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Itraconazole Improved Bronchial Wall Thickness in Severe Persistent Asthma: A Double-blind Placebo-controlled Randomized Clinical Trial
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):1-11. doi: 10.18502/ijaai.v22i1.12000.ABSTRACTThe purpose of this study was to evaluate the effect of 8 months of treatment with itraconazole on airway wall thickness in patients with severe persistent asthma. It was a double-blind, randomized, placebo-controlled clinical trial (IRCT20091111002695N9). Seventy-five subjects with severe persistent asthma received itraconazole (100 mg), prednisolone (5 mg), or placebo twice a day for eight months in three treatment groups (n=25 in each group). The primary objective was to improve the right upper lobe apical segmental bronchus (...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Farnaz Aligolighasemabadi Majid Mirsadraee Mohammadamin Sadeghdoust Shadi Ghaffari Mohammad Sarafraz Yazdi Saeed Naghibi Amirhossein Hashemi Attar Source Type: research
Doxycycline Improves Quality of Life and Anosmia in Chronic Rhinosinusitis With Nasal Polyposis: A Randomized Controlled Trial
CONCLUSION: Doxycycline improves the quality of life in patients with CRSwNP. It also has temporarily beneficial effects in improving the sense of smell. The levels of eosinophil in the blood and nasal secretions do not affect the response to treatment. Hence, doxycycline can be used in both eosinophilic and non-eosinophilic nasal polyps.This study was registered at Iranian Registry of Clinical Trials. https://www.irct.ir/ IRCTID: IRCT20210403050817N1.PMID:36740870 | DOI:10.1177/19458924231154066
Source: American Journal of Rhinology and Allergy - February 6, 2023 Category: ENT & OMF Authors: Mohammad Nabavi Saba Arshi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Sofia Sabouri Fatima Moosavian Javad Nazari Vahid Bakrani Fatemeh Atashrazm Source Type: research
A Randomized Trial of Penicillin Skin Testing Versus 2-Step Direct Challenge for Penicillin Allergy During Pregnancy
Penicillins are first-line therapy for peripartum prophylaxis in Group B streptococcal-colonized women, making delabeling of PCN allergy in this population particularly important. There is scant data regarding the safety of direct challenges in penicillin-allergic pregnant women.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Allison Ramsey, S. Shahzad Mustafa Source Type: research
Alanine scanning of IgE-binding to the N-terminal epitope of Ara h 2 reveal critical amino acids
IgE binding to linear peptides of the N-terminal epitope (epitope 1: DRRCQSQLERAN) of Ara h 2 correlates with sensitivity to challenge in infants with peanut allergy and may be important for tree nut and peanut cross reactivity.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Joshua Bernstein, Nicole Canon, Catherine Schein, Werner Braun, Surendra Negi, Marina Pozzoli, Xueni Chen, Stephen Dreskin Source Type: research
The clinical and laboratory findings of infants with atopic dermatitis during diagnosis and follow-up
Conclusions. Food allergy is more common in the early-onset and moderate/severe atopic dermatitis. Accurate diagnosis of food allergy is necessary to increase the success of treatment and to prevent unnecessary diets.PMID:36637173 | DOI:10.23822/EurAnnACI.1764-1489.281
Source: European Annals of Allergy and Clinical Immunology - January 13, 2023 Category: Allergy & Immunology Authors: A Chousein H Duman Senol E Ece Özdoğru S Eren Akarcan T Tuncel Source Type: research
