Focus on pros and cons of drug-based medicine
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CONCLUSION: The use of SGLT2 inhibitors in insulin treated T2D patients resulted in reduction of HbA1c, which was associated to weight loss, cHDL increase and SBP decrease. PMID: 30503071 [PubMed - as supplied by publisher]
CONCLUSION: The results obtained show a sub-optimal adherence to treatment for the 3chronic diseases studied. Adherence increased with the number of chronic diseases, while sex, age and number of drugs did not show a consistent effect. It is necessary to investigate if there are other factors that may influence therapeutic adherence, since improving adherence may have a greater impact on health than any progress in therapies. PMID: 30503066 [PubMed - as supplied by publisher]
CONCLUSIONS: Many patients were not meeting Japanese LDL-C target levels at the time of ACS, and a large proportion of patients meeting target levels developed ACS; therefore, more stringent management and further evaluation of the target LDL-C levels is warranted in high-risk patients and those with previous history of CAD. PMID: 30518728 [PubMed - as supplied by publisher]
Publication date: Available online 8 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Minoru Gotoh, Syuji Yonekura, Toru Imai, Shinya Kaneko, Eiji Horikawa, Akiyoshi Konno, Yoshitaka Okamoto, Kimihiro OkuboAbstractBackgroundJapanese cedar (JC) pollinosis is a common allergic rhinitis in Japan. The JC pollen SLIT tablet was developed using the highest concentration of JC pollen extract.ObjectiveThis was a randomized, double-blind, placebo-controlled phase II/III trial to investigate the optimal dose of the JC pollen SLIT tablet and examine long-term efficacy and safety for 3 years w...
Publication date: Available online 8 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Mark Ballow, Tiffany Henderson, Christopher Scalchunes, R. Michael Blaese
ConclusionModerate-to-severe AD is associated with significant decrements of health utility in the US population. These data illustrate the heavy societal burden of moderate and severe AD and provide important insight for prioritization of resource allocation and cost-effectiveness research.
Conclusion: This study shows that SIM negatively affects the inflammatory and repair phases of the postinjury muscle regeneration. These findings are unique, strengthen the available knowledge on the side effects of SIM, and provide evidence showing that statin therapy is associated with an increased risk of impairment of the regenerative capacity of muscle. PMID: 30519583 [PubMed - in process]
Publication date: Available online 7 December 2018Source: Microbial PathogenesisAuthor(s): P. Chemmugil, P.T.V. Lakshmi, A. AnnamalaiAbstractStaphylococcus aureus an opportunistic pathogen, causes biofilm-associated infections like nosocomial and chronic disease, where quorum sensing plays vital role. Biofilm-associated infections are provocative due to antibiotic resistance and become major public health threat to human. Accordingly, there is an urgent need to identify novel compounds and groundbreaking methods to pervade and clear biofilm-associated infections. It has been suggested that naturally occurring small molecul...
Publication date: Available online 7 December 2018Source: Microbial PathogenesisAuthor(s): João Batista de Andrade Neto, Maria Aparecida Alexandre Josino, Cecília Rocha da Silva, Rosana de Sousa Campos, Francisca Bruna S. Aires do Nascimento, Letícia Serpa Sampaio, Lívia Gurgel do Amaral Valente Sá, Igor de Sá Carneiro, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Jacó Ricarte Lima de Mesquita, Bruno Coelho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre JúniorAbstractEmergence of methicilin resistant Staphylococcus aureus (M...