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Vaccination: Veterinary Vaccinations

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Total 406 results found since Jan 2013.

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy
Conclusion: The GMP drug product developed for treatment of fish allergy has the characteristics targeted for in FAST: i.e. hypoallergenicity with retained immunogenicity. These results have warranted first-in-man immunotherapy studies to evaluate the safety of this innovative vaccine.Int Arch Allergy Immunol 2015;166:41-51
Source: International Archives of Allergy and Immunology - February 28, 2015 Category: Allergy & Immunology Source Type: research

Neonatal vaccination with plasmid DNA encoding Cyn d 1 effectively prevents allergic responses in mice.
CONCLUSION: This study shows the prophylactic effects of DNA vaccine encoding Bermuda grass pollen allergen Cyn d 1 on specific IgE responses in neonatal mice. PMID: 24980227 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - May 1, 2014 Category: ENT & OMF Authors: Huang CF, Wu CC, Chu DM, Chang ZN, Chue FL, Peng HJ Tags: Am J Rhinol Allergy Source Type: research

Diagnosis and allergen immunotherapy treatment of polysensitised patients with respiratory allergy in Spain: an Allergists’ Consensus
Conclusion Some criteria have been established to improve diagnosis and AIT prescription in polysensitised patients.
Source: Clinical and Translational Allergy - November 7, 2014 Category: Allergy & Immunology Source Type: research

Induction of Immune Response and Protective Immunity by a Local Isolated Varicella Virus in Animal Model: A Future Candidates for Vaccine Production.
Abstract Preparation of the indigenous varicella zoster vaccine could significantly reduce the disease burden of varicella zoster virus especially in immunosuppressed children. To achieve this goal, the varicella zoster virus was isolated from an 8 years boy infected with chicken pox. The virus was cultivated in sensitive cell line and determined varicella zoster. The adaptation and attenuation of virus was carried out after several passages in MRC-5 cell culture, Primary Guinea pig embryo fibroblast cell culture and again switching in MRC-5 cell culture. The challenged of vaccine dose was found 3LogCCID50. Follow...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 31, 2018 Category: Allergy & Immunology Authors: Esna-Ashari F, Sabahi F, Ravanshad M, Mohammadi A Tags: Iran J Allergy Asthma Immunol Source Type: research

CbpM and CbpG of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged with a Serotype 19F Pneumococcus.
This study aims to determine the immunogenicity of CbpM, CbpG and CbpL proteins of Streptococcus pneumoniae in a mice model. The genes were cloned into pET21a expression vector and the recombinant proteins were produced. Mice were immunized with the purified recombinant proteins. Subsequently, the mice were challenged with S. pneumoniae ATCC 49619 (2×106 CFU) and their survival and bacterial clearances were followed 24 hours after infection. The antibody responses of the mice were determined by ELISA assay. The opsonophagocytosis assay was performed using rabbit's sera. Passive immunization was carried out using two doses...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 3, 2018 Category: Allergy & Immunology Authors: Kazemian H, Afshar D, Garcia E, Pourmand MR, Jeddi-Tehrani M, Aminharati F, Shokri F, Yazdi MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Key Steps in Vaccine Development.
CONCLUSION: In an era of increasing vaccine hesitancy the need for a better and widespread understanding of how immunization acts to counteract the continuing and changing risks from the pathogenic world is required. This demands a societal responsibility for obligate education on the benefits of vaccination, which as a medical intervention has saved more lives than any other procedure. PMID: 32044451 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Stern PL Tags: Ann Allergy Asthma Immunol Source Type: research

In Silico Design and Evaluation of Acinetobacter baumannii Outer Membrane Protein a Antigenic Peptides As Vaccine Candidate in Immunized Mice.
In this study, considering the fact that outer membrane protein A is one of the most promising vaccine candidates, we predicted T cell and B cell epitopes on this protein using sequence-based epitope prediction tools and determined whether or not mice immunized with these peptides induce an immune response. We selected consensus epitopes including five peptides in different tools with the highest score. 48 female C5BL/6 SPF injected subcutaneously with the peptides (peptide1 to peptide 5 separately) in 100 μL of the solution and sham groups received adjuvant and PBS alone on the same schedule: on day 0 (primary dose) and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 9, 2019 Category: Allergy & Immunology Authors: Mehdinejadiani K, Bandehpour M, Hashemi A, Ranjbar MM, Taheri S, Jalali SA, Mosaffa N Tags: Iran J Allergy Asthma Immunol Source Type: research

Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Mehrab Mohseni M, Amani J, Fasihi Ramandi M, Mahjoubi F, Jafaria M, Salmanian AH Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluating the Immune Response of Recombinant H1N1 Hemagglutinin with MF59 Adjuvant in Animal Model as a Novel Alternative to the Influenza Vaccine.
This study examines the potential function of formulated H1N1 hemagglutinin with MF59 adjuvant against A/PR/8/34 (H1N1). To this end, a recombinant hemagglutinin (rHA) gene of influenza A virus was designed and expressed in SF9 cell by the Baculovirus expression system. Four groups of mice were immunized by rHA in combination with MF59, Alum adjuvant, and virus split only. The immunized mice subsequently used for the humoral immune assay and the results compared with untreated mice (negative group). Besides, both treated and control mice groups were challenged with mouse-adapted influenza virus A/PR/8/34(H1N1) through the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Rashedi N, Taghizadeh M, Mohamadynejad P, Mahdavi M, Jalalirad R Tags: Iran J Allergy Asthma Immunol Source Type: research

Molecular Evolution of Hypoallergenic Hybrid Proteins for Vaccination against Grass Pollen Allergy.
Abstract More than 10% of the population in Europe and North America suffer from IgE-associated allergy to grass pollen. In this article, we describe the development of a vaccine for grass pollen allergen-specific immunotherapy based on two recombinant hypoallergenic mosaic molecules, designated P and Q, which were constructed out of elements derived from the four major timothy grass pollen allergens: Phl p 1, Phl p 2, Phl p 5, and Phl p 6. Seventeen recombinant mosaic molecules were expressed and purified in Escherichia coli using synthetic genes, characterized regarding biochemical properties, structural fold, a...
Source: Journal of Immunology - March 18, 2015 Category: Allergy & Immunology Authors: Linhart B, Focke-Tejkl M, Weber M, Narayanan M, Neubauer A, Mayrhofer H, Blatt K, Lupinek C, Valent P, Valenta R Tags: J Immunol Source Type: research

Diphteria-tetanus-pertussis vaccine reduces specific IgE, inflammation and remodelling in an animal model of mite-induced respiratory allergy.
CONCLUSIONS: The DTPw vaccine reduced serum specific IgE, nasal and pulmonary inflammation and remodelling of the lower airways. PMID: 31630941 [PubMed - as supplied by publisher]
Source: Vaccine - October 16, 2019 Category: Allergy & Immunology Authors: Aun MV, Almeida FM, Saraiva-Romanholo BM, Martins MA, Kalil J, Arantes-Costa FM, Giavina-Bianchi P Tags: Vaccine Source Type: research

Vaccination against Allergy: A Paradigm Shift?
Abstract Since the discovery that IgE antibodies mediate allergy, decades of research have unraveled complex mechanisms associated with conventional immunotherapy and the vital protagonists that shape 'immune tolerance' to allergens. Debate exists on what should constitute the dominant effector mechanism in driving rational drug designs for next-generation immunotherapies. As vaccine technology continues to advance, the development of novel vaccines in this area of continued medical need might stand on a threshold of breakthrough inspired by experiments by Dunbar on the passive vaccination of allergic animals more...
Source: Trends in Molecular Medicine - March 31, 2020 Category: Molecular Biology Authors: Bachmann MF, Mohsen MO, Kramer MF, Heath MD Tags: Trends Mol Med Source Type: research

Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Gonorrhea Vaccines: the Way Forward".
Abstract There is an urgent need for the development of an anti-gonococcal vaccine due to the increasing drug resistance found in this pathogen. The U.S. Center for Disease Control (CDC) has identified multidrug-resistant gonococci (GC) as one of 3 "urgent" hazard level threats to the U.S. POPULATION: In light of this, on June 29-30, 2015, the National Institute for Allergy and Infectious Diseases (NIAID) sponsored a workshop entitled "Gonorrhea Vaccines: the Way Forward". The goals of the workshop were to gather leaders in the field to discuss several key questions on the current status of gonorrhea vaccine ...
Source: Clinical and Vaccine Immunology - June 21, 2016 Category: Allergy & Immunology Authors: Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD Tags: Clin Vaccine Immunol Source Type: research

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy
Purpose of review Molecular forms of allergen-specific immunotherapy (AIT) are continuously emerging to improve the efficacy of the treatment, to shorten the duration of protocols and to prevent any side effects. The present review covers the recent progress in the development of AIT based on nucleic acid encoding allergens or CpG oligodeoxynucleotides (CpG-ODN). Recent findings Therapeutic vaccinations with plasmid deoxyribonucleic acid (DNA) encoding major shrimp Met e 1 or insect For t 2 allergen were effective for the treatment of food or insect bite allergy in respective animal models. DNA expressing hypoal...
Source: Current Opinion in Allergy and Clinical Immunology - November 8, 2021 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research