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Therapy: Stem Cell Therapy
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Total 54671 results found since Jan 2013.
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Gelatin-based 3D biomimetic scaffolds platform potentiates culture of cancer stem cells in esophageal squamous cell carcinoma
Biomaterials. 2023 Sep 11;302:122323. doi: 10.1016/j.biomaterials.2023.122323. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are crucial for tumorigenesis, metastasis, and therapy resistance in esophageal squamous cell carcinoma (ESCC). To further elucidate the mechanism underlying characteristics of CSCs and develop CSCs-targeted therapy, an efficient culture system that could expand and maintain CSCs is needed. CSCs reside in a complex tumor microenvironment, and three-dimensional (3D) culture systems of biomimetic scaffolds are expected to better support the growth of CSCs by recapitulating the biophysical prop...
Source: Biomaterials - September 17, 2023 Category: Materials Science Authors: Yenan Wu Haiwei Liang Aiping Luo Yong Li Zhiqiang Liu Xin Li Wenxin Li Kaini Liang Junyang Li Zhihua Liu Yanan Du Source Type: research
Growth hormone receptor gene disruption
Vitam Horm. 2023;123:109-149. doi: 10.1016/bs.vh.2022.12.004. Epub 2023 Aug 24.ABSTRACTMuch of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal GHR disruption. To date, 37 distinct GHR knockout mouse lines have been created. Targeted tissues include fat, liver, muscle, heart, bone, brain, macrophage, intestine, hematopoietic stem cells, pancreatic β cells, and inducible multi-tissue "global" disruption at various ages. In this chapter, a summ...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Edward O List Silvana Duran-Ortiz Prateek Kulkarni Emily Davis Patricia Mora-Criollo Darlene E Berryman John J Kopchick Source Type: research
Gelatin-based 3D biomimetic scaffolds platform potentiates culture of cancer stem cells in esophageal squamous cell carcinoma
Biomaterials. 2023 Sep 11;302:122323. doi: 10.1016/j.biomaterials.2023.122323. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are crucial for tumorigenesis, metastasis, and therapy resistance in esophageal squamous cell carcinoma (ESCC). To further elucidate the mechanism underlying characteristics of CSCs and develop CSCs-targeted therapy, an efficient culture system that could expand and maintain CSCs is needed. CSCs reside in a complex tumor microenvironment, and three-dimensional (3D) culture systems of biomimetic scaffolds are expected to better support the growth of CSCs by recapitulating the biophysical prop...
Source: Biomaterials - September 17, 2023 Category: Materials Science Authors: Yenan Wu Haiwei Liang Aiping Luo Yong Li Zhiqiang Liu Xin Li Wenxin Li Kaini Liang Junyang Li Zhihua Liu Yanan Du Source Type: research
Growth hormone receptor gene disruption
Vitam Horm. 2023;123:109-149. doi: 10.1016/bs.vh.2022.12.004. Epub 2023 Aug 24.ABSTRACTMuch of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal GHR disruption. To date, 37 distinct GHR knockout mouse lines have been created. Targeted tissues include fat, liver, muscle, heart, bone, brain, macrophage, intestine, hematopoietic stem cells, pancreatic β cells, and inducible multi-tissue "global" disruption at various ages. In this chapter, a summ...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Edward O List Silvana Duran-Ortiz Prateek Kulkarni Emily Davis Patricia Mora-Criollo Darlene E Berryman John J Kopchick Source Type: research
Enhancing differentiation of menstrual blood-derived stem cells into female germ cells using a bilayer amniotic membrane and nano-fibrous fibroin scaffold
This study aims to investigate the influence of a bilayer amniochorionic membrane/nanofibrous fibroin scaffold on the differentiation of human menstrual blood mesenchymal stromal/stem cells (MenSCs) into female germ cells. MenSCs were isolated and assigned to four culture groups: (i) MenSCs co-cultured with granulosa cells (GCs) using the scaffold (3D-T group), (ii) MenSCs using the scaffold alone (3D-C group), (iii) MenSCs co-cultured only with GCs (2D-T group), and (iv) MenSCs without co-culture or scaffold (2D-C group). Both MenSCs and GCs were independently cultured for two weeks before co-culturing was initiated. Flow...
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Safoura Izanlou Alireza Afshar Afshin Zare Kulyash R Zhilisbayeva Shabnam Bakhshalizadeh Zahra Safaei Soheila Sehat-Bakhsh Sajed Khaledi Hamid-Reza Asgari Somaieh Kazemnejad Mansoureh Ajami Monireh Ajami Masoumeh Dehghan Tarzjani Vahid Najafzadeh Mohammad Source Type: research
Exosomes derived from human umbilical cord mesenchymal stem cells loaded with RVG-Lamp2b and Netrin-1 promotes Schwann cell invasion and migration
CONCLUSION: HucMSC-derived exosomes loaded with RVG-Lamp2b and Netrin-1 promote proliferation, migration, and invasion of Schwann cells.PMID:37716176 | DOI:10.1016/j.tice.2023.102219
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Jie He Zhongju Du Hua Zhang Bo Wang Jurong Xia Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lymphoma and Myeloma - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Proanthocyanidin enhances the endogenous regeneration of alveolar bone by elevating the autophagy of PDLSCs
CONCLUSION: PA may activate autophagy by inhibiting PI3K/Akt/mTOR signaling pathway to promote the osteogenesis of PDLSCs and enhance endogenous alveolar bone regeneration.PMID:37715945 | DOI:10.1111/jre.13186
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Zhuo Liu Qilin Li Xiangyao Wang Yaxin Wu Zhixing Zhang Jing Mao Shiqiang Gong Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
The repair and regeneration mechanism of platelet-rich fibrin-promoting tissue after alveolar bone defect through the notch pathway
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):85-90. doi: 10.14715/cmb/2023.69.7.14.ABSTRACTThis work investigated the effects of platelet-rich fibrin (PRF) combined with bone mesenchymal stem cells (BMSCs) on the repair of alveolar bone defect (ABD) and the related mechanism of the Notch1/Wnt3a signaling pathway. 28 healthy male New Zealand white rabbits were selected to prepare the BMSCs and PRF. Rabbits were rolled into a combination group (implanted with PRF + BMSCs for treatment), a PRF group (treated with PRF) a BMSC group (BMSCs for treatment), and a control group (Ctrl group, no material implantation), with 7 r...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tao Li Hui Long Wei Niu Bo Feng Source Type: research
Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):84-88. doi: 10.14715/cmb/2023.69.8.13.ABSTRACTTo investigate the inhibitory mechanism of the KIF3A gene on nasopharyngeal carcinoma (NPC) tumor stem cells. Set up a blank control group (BCG), NPC group, and KIF3A silence (si-KIF3A) group. The BCG cells were nasopharyngeal normal epithelial cell line NP69, without any treatment, and were cultured routinely; The NPC group cells are human NPC cell line CNE2 cells, which are not subjected to any treatment and are cultured routinely; si-KIF3A group cells were cultured in the offspring of human NPC cell line CNE2 infected with Le...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Rongrong Liu Te Li Weitao Zhang Source Type: research
