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Nutrition: Vitamins
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Secretory Production of 7-dehydrocholesterol by Engineered Saccharomyces cerevisiae
CONCLUSION: Selective secretion of different sterol intermediates was characterized in sterol over-produced strain and the extracellular export of 7-DHC developed in present study significantly improved the cell biosynthetic capacity, which offered a novel modification idea for 7-DHC de novo biosynthesis by S. cerevisiae cell factory. This article is protected by copyright. All rights reserved.PMID:37688450 | DOI:10.1002/biot.202300056
Source: Biotechnology Journal - September 9, 2023 Category: Biotechnology Authors: Xia Ke Zi-Hao Pan Hong-Fei Du Yi Shen Ji-Dong Shen Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis
CONCLUSION: VDR inhibits ox-LDL-induced endothelial dysfunction and ferroptosis by regulating ADM transcription and acting on AMPK signaling pathway. Overexpression of VDR in Apoe-/- mice reduced lipid deposition and plaque area in the thoracic aorta of atherosclerotic mice.PMID:37688783 | DOI:10.1002/tox.23958
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Yanchao Hu Xu Gu Yan Zhang Weidong Ma Lijun Sun Congxia Wang Bincheng Ren Source Type: research
Secretory Production of 7-dehydrocholesterol by Engineered Saccharomyces cerevisiae
CONCLUSION: Selective secretion of different sterol intermediates was characterized in sterol over-produced strain and the extracellular export of 7-DHC developed in present study significantly improved the cell biosynthetic capacity, which offered a novel modification idea for 7-DHC de novo biosynthesis by S. cerevisiae cell factory. This article is protected by copyright. All rights reserved.PMID:37688450 | DOI:10.1002/biot.202300056
Source: Biotechnology Journal - September 9, 2023 Category: Biotechnology Authors: Xia Ke Zi-Hao Pan Hong-Fei Du Yi Shen Ji-Dong Shen Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview
Ageing Res Rev. 2023 Sep 7:102064. doi: 10.1016/j.arr.2023.102064. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes, affecting a significant proportion of those diagnosed with the disease, yet an effective treatment remains elusive. Vitamins have been extensively studied, emerging as a promising target for diagnosing and treating various systemic diseases, but their role in DPN is not known. This review collates and synthesizes knowledge regarding the interplay between vitamins and DPN, drawing on bibliographies from prior studies and relevant articles...
Source: Ageing Research Reviews - September 9, 2023 Category: Genetics & Stem Cells Authors: Kezheng Li Yinuo Chen Jiali Xie Weiwei Cai Chunyang Pang Can Cui Yu Huan Binbin Deng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview
Ageing Res Rev. 2023 Sep 7;91:102064. doi: 10.1016/j.arr.2023.102064. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes, affecting a significant proportion of those diagnosed with the disease, yet an effective treatment remains elusive. Vitamins have been extensively studied, emerging as a promising target for diagnosing and treating various systemic diseases, but their role in DPN is not known. This review collates and synthesizes knowledge regarding the interplay between vitamins and DPN, drawing on bibliographies from prior studies and relevant artic...
Source: Ageing Research Reviews - September 9, 2023 Category: Genetics & Stem Cells Authors: Kezheng Li Yinuo Chen Jiali Xie Weiwei Cai Chunyang Pang Can Cui Yu Huan Binbin Deng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Korean J Intern Med. 2023 Sep;38(5):583-594. doi: 10.3904/kjim.2023.035. Epub 2023 Sep 1.ABSTRACTIn the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have long been used as OACs, their inherent disadvantage of considerable bleeding complications has limited their use. NOACs demonstrate similar or superior clinical outcomes to those of warfarin. Although strict dose reduction criteria are recommended for NOACs, low-dose NOACs are frequently utilized, espe...
Source: The Korean Journal of Internal Medicine - September 8, 2023 Category: Internal Medicine Authors: Ki Hong Lee Hyung Wook Park Source Type: research
Role of vitamin D in management of diabetes and unresolved cardiovascular diseases
CONCLUSION: In this review, we present the most recent research on the effects of Vitamin D therapy on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.PMID:37680158 | DOI:10.2174/1573399820666230901151019
Source: Current Diabetes Reviews - September 8, 2023 Category: Endocrinology Authors: Prabhat Kumar Upadhyay Navneet Thakur Vishal Kumar Vishwakarma Ritesh Kumar Srivastav Tarique Mahmood Ansari Source Type: research
Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Korean J Intern Med. 2023 Sep;38(5):583-594. doi: 10.3904/kjim.2023.035. Epub 2023 Sep 1.ABSTRACTIn the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have long been used as OACs, their inherent disadvantage of considerable bleeding complications has limited their use. NOACs demonstrate similar or superior clinical outcomes to those of warfarin. Although strict dose reduction criteria are recommended for NOACs, low-dose NOACs are frequently utilized, espe...
Source: The Korean Journal of Internal Medicine - September 8, 2023 Category: Internal Medicine Authors: Ki Hong Lee Hyung Wook Park Source Type: research
Role of vitamin D in management of diabetes and unresolved cardiovascular diseases
CONCLUSION: In this review, we present the most recent research on the effects of Vitamin D therapy on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.PMID:37680158 | DOI:10.2174/1573399820666230901151019
Source: Current Diabetes Reviews - September 8, 2023 Category: Endocrinology Authors: Prabhat Kumar Upadhyay Navneet Thakur Vishal Kumar Vishwakarma Ritesh Kumar Srivastav Tarique Mahmood Ansari Source Type: research
Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Korean J Intern Med. 2023 Sep;38(5):583-594. doi: 10.3904/kjim.2023.035. Epub 2023 Sep 1.ABSTRACTIn the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have long been used as OACs, their inherent disadvantage of considerable bleeding complications has limited their use. NOACs demonstrate similar or superior clinical outcomes to those of warfarin. Although strict dose reduction criteria are recommended for NOACs, low-dose NOACs are frequently utilized, espe...
Source: The Korean Journal of Internal Medicine - September 8, 2023 Category: Internal Medicine Authors: Ki Hong Lee Hyung Wook Park Source Type: research
