Alanine scanning of IgE-binding to the N-terminal epitope of Ara h 2 reveal critical amino acids

IgE binding to linear peptides of the N-terminal epitope (epitope 1: DRRCQSQLERAN) of Ara h 2 correlates with sensitivity to challenge in infants with peanut allergy and may be important for tree nut and peanut cross reactivity.

Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Joshua Bernstein, Nicole Canon, Catherine Schein, Werner Braun, Surendra Negi, Marina Pozzoli, Xueni Chen, Stephen Dreskin Source Type: research