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Nutrition: Vitamins

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Vitamin D: determinants of status, indications for testing and knowledge in a convenience sample of Irish adults
Br J Nutr. 2023 Oct 14;130(7):1144-1154. doi: 10.1017/S0007114523000168. Epub 2023 Feb 9.ABSTRACTVitamin D deficiency is common in Irish adults, though there is limited research on its determinants, knowledge of vitamin D or indications for testing. We aimed to explore the determinants of vitamin D status in adults and examine knowledge and reasons for testing. The study population comprised adults who had serum 25-hydroxyvitamin D tested by general practitioners request at a Dublin Hospital in 2020. Questionnaires detailing dietary intake, sun exposure, ethnicity, biophysical factors and vitamin D knowledge were sent to a...
Source: The British Journal of Nutrition - September 7, 2023 Category: Nutrition Authors: Helena Scully Eamon J Laird Martin Healy Vivion Crowley James Bernard Walsh Kevin McCarroll Source Type: research

Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation
Eur J Med Chem. 2023 Aug 28;260:115766. doi: 10.1016/j.ejmech.2023.115766. Online ahead of print.ABSTRACTA series of novel benzofuran-based compounds 7a-s were designed, synthesized, and investigated in vitro as acetylcholinesterase inhibitors (AChEIs). Compounds 7c and 7e displayed promising inhibitory activity with IC50 values of 0.058 and 0.086 μM in comparison to donepezil with an IC50 value of 0.049 μM. The new molecules' antioxidant evaluation revealed that 7c, 7e, 7j, 7n, and 7q produced the strongest DPPH scavenging activity when compared to vitamin C. As it was the most promising AChEI, compound 7c was selected ...
Source: European Journal of Medicinal Chemistry - September 7, 2023 Category: Chemistry Authors: Somaia S Abd El-Karim Manal M Anwar Nesreen S Ahmed Yasmin M Syam Samia A Elseginy Hanan F Aly Eman A Younis Wagdy K B Khalil Kawkab A Ahmed Faten F Mohammed Maha Rizk Source Type: research

Correlation of CYP2R1 gene promoter methylation with circulating vitamin D levels among healthy adults
CONCLUSIONS: This study found no significant correlation between levels of CYP2R1 methylation and circulating 25(OH)D deficiency. Further studies on the Indian population having a larger sample size including entire vitamin D tool genes, among different ethnic groups may be conducted to elucidate molecular etiology of circulating 25(OH)D deficiency. The high prevalence of normal serum calcium and phosphate levels among vitamin D deficient subjects in this study coupled with the strikingly high prevalence of the deficiency at the national level, may suggest the need to revise the cut-off criteria for vitamin D deficiency in...
Source: The Indian Journal of Medical Research - September 7, 2023 Category: Biomedical Science Authors: Ashvin Varadharajan M K Sibin S V Athira Arijit Kumar Ghosh Pratibha Misra Source Type: research

Effects of preharvest chitosan-Myrtus communis essential oil composite and postharvest nanocellulose on quality of strawberry
The objective of this study was to investigate the effects of preharvest chitosan-Myrtus communis essential oil composite (1.5 and 3.0 %) and postharvest nanocellulose (0.3 and 0.6 %) on the quality of strawberries. The gas chromatography-mass spectrometry (GC/MS) analysis led to identification of 32 compounds in the Myrtus communis essential oil. The study showed that using CHS-ES composite coating for foliar application could increase the lifespan of the fruit by up to 24 days. This is because it increases the levels of components, such as phenol content (TPC) total flavonoids content (TFC) vitamin C, firmness and SSC. I...
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Abdollah Ehtesham Nia Elham Malekzadeh Shirin Taghipour Aliasghar Tatari Zeinab Ghasemi Arshad Source Type: research

Antiglycation, antifibrillation and antioxidative effects of para coumaric acid and vitamin D; an in-vitro and in-silico comparative-cum-synergistic approach
Biochim Biophys Acta Gen Subj. 2023 Sep 5:130455. doi: 10.1016/j.bbagen.2023.130455. Online ahead of print.ABSTRACTDiabetes Mellitus is a metabolic disorder that results in impaired utilization of carbohydrates, lipids, and proteins. Severe hyperglycemia is its principal clinical symptom. Human serum albumin (HSA) is used as a model protein since it is viewed as a sign of glycaemic management because it is more likely to get glycated in diabetic people than other proteins. Para-coumaric acid (pCA), a phenolic acid, and Vitamin D (vit-D) are used as protective agents. In the present work, we deduce a synergistic-cum-compara...
Source: Biochimica et Biophysica Acta - September 7, 2023 Category: Biochemistry Authors: Rizwan Khan Imrana Naseem Source Type: research

Correlation of CYP2R1 gene promoter methylation with circulating vitamin D levels among healthy adults
CONCLUSIONS: This study found no significant correlation between levels of CYP2R1 methylation and circulating 25(OH)D deficiency. Further studies on the Indian population having a larger sample size including entire vitamin D tool genes, among different ethnic groups may be conducted to elucidate molecular etiology of circulating 25(OH)D deficiency. The high prevalence of normal serum calcium and phosphate levels among vitamin D deficient subjects in this study coupled with the strikingly high prevalence of the deficiency at the national level, may suggest the need to revise the cut-off criteria for vitamin D deficiency in...
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Ashvin Varadharajan M K Sibin S V Athira Arijit Kumar Ghosh Pratibha Misra Source Type: research

Vitamin D Supplements in Sports: A Long Run for a Short Jump
Curr Sports Med Rep. 2023 Sep 1;22(9):297-298. doi: 10.1249/JSR.0000000000001101.NO ABSTRACTPMID:37678345 | DOI:10.1249/JSR.0000000000001101
Source: Current Sports Medicine Reports - September 7, 2023 Category: Sports Medicine Authors: E Randy Eichner Source Type: research

Correlation of CYP2R1 gene promoter methylation with circulating vitamin D levels among healthy adults
CONCLUSIONS: This study found no significant correlation between levels of CYP2R1 methylation and circulating 25(OH)D deficiency. Further studies on the Indian population having a larger sample size including entire vitamin D tool genes, among different ethnic groups may be conducted to elucidate molecular etiology of circulating 25(OH)D deficiency. The high prevalence of normal serum calcium and phosphate levels among vitamin D deficient subjects in this study coupled with the strikingly high prevalence of the deficiency at the national level, may suggest the need to revise the cut-off criteria for vitamin D deficiency in...
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Ashvin Varadharajan M K Sibin S V Athira Arijit Kumar Ghosh Pratibha Misra Source Type: research

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