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Tai Chi-induced exosomal LRP1 is associated with memory and hippocampus plasticity in aMCI patients
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder, characterized by aggregation and deposition of amyloid- β (Aβ) peptides in brain1. As an intermediate phase from normal aging to prodromal AD, amnestic mild cognitive impairment (aMCI) is widely recognized as a pivotal stage for early intervention to avoid further cognitive deterioration2,3. It's a high-risk type of MCI that progresses to AD2, typicall y characterized by episodic memory impairment4. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 25, 2024 Category: Geriatrics Authors: Miaoran Lin, Weilin Liu, Chuyi Ma, Jiahui Gao, Li huang, Jingfang Zhu, Shengxiang Liang, Youze He, Jiao Liu, Jing Tao, Zhizhen Liu, Jia Huang, Zhifu Wang, Lidian Chen Tags: Regular Research Article Source Type: research

Commentary on "Study Partner Report of Apathy in Older Adults is Associated With AD Biomarkers: Findings From the Harvard Aging Brain Study"
Am J Geriatr Psychiatry. 2024 Apr 4:S1064-7481(24)00298-7. doi: 10.1016/j.jagp.2024.03.017. Online ahead of print.NO ABSTRACTPMID:38658231 | DOI:10.1016/j.jagp.2024.03.017 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 24, 2024 Category: Psychiatry Authors: Siddharth Khasnavis Ryan S O'Dell Christopher H van Dyck Adam P Mecca Source Type: research

Adherence to Online Interventions for Family Caregivers of People with Dementia: A Meta-analysis and Systematic Review
With the rapid increase in the proportion of people with dementia, the number of family caregivers providing unpaid care and support is also growing worldwide. Family caregivers are an essential pillars of dementia management efforts, as they reduce the economic cost of care and play an important role in supporting the quality of life in people with dementia [2]. While caregiving can provide a sense of fulfilment, the burden of caregiving can also cause significant psychological challenges [3]. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 24, 2024 Category: Geriatrics Authors: Golnaz L. Atefi, Wei Qi Koh, Gianna Kohl, Mohammad Seydavi, Joshua K. Swift, Mehdi Akbari, Marjolein E. deVugt Tags: Clinical Review Article Source Type: research

Risk of sleep problems in middle-aged and older adults experiencing bodily pains: Serial multiple mediation estimates of emotion distress and activity limitations
Sleep is essential for cognitive and physiological adjustment and well-being across the lifespan. However, the quantity and quality of sleep reduce significantly with increasing age, chiefly due, in part, to circadian rhythm fatigue [1,2]. Indeed, less than one-half of older adults meet the clinical recommendations for 7-9 hours of sleep [3]. Those in middle ages and older cohorts, particularly in low- and middle-income countries (LMICs), experience worse sleep problems (SP) due to environmental and age-related changes in melatonin secretion, sleep-wake homeostasis, and circadian rhythm [4]. (Source: The American Journal o...
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Razak M. Gyasi, Emelia Aikins, Gift Dumedah, Nelson Gyasi-Boadu, Prince Boakye Frimpong, Mary Sefa Boampong, Daniel Buor, Simon Mariwah, Francis Naab, David R. Phillips Tags: Regular Research Article Source Type: research

Association of regular opioid use with incident dementia and neuroimaging markers of brain health in chronic pain patients: analysis of UK Biobank
Opioid analgesics have proven essential for relieving acute pain, cancer-related pain, and in palliative care inverventions.1 Over the past two decades, there has been a significant increase in the prescription of opioids for various chronic non-cancer pain (CNCP) conditions.2,3 This has become worrisome, especially given the limited evidence regarding the efficacy of opioids over non-opioid analgesics for CNCP4 and the potential cognitive detriments associated with their use. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Yaqing Gao, Binbin Su, Lei Ding, Danial Qureshi, Shenda Hong, Jie Wei, Chao Zeng, Guanghua Lei, Junqing Xie Tags: Regular Research Article Source Type: research

The effects of simultaneous aerobic exercise and video game training on executive functions and brain connectivity in older adults
Executive functions (EFs) encompass a set of higher-level cognitive control abilities, including inhibition, cognitive flexibility, and working memory.1 These functions are crucial for facilitating action control and adaptive responses to dynamic environmental changes.2 Consensus suggests that executive functions (EFs) decline noticeably with age, often associated with dysfunctions in the prefrontal cortex (PFC) regions and their associated networks, including the bilateral frontoparietal networks (FPN). (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 20, 2024 Category: Geriatrics Authors: Wenjun Gui, Xiaoyu Cui, Jingwen Miao, Xinyi Zhu, Juan Li Tags: Regular Research Article Source Type: research

Meeting the WHO Physical Activity Guidelines is Associated With Lower Odds of Depression in Older Adults: Potential Psychosomatic Mechanisms
CONCLUSIONS: PA was negatively associated with depression among older adults in Ghana, and psychosocial and physical factors partially explained the association. The promotion of PA in old age may aid in the prevention of depression, especially in men and those aged 50-64 years. Longitudinal data may confirm our findings.PMID:38641509 | DOI:10.1016/j.jagp.2024.04.001 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 19, 2024 Category: Psychiatry Authors: Razak M Gyasi Nicholas Quansah Paul Antwi Boateng Eric Akomeah Abdul-Fatawu Yakubu Patience Aku Ahiabli Emelia Aikins Obed Jones Owusu-Sarpong Yunus Dumbe Michael Nimoh David R Phillips Andr é Hajek Source Type: research

The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders
CONCLUSIONS: We did not find consistent evidence for the role of leptin, its receptor, and total and hmw adiponectin in POD and POCD risk. Future research should be used to support or refute our findings and to fully characterize any differences in the associations of these hormones with POD/POCD between obese and nonobese individuals.PMID:38637191 | DOI:10.1016/j.jagp.2024.03.015 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 18, 2024 Category: Psychiatry Authors: Insa Feinkohl J ürgen Janke Arjen J C Slooter Georg Winterer Claudia Spies Tobias Pischon Source Type: research

Opportunity Costs for Families Providing Home and Community Base Dementia Care. Can We Have a Real Discussion about Policy?
Jang and Chen's report, “National Estimates of Incremental Absenteeism Costs Associated with Adult Children of Parents with Alzheimer's Disease and Related Dementia (ADRD),” provides important estimates for an understudied category of “opportunity costs” for work absenteeism among children providing home and commun ity based care (HCBC) for an ADRD parent verses those caring for a non-ADRD parent. (1) Using an elegantly designed econometric model and merged data from the 2015 through 2021 Medical Expenditure Panel Survey (MEPS), the investigators described sociodemographic characteristics of each HCBC caregive r gr...
Source: The American Journal of Geriatric Psychiatry - April 18, 2024 Category: Geriatrics Authors: Christopher C. Colenda Tags: Editorial Source Type: research

Even the Simplest Questions May Cause Harm: How One Woman With Profound Dementia Taught me About the Stress of a Multiple Questions
Am J Geriatr Psychiatry. 2024 Apr 5:S1064-7481(24)00296-3. doi: 10.1016/j.jagp.2024.03.016. Online ahead of print.NO ABSTRACTPMID:38616472 | DOI:10.1016/j.jagp.2024.03.016 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 15, 2024 Category: Psychiatry Authors: Maureen C Nash Source Type: research

Redefining Success: A Champion's Journey Beyond the Finish Line
Am J Geriatr Psychiatry. 2024 Apr 4:S1064-7481(24)00300-2. doi: 10.1016/j.jagp.2024.04.002. Online ahead of print.NO ABSTRACTPMID:38614874 | DOI:10.1016/j.jagp.2024.04.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 13, 2024 Category: Psychiatry Authors: Charles Clark Source Type: research