Focus on pros and cons of drug-based medicine

New RCGP exhibit on drugs in medicine Related items fromOnMedica Double check patients with ‘penicillin’ allergy to avoid MRSA risk Medics oppose plans to change script drugs to over the counter Make greater effort to protect children from methadone GPs defend practice on prescribing statins MHRA tightens licence restrictions on valproate for women
Source: OnMedica Latest News - Category: UK Health Source Type: news

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(MedPage Today) -- Patients with late-onset asthma, low lung function most responsive
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news
AbstractBackgroundAsthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control.ObjectiveOur aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins.MethodsSex- and age-matched subjects (10 –35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow’s milk hyp...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
DiscussionFor patients with a low-to-moderate risk of CAD, we found a significant effect of rosuvastatin on retinal microvasculature, including AVR increase, venular constriction, and arteriolar dilation after 6 –12 months of treatment.Clinical Trial registrationChinese Clinical Trial Registry identifier number ChiCTR-IOR-15006664.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
AbstractMultipronged risk management in diabetes has contributed to the recent decline in cardiovascular mortality. Few antihyperglycemic drugs have been conclusively shown to have cardioprotective effects. These include metformin, liraglutide, semaglutide, dulaglutide, and sodium-glucose cotransporter-2 inhibitors. Statins are the cornerstone of treatment for people with established coronary artery disease (CAD) or at risk of CAD. In patients with persistent low-density lipoprotein cholesterol (LDL-C) levels>  70 mg/dL, the addition of ezetimibe or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibit...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
Source: Notes from Dr. RW - Category: Internal Medicine Tags: pulmonary Source Type: blogs
ResMed (NYSE:RMD) subsidiary Propeller Health today released results from a new study exploring real-world use of rescue or controller inhalers that indicated that the majority of users did not use their inhalers properly. Results from the research were published in The Journal of Allergy and Clinical Immunology: In Practice, the Madison, Wisc.-based company said. Read the whole story on our sister site, Drug Delivery Business News The post Propeller Health study suggests 84% of asthma inhaler use performed incorrectly appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Featured Respiratory Propeller Health ResMed Inc. Source Type: news
Conclusions: We suggest that NLR, PLR, CRP, ESR, and bilirubin can be used in clinical practice for prediction of CVT in suspected patients as they are inexpensive parameters and widely available. However, further large-scale studies are required to confirm this relationship.RESUMEN la trombosis de la vena cerebral (CVT) es una causa rara pero grave de accidente cerebrovascular agudo. La inflamaci ón es un factor etiológico hipotético en CVT. Objetivo: El objetivo de este estudio fue evaluar los niveles de marcadores inflamatorios en pacientes con CVT y compararlos con los sujetos sanos. Métodos...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Authors: Vollaro A, Catania MR, Iesce MR, Sferruzza R, D'Abrosca B, Donnarumma G, De Filippis A, Cermola F, DellaGreca M, Buommino E Abstract Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have been identified in many natural products, e.g. lignans. Lignans are a sub-group of non-flavonoid polyphenols that play an active role in plants' defense against bacteria and fungi i...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
ConclusionVitamin D Deficiency was prevalent in both males and females across different age groups in the citizens of Saudi. Because of the connection between Vitamin D Deficiency and main chronic disease, it is necessary to emphasize the need to recognize Vitamin D Deficiency screening for risk factors. It may be reasonable for the nutritionists, nurses, and physicians, to encourage the community on approaches to enhance dietary Vitamin D or suggest supplementation.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
This study aims at synthesizing novel di-morpholine 1,3,5-triazine derivatives as antidiabetic agent via inhibition of dipeptidyl peptidase-4 (DPP-4). The molecules were developed via sequential nucleophilic reaction to afford target derivatives 5(a –f) and subsequently tested for inhibitory potency against DPP iso-enzymes, such as DPP-4, DPP-8, and DPP-9. The in vitro inhibition assay suggested that these derivatives prominently and selectively inhibit DPP-4 over ­DPP-8 and DPP-9. These molecules also showed no presence of cardiotoxicity, a s confirmed by no activity against human Ether-à-go-go related ge...
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research
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