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Viruses, Vol. 15, Pages 1832: Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome
This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to CZS. Gene expression quantified by qPCR in whole blood samples showed an increase in IFNγ and IL-13 transcripts in children affected with microcephaly compared to the control group. The microcephaly group exhibited significantly decreased CCL2 and CXCL8 levels in serum, quantified by CBA assay. An allergic profile questionnaire revealed a high prevalence of allergies in the microcephaly group. In accordance, elevated serum IgE level measured by the Proquantum Immunoassay was observed in children affec...
Source: Viruses - August 29, 2023 Category: Virology Authors: Wallace Pitanga Bezerra Amanda Costa Ayres Salmeron Anna Cl áudia Calvielli Castelo Branco Ingryd Camara Morais Val éria Soraya de Farias Sales Paula Renata Lima Machado Janeusa Trindade Souto Jos élio Maria Galvão de Araújo Paulo Marcos da Matta Gue Tags: Article Source Type: research
A qualitative investigation into vaccine hesitancy and confidence among people managing allergy
Vaccine hesitancy is multifactorial, and among atopic individuals, is exacerbated by documented, but rare, cases of allergic reactions to coronavirus disease 2019 (COVID-19) vaccines.1 –3 Furthermore, conflicting information regarding the safety of COVID-19 vaccines may have caused confusion among individuals with a history of severe allergies. We performed semistructured qualitative interviews to better understand how some adults and families managing allergy perceive vaccine m essaging and what influences their decisions to be vaccinated.
Source: Annals of Allergy, Asthma and Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Ayel Luis R. Batac, Kaitlyn A. Merrill, Michael A. Golding, Elissa M. Abrams, Philippe B égin, Moshe Ben-Shoshan, Erika Ladouceur, Leslie E. Roos, Vladan Protudjer, Jennifer L.P. Protudjer Tags: Letters Source Type: research
A qualitative investigation into vaccine hesitancy and confidence amongst people managing allergy
Vaccine hesitancy has a multifactorial etiology, and, among atopic individuals, is exacerbated by documented, but rare, cases of allergic reactions to COVID-19 vaccines.1 –3 Furthermore, conflicting information regarding the safety of COVID-19 vaccines may have caused confusion among individuals with history of severe allergies. We performed semi-structured qualitative interviews to better understand how some adults and families managing allergy perceive vaccine me ssaging, and what influences their decisions to be vaccinated.
Source: Annals of Allergy, Asthma and Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Ayel Luis R. Batac, Kaitlyn A. Merrill, Michael A. Golding, Elissa M. Abrams, Philippe B égin, Moshe Ben-Shoshan, Erika Ladouceur, Leslie E. Roos, Vladan Protudjer, Jennifer L.P. Protudjer Tags: Letters Source Type: research
Impact of SARS-CoV-2 mRNA vaccine on arthritis condition in rheumatoid arthritis
ConclusionRA patients had more frequent and longer-lasting arthralgia after vaccination than healthy subjects, and one-third of patients with post-vaccination arthralgia required additional DMARDs. Although the SARS-CoV-2 mRNA vaccine was administered safely in most RA patients, in some patients RA symptoms may worsen after vaccination.
Source: Frontiers in Immunology - August 25, 2023 Category: Allergy & Immunology Source Type: research
We Can Prevent Overdose Deaths If We Change How We Think About Them
I’ve been living in recovery from opioid use disorder for eight and a half years, and this might be a weird thing to say about addiction, but I feel lucky—like I dodged a bullet. I was addicted to opioids in Florida throughout the early 2000s, during the heyday of pill mills that flooded the streets with powerful pharmaceuticals like OxyContin. I say I’m lucky because this was just before the drug supply turned into a toxic sludge of potent fentanyl analogues, mysterious tranquilizers, and deadly counterfeit pills. Sometimes I wonder what it would be like if I were using today. The chances of my survival ...
Source: TIME: Health - August 15, 2023 Category: Consumer Health News Authors: Ryan Hampton Tags: Uncategorized freelance Source Type: news
Doctors have long considered the thymus expendable. But could removing it be fatal?
The thymus, a butterfly-shaped organ that sits between our collarbones, has never seemed like a particularly useful appendage—at least in adults. During early childhood, it provides a place for T cells (the T stands for thymus) to mature into immune cells that attack invaders. But during adolescence the organ begins to shrink and mostly stops producing these cells. By adulthood, it’s assumed to be so useless that cardiac surgeons will occasionally remove it just to get easier access to the heart.
But researchers have recently started to question that assumption, and a study published today in
The New England Jo...
Source: ScienceNOW - August 2, 2023 Category: Science Source Type: news
HIV researcher will head NIH ’s infectious disease institute
The infectious disease institute at the U.S. National Institutes of Health (NIH) will soon have its first new chief in nearly 4 decades. Jeanne Marrazzo, an expert on sexually transmitted infections, will become director of the National Institute of Allergy and Infectious Diseases (NIAID) in the fall. She will succeed Anthony Fauci, who
stepped down
in December 2022 after 38 years at NIAID’s helm.
Marrazzo, 61, currently directs the Division of Infectious Diseases at the University of Alabama at Birmingham (UAB). A physician and epidemiologist, she has expertise in HIV prevention, vaginal infections, horm...
Source: ScienceNOW - August 2, 2023 Category: Science Source Type: news
University of Alabama HIV researcher will head NIH ’s infectious disease institute
The infectious disease institute at the U.S. National Institutes of Health (NIH) will soon have its first new chief in nearly 4 decades. Jeanne Marrazzo, an expert on sexually transmitted infections, will become director of the National Institute of Allergy and Infectious Diseases (NIAID) in the fall. She will succeed Anthony Fauci, who
stepped down
in December 2022 after 38 years at NIAID’s helm.
Marrazzo, 61, currently directs the Division of Infectious Diseases at the University of Alabama at Birmingham (UAB). A physician and epidemiologist, she has expertise in HIV prevention, vaginal infections, horm...
Source: ScienceNOW - August 2, 2023 Category: Science Source Type: news
Safety of Inactivated SARS-CoV-2 Vaccines Among Adults with Experience of Allergies to Food or Medicines
Source: International Journal of General Medicine - July 21, 2023 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
The Conspirituality of Robert F. Kennedy Jr.
This article has been adapted from Chapter 23 of Conspirituality: How New Age Conspiracy Theories Became a Health Threat by Derek Beres, Matthew Remski, and Julian Walker. Copyright © 2023. Available from PublicAffairs, an imprint of Hachette Book Group, Inc.
Source: TIME: Health - July 5, 2023 Category: Consumer Health News Authors: Derek Beres, Matthew Remski, and Julian Walker Tags: Uncategorized freelance politics Source Type: news
How molecular diagnostics help us to correctly identify pet allergies
SummarySimultaneous sensitization to two or more animal species is common and represents a regular diagnostic problem during conventional extract-based allergy diagnosis. The use of single allergen molecules reveals the underlying cause of polysensitization and enables the distinction between primary sensitization and cross-reaction as a prerequisite for the selection of appropriate im munotherapy vaccines. Individual sensitization patterns can be valuable predictors of clinical relevance, symptom severity and asthma risk, and in part reflect current or past animal exposure. The concept of “marker allergens” is chal...
Source: Allergo Journal International - July 5, 2023 Category: Allergy & Immunology Source Type: research
Adverse events following immunisation (AEFI) of COVISHIELD vaccination among healthcare workers in Ghana
Conclusion
The results of our study indicate a high incidence of non-serious AEFI and the rare occurrence of serious AEFI after COVISHIELD vaccination in healthcare workers. The rate of AEFI was higher after the first dose than after the second dose. Sex, age, previous SARS-CoV-2 infection, allergies and comorbidity were not significantly associated with the onset and duration of AEFI.
Source: BMJ Open - June 28, 2023 Category: General Medicine Authors: Marfoh, K., Samba, A., Okyere, E., Acheampong, F., Owusu, E., Darko, D. N. A., Zakariah, J., Mensa, H., Aidoo, E., Mohammed, Y. Tags: Open access, Immunology (including allergy), COVID-19 Source Type: research
Infants immunisations, their timing and the risk of allergic diseases (INITIAL): an observational prospective cohort study protocol
Introduction
Vaccinations are considered to have a large impact on disease control, hence a multitude of vaccines in infancy is recommended. Retrospective studies suggest a possible relation between timing, kind or number of vaccines given in the first year of life and the subsequent incidence of allergic diseases. It must be clarified whether a causal relationship exists to ensure safety and reduce vaccine hesitancy.
Methods and analysis
Due to the high recommendation rate of vaccines, a long-term randomised controlled trial is not considered as ethically acceptable. Therefore, this study aims to observe prospectively th...
Source: BMJ Open - June 23, 2023 Category: General Medicine Authors: Wrenger, J., Martin, D. D., Jenetzky, E. Tags: Open access, Public health Source Type: research
Allergen ‐specific immunotherapy by recombinant Der P1 allergen‐derived peptide‐based vaccine in an allergic mouse model
ConclusionThe use of present available recombinant proteins is considered a viable, cost-effective, and long-term option for providing effective HDM allergy immunotherapy vaccines without side effects.
Source: Immunity, Inflammation and Disease - June 9, 2023 Category: Allergy & Immunology Authors: Soheila Asoudeh Moghanloo,
Mohsen Forouzanfar,
Mojtaba Jafarinia,
Mohammad R. Fazlollahi,
Gholam Ali Kardar Tags: ORIGINAL ARTICLE Source Type: research
Over 90% of Childhood BCG Vaccine-Induced Keloids in Japan Occur in Women
ConclusionTo our knowledge, this is the largest report in the literature on childhood-onset keloids. There was overall female predominance in childhood-onset keloids, and even more significant female predominance in BCG-induced keloids.
Source: Dermatology and Therapy - May 1, 2023 Category: Dermatology Source Type: research
