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Total 241 results found since Jan 2013.

Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma.
CONCLUSION: Caspase-1 inhibitors, anti-IL-18 antibodies, anti-IL-18 receptor antibodies, IL-18 binding protein, or inhibitors of genes downstream of the IL-18 signal transduction pathway may be of clinical benefit for the treatment of patients with severe asthma. PMID: 24331389 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - December 22, 2013 Category: Allergy & Immunology Authors: Oda H, Kawayama T, Imaoka H, Sakazaki Y, Kaku Y, Okamoto M, Kitasato Y, Edakuni N, Takenaka S, Yoshida M, Iwanaga T, Kato S, O'Byrne PM, Hoshino T Tags: Ann Allergy Asthma Immunol Source Type: research

History of allergic diseases and lung cancer risk.
CONCLUSION: All 3 allergic diseases examined were inversely associated with lung cancer, although the strength of the protective effect varied. History of allergic diseases seems to have a protective role in lung cancer incidence, after consideration of potential confounders, including lifetime smoking history. PMID: 24439421 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 15, 2014 Category: Allergy & Immunology Authors: El-Zein M, Parent ME, Siemiatycki J, Rousseau MC Tags: Ann Allergy Asthma Immunol Source Type: research

Flow cytometry applications in the study of immunological lung disorders.
Abstract The use of flow cytometry in the clinical laboratory has grown substantially in the past decade. Flow cytometric analysis provides a rapid qualitative and quantitative description of multiple characteristics of individual cells. For example, it is possible to detect the cell size and granularity, aspects of DNA and RNA content and the presence of cell surface and nuclear markers which are used to characterize the phenotype of single cells. Flow cytometry has been used for the immunophenotyping of a variety of specimens including whole blood, bone marrow, serous cavity fluids, (cerebrospinal fluid) CSF, ur...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 26, 2014 Category: Allergy & Immunology Authors: Mortaz E, Gudarzi H, Tabarsi P, M Adcock I, Masjedi MR, Jamaati HR, Garssen J, Velayati AA, A Redegeld F Tags: Iran J Allergy Asthma Immunol Source Type: research

The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor.
We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction. PMID: 26739412 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 16, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer.
CONCLUSIONS: IgG sensitization to indoor dust EVs appears to be a major risk for the development of asthma, COPD, and lung cancer. PMID: 26922929 [PubMed - as supplied by publisher]
Source: Allergy, Asthma and Immunology Research - March 1, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training.
Abstract The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; nicotine derived nitrosamine ketone) is one of the strongest carcinogens in tobacco which is involved in induction of lung cancer by changing the stimulation of vascular endothelial growth factor (VEGF) and annexin A2 expression. The aim of this study was to investigate the changes in resting levels of annexin A2 and VEGF in lung tissues of rats exposed NNK after 12 weeks of aerobic submaximal swimming training. For this purpose, 46 Wistar rats were randomly divided into five groups consist of training, training + NNK, NNK, saline and co...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 7, 2018 Category: Allergy & Immunology Authors: Barzegari A, Mirdar S, Ranayi M Tags: Iran J Allergy Asthma Immunol Source Type: research

In Silico Structural Prediction and Production of a Chimeric Recombinant Dickkopf-1 (DKK-1) Antigen.
Abstract Dickkopf (DKK) family of proteins are known as antagonists for the Wnt-β-catenin signaling pathway. It is suggested that the Dickkopf-1 (DKK-1) has a role in several diseases such as hepatocellular carcinomas, hepatoblastomas, Wilms' tumors, lung cancer and Myeloma bone disease. The aim of the present study was to produce a chimeric-recombinant DKK-1 protein in order to induce immune response against the antigen. The recombinant Dickkopf-1 (rDKK-1) protein was designed using bioinformatics analysis. The standard methods were used for cloning, expression and purification. The structure of recombinant prot...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Malaei F, Rasaee MJ, Latifi AM, Rahbarizadeh F Tags: Iran J Allergy Asthma Immunol Source Type: research

Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles.
CONCLUSIONS: The results of this study suggest that ELISA-based analysis of anti-bacterial EV antibodies titers can be used as a diagnostic tool for lung disease. The present findings provide insights into the pathogenesis of lung disease as well as a foundation for developing a novel diagnostic methodology that synergizes microbial EV metagenomics and immune assays. PMID: 32400132 [PubMed]
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.
CONCLUSIONS: In this population-based retrospective cohort study, the presence of physician-recognized COPD was associated with greater all-cause mortality and greater risk of mortality due to chronic lower respiratory diseases and lung cancer in patients with CS-dependent asthma. Early recognition and appropriate management of COPD can improve treatment outcomes in patients with CS-dependent asthma. PMID: 32638562 [PubMed]
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research

Objective allergy markers and risk of cancer mortality and hospitalization in a large population-based cohort
Conclusions We found no associations between objective allergy markers and cancer in the total population. However, skin test positivity and a high number of eosinophils were associated with a reduced risk to die of cancer in specific subgroups. Hence, it seems important to study specific subgroups defined by gender and smoking habits in order to identify allergy markers of predictive value for cancer mortality.
Source: Cancer Causes and Control - November 12, 2014 Category: Cancer & Oncology Source Type: research

Effects of antioxidant supplements and nutrients on patients with asthma and allergies.
Abstract Asthma and allergic diseases have become a worldwide public health concern because of their increased prevalence. Despite decades of research on risk factors, the causes of these disorders are poorly understood. They are thought to develop through complex interactions between genetic and environmental factors. Because pulmonary and systemic oxidative stress increase inflammatory responses relevant to asthma and allergy, dietary or vitamin supplementation with antioxidants (a broad and varied category) has been proposed as an approach to reducing asthma incidence or morbidity. Meta-analyses of observationa...
Source: Clinical Lung Cancer - May 1, 2014 Category: Cancer & Oncology Authors: Moreno-Macias H, Romieu I Tags: J Allergy Clin Immunol Source Type: research

GLI2 promoter hypermethylation in saliva of children with a respiratory allergy.
Conclusion: GLI2 is considered an interesting candidate DNA methylation marker for respiratory allergy. PMID: 29682088 [PubMed - in process]
Source: Clinical Lung Cancer - April 25, 2018 Category: Cancer & Oncology Authors: Langie SAS, Moisse M, Szarc Vel Szic K, Van Der Plas E, Koppen G, De Prins S, Louwies T, Nelen V, Van Camp G, Lambrechts D, Schoeters G, Vanden Berghe W, De Boever P Tags: Clin Epigenetics Source Type: research

Emerging allergies to cannabis
We report 6 clinical cases of immediate hypersensitivity related to CS.Subjects were young adults (27-41 years; 2M/4F) current or former C smokers. Symptoms were:plant food allergies due to cross-reactive lipid transfer proteins (LTP) (n= 5) (Metz-Favre C et al. Eur Ann Allergy Clin Immunol. 2011 Dec;43(6):193-5), rhinitis/asthma (n= 3), contact urticaria/eczema (n=3) and effort anaphylaxis (n=1). All had positive CS sIgE (median 8.05 (4.35-21.9) kU/L) (Ebo D et al. Int Arch Allergy Immunol. 2013;161:220-8). In 1 case, SPT with crude CS was made and strongly positive. All subjects were atopic.Up to now, C consumption has b...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Doyen, V., Debaugnies, F., Ledent, C., Corazza, F., Michel, O., Mairesse, M. Tags: 5.3 Allergy and Immunology Source Type: research

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies.
Abstract Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of a...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Cui Y, Hill AW Tags: Clin Rev Allergy Immunol Source Type: research