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Total 61 results found since Jan 2013.

Traditional skin tests used to predict allergies to antibiotics are useless say Montreal researchers
(McGill University Health Centre) Skin tests traditionally used to predict allergies to amoxicillin, one of the most commonly prescribed antibiotics in children, are ineffective according to a new study led by a team from the McGill University Health Centre in Montreal. The findings, published in the journal JAMA Pediatrics this week, determined that oral provocation or challenge test, with appropriate follow up, was a more efficient and safer screening method for diagnosing non-life threatening reactions to amoxicillin in children.
Source: EurekAlert! - Infectious and Emerging Diseases - April 7, 2016 Category: Infectious Diseases Source Type: news

Traditional skin tests used to predict allergies to antibiotics are useless. say researchers
Skin tests traditionally used to predict allergies to amoxicillin, one of the most commonly prescribed antibiotics in children, are ineffective according to a new study. The findings determined that oral provocation or challenge test, with appropriate follow up, was a more efficient and safer screening method for diagnosing non-life threatening reactions to amoxicillin in children.
Source: ScienceDaily Headlines - April 8, 2016 Category: Science Source Type: news

Traditional skin tests used to predict allergies to antibiotics are useless, say researchers
Skin tests traditionally used to predict allergies to amoxicillin, one of the most commonly prescribed antibiotics in children, are ineffective according to a new study. The findings determined that oral provocation or challenge test, with appropriate follow up, was a more efficient and safer screening method for diagnosing non-life threatening reactions to amoxicillin in children.
Source: ScienceDaily Headlines - April 8, 2016 Category: Science Source Type: news

Skin tests for antibiotic allergies branded ‘useless’
Skin tests traditionally used to predict allergies to amoxicillin, one of the most commonly prescribed antibiotics in children, are ineffective, according to Canadian researchers.
Source: Nursing Times - April 12, 2016 Category: Nursing Source Type: news

Penicillin skin testing in hospitalized patients with β-lactam allergies: Effect on antibiotic selection and cost.
CONCLUSION: After the implementation of a PST protocol, we observed a decrease in non-BLA use in patients with previously documented β-lactam allergy. PST is a safe and cost-effective procedure to serve as a negative predictor test for penicillin hypersensitivity mediated by IgE. PMID: 27211057 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 18, 2016 Category: Allergy & Immunology Authors: King EA, Challa S, Curtin P, Bielory L Tags: Ann Allergy Asthma Immunol Source Type: research

Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector
Conclusions The study shows that dispensing of antimicrobial drugs without prescription by pharmacies in the private sector in India within an urban setting was unacceptably high, thus placing a high burden on healthcare expenditure. There is an urgent need to institute measures to curb unnecessary antimicrobial usage in India, address market incentives and involve pharmacists as partners for creating awareness among communities.
Source: Antimicrobial Resistance and Infection Control - December 11, 2015 Category: Infectious Diseases Source Type: research

De ‐labelling self‐reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing
ConclusionSelected patients in the ED who self‐report an allergy to penicillin can be safely tested there for penicillin allergy, using skin tests and oral drug provocation testing. This testing allows a significant de‐labelling of penicillin allergy, with the majority of these patients able to tolerate penicillin without incident.
Source: Emergency Medicine Australasia - April 5, 2017 Category: Emergency Medicine Authors: Joseph Marwood, Gonzalo Aguirrebarrena, Stephen Kerr, Susan A Welch, Janet Rimmer Tags: Original Research Source Type: research

Impact of antibiotic prophylaxis on the incidence, nature, magnitude, and duration of bacteremia associated with dental procedures: A systematic review.
Authors: Lafaurie GI, Noriega LA, Torres CC, Castillo Y, Moscoso SB, Mosquera S, Díaz-Báez D, Chambrone L Abstract BACKGROUND: Antibiotic prophylaxis (AP) is used routinely in high-risk groups of patients to reduce bacteremia and the risk of developing infective endocarditis (IE). In this systematic review, the authors evaluated the efficacy of AP on the incidence, nature, magnitude, and duration of post-dental procedure bacteremia. METHODS: The authors conducted a systematic search of the literature using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials up to and including May 2019. Th...
Source: Journal of the American Dental Association - September 30, 2019 Category: Dentistry Tags: J Am Dent Assoc Source Type: research

Contribution of Penicillin Allergy Labels to Second-Line Broad-Spectrum Antibiotic Prescribing for Pediatric Respiratory Tract Infections
ConclusionIn a large population of pediatric outpatient encounters for acute respiratory tract infections, patients labeled with a penicillin allergy accounted for nearly half of second-line antibiotics, which are often broader spectrum. Efforts to de-label children with penicillin allergies have the potential to reduce broader-spectrum antibiotic use.
Source: Infectious Diseases and Therapy - July 12, 2020 Category: Infectious Diseases Source Type: research

Amoxicillin oral provocation challenge in a primary care clinic: a descriptive analysis
CMAJ Open. 2021 Apr 16;9(2):E394-E399. doi: 10.9778/cmajo.20200077. Print 2021 Apr-Jun.ABSTRACTBACKGROUND: Penicillin is the most frequently reported drug allergen; however, most of these allergies are not true allergies and do not justify the prescription of alternative, less effective and more expensive antibiotic drugs. We aimed to show that patients at low risk of amoxicillin allergy can safely and efficiently undergo oral provocation challenge (OPC) by their primary care physician.METHODS: In this descriptive analysis, we conducted a retrospective chart review of all primary care patients who had undergone OPC from No...
Source: cmaj - April 17, 2021 Category: General Medicine Authors: Derek Paul Gateman Jessie Erin Rumble Jennifer L P Protudjer Harold Kim Source Type: research

Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule
CONCLUSION: PEN-FAST has been validated to identify low-risk penicillin allergies in our European cohort of patients mainly reporting anaphylaxis. This is the first reported external validation of a penicillin allergy clinical decision rule internationally.AUTHOR CONTRIBUTIONS: Concept and design: Piotin, de Blay, Metz-Favre. Acquisition, analysis, or interpretation of data: All authors.Drafting of the manuscript: Piotin, de Blay, Metz-Favre. Critical revision of the manuscript for important intellectual content: All authors.CONFLICTS OF INTEREST: All authors except Frédéric de Blay have no conflict of interest. Frédér...
Source: Annals of Allergy, Asthma and Immunology - July 16, 2021 Category: Allergy & Immunology Authors: Anays Piotin Julien GodetPhD Jason A Trubiano Manon Grandbastien Lydie Guenard Fr édéric de Blay Carine Metz Favre Source Type: research

Penicillin and Beta-Lactam Allergy: Epidemiology and Diagnosis
Abstract Penicillin is the most common beta-lactam antibiotic allergy and the most common drug class allergy, reported in about 8 % of individuals using health care in the USA. Only about 1 % of individuals using health care in the USA have a cephalosporin allergy noted in their medical record, and other specific non-penicillin, non-cephalosporin beta-lactam allergies are even rarer. Most reported penicillin allergy is not associated with clinically significant IgE-mediated reactions after penicillin rechallenge. Un-verified penicillin allergy is a significant and growing public health problem. Clinically signi...
Source: Current Allergy and Asthma Reports - September 13, 2014 Category: Allergy & Immunology Source Type: research