan, Laura May Miles Source Type: research
PI3K γ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition—Moving Towards Cell Specific PI3K Targeting?
Mast cells are the major effector cells in immunoglobulin E (IgE)-mediated allergy. The high affinity IgE receptor FcεRI, as well as G protein-coupled receptors (GPCRs) on the mast cell surface signals to phosphoinositide 3-kinase γ (PI3Kγ) to initiate degranulation, cytokine release, and chemotaxis. PI3Kγ is therefore considered as a target for treatment of allergic disorders. However, leukocyte PI3Kγ is key to many functions in innate and adaptive immunity, and attenuation of host defense mechanisms is an expected adverse effect that complicates treatment of chronic illnesses. PI3Kγ operates as a p110γ/p84 or p110...
Source: Frontiers in Immunology - October 28, 2020 Category: Allergy & Immunology Source Type: research
Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - September 7, 2020 Category: Allergy & Immunology Authors: Ahmed, Tanvir Archie, Sabrina R. Faruk, Asef Chowdhury, Fabliha Ahmed Al Shoyaib, Abdullah Ahsan, Chowdhury Rafiqul Tags: Research article Source Type: research
Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways
AbstractAtherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause secretion of IL-1 β and IL-18. Thus, these actions may further aggravate the disease. On the other hand, some statins ca...
Source: Clinical Reviews in Allergy and Immunology - May 5, 2020 Category: Allergy & Immunology Source Type: research
Predictors of Statin Intolerance in Patients With a New Diagnosis of Atherosclerotic Cardiovascular Disease Within a Large Integrated Health Care Institution: The IMPRES Study
This study sought to increase understanding about which patients are unlikely to tolerate statin therapy. The Intermountain Healthcare's electronic data repository was queried from January 1, 1999, to December 31, 2013, to identify all adults who survived their first encounter of coronary artery disease (CAD), cerebral vascular disease, or peripheral artery disease and received statin therapy during follow-up. Statin intolerance (SI) was identified by the documentation of clinician-noted intolerance or allergy or by the use of pitavastatin. Patients were followed up for ≥3 years or until death. Of the 48,997 patients eva...
Source: Journal of Cardiovascular Pharmacology - May 1, 2020 Category: Cardiology Tags: Original Article Source Type: research
Survey finds high level of self-prescribing among doctors
Young doctors also prescribing to friends and family Related items fromOnMedica GPs need more time to treat complex needs GPs defend practice on prescribing statins Double check patients with ‘penicillin’ allergy to avoid MRSA risk Clinicians need better options if we are to stop over-medication MHRA tightens licence restrictions on valproate for women
Source: OnMedica Latest News - December 3, 2019 Category: UK Health Source Type: news
Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?
Abstract
Many observations showed that hypercholesterolemia can disrupt immune response. Statin drugs that were used for the treatment of hypercholesterolemia patients can interfere in the regulation of the immune response and cytokine secretion. The primary aim of the current study was to investigate the immune response among treatment-naïve patients with hypercholesterolemia and healthy subjects. The secondary goal of the study was to determine whether atorvastatin can reverse the detrimental effect of hypercholesterolemia on the immune system. Peripheral blood mononuclear cells (PBMCs) were isolated from 50 pa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Emruzi Z, Babaheidarian P, Arshad M, Stockinger H, Ahangari G Tags: Iran J Allergy Asthma Immunol Source Type: research
The Synergistic Effect of Fluvastatin and IFN- λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype.
This study was aimed to examine the effect of fluvastatin and IFN-ƛ in the expression of mediators involved in lipid metabolism and HCV proliferation in patients with rs12979860 CC polymorphism. Thirteen patients with HCV and five controls with rs1297986CC polymorphism were included in this study. Peripheral blood mononuclear cells (PBMCs) of patients and controls were treated by fluvastatin, IFN-λ or fluvastatin+IFN-λ. Assessment of IL-28B polymorphism, RNA extraction, and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed. The mRNA expression of sterol regulatory element-binding prote...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Farzanegan Gharabolagh A, Bamdad T, Hedayati M, Dehghan Manshadi SA Tags: Iran J Allergy Asthma Immunol Source Type: research
Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats.
This study aimed to examine the possible interaction effect of asthma on lipid profiles and evaluate the effect of rosuvastatin treatment on asthma. The animals were assigned into (1) control, (2) asthmatic, (3) hyperlipidemic, (4) asthmatic-hyperlipidemic, (5) rosuvastatin (40 mg/kg/day intraperitoneally, for 3 weeks)-treated asthmatic, (6) rosuvastatin-treated hyperlipidemic and (7) rosuvastatin-treated asthmatic-hyperlipidemic groups. Tracheal responsiveness to methacholine and ovalbumin, total and differential WBC (white blood cell) counts, and oxidative stress markers in bronchoalveolar lavage fluid (BALF) were evalua...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 11, 2019 Category: Allergy & Immunology Authors: Saadat S, Mokhtari-Zaer A, Hadjzadeh MA, Boskabady MH Tags: Iran J Allergy Asthma Immunol Source Type: research
Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons
Conclusions: The lipidome is altered in ART-treated HIV infection, and may contribute to inflammation and CVD progression. Detailed lipidomic analyses may better assess CVD risk in both HIV+ and HIV– individuals than does traditional lipid profiling.
Introduction
Both HIV infection and the use of antiretroviral therapy (ART) contribute to an increased risk for cardiovascular disease (CVD) (1, 2). Dyslipidemia is observed in HIV-infected (HIV+) individuals, and is associated with reduced levels of high-density lipoprotein (HDL) cholesterol, and elevated total (TC) cholesterol, low-density lipoprotein (...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research
Therapeutic effects of pravastatin on asthmatic airway inflammation in high fat diet induced obese mouse asthma model.
Obesity is one of factors associated with severe, uncontrolled asthma. Th17 signaling pathway is known to be associated with obese asthmatics, however effect of pravastatin on obese asthmatic airway inflammation has not been evaluated.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Hwayoung Lee, Jung Hur, Chin Kook Rhee, Ji Young Kang, Sook Young Lee Source Type: research
Focus on pros and cons of drug-based medicine
New RCGP exhibit on drugs in medicine Related items fromOnMedica Double check patients with ‘penicillin’ allergy to avoid MRSA risk Medics oppose plans to change script drugs to over the counter Make greater effort to protect children from methadone GPs defend practice on prescribing statins MHRA tightens licence restrictions on valproate for women
Source: OnMedica Latest News - November 29, 2018 Category: UK Health Source Type: news
Increased Dose and Duration of Statin Use Is Associated with Decreased Asthma-Related Emergency Department Visits and Hospitalizations
ConclusionsOur study suggests that statin use is associated with the decreased risk of asthma-related ED visits and/or hospitalizations in patients with asthma. A dose-response effect of statin use is also observed in this study. Therefore, future randomized clinical trials would be warranted to further evaluate the association.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research
Abstract 246: Single Center Study of Statin Use Among Renal Transplant Recipients Session Title: Poster Session PM
Conclusion: In this high risk cohort, a significant proportion of patients who were statin eligible including diabetics, were not prescribed statin. Less than half of renal transplant recipients had a lipid panel documented pre and post- transplant. Patterns of use of cardioprotective medications in the renal transplant population, and its relation to renal and cardiac outcomes needs further study.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Nestasie, M., Madhana Kumar, A., Doyle, M., Poornima, I. G. Tags: Session Title: Poster Session PM Source Type: research
