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Total 9236 results found since Jan 2013.
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Federal Funding Cuts Loom for Immunization Programs
Am J Nurs. 2023 Oct 1;123(10):15. doi: 10.1097/01.NAJ.0000979060.62602.d0.ABSTRACTStates may lose up to 10% of their budgets for vaccinations.PMID:37732660 | DOI:10.1097/01.NAJ.0000979060.62602.d0
Source: The American Journal of Nursing - September 21, 2023 Category: Nursing Source Type: research
Standardized nomenclature of oral microorganisms in Chinese: the 2023 update
Zhonghua Kou Qiang Yi Xue Za Zhi. 2023 Sep 20;58:1045-1055. doi: 10.3760/cma.j.cn112144-20230816-00079. Online ahead of print.ABSTRACTOral microbial community, as an important part of human microbial community, is closely related to oral and general health. Oral microbiological research has become the forefront of international microbiological research. Standardized and unified nomenclature for oral microorganisms in Chinese is of great significance to support the development of oral medicine research. Standardized translation of microbial names is the basis for writing canonical and authoritative professional textbooks an...
Source: Shanghai Journal of Stomatology - September 20, 2023 Category: Dentistry Authors: Y Q Li X Peng B Ren F H Yan Y P Pan F Chen W B Du J G Liu Q Feng D Q Yang X J Huang Y H Pan Z Z Huang P H Ding K K Zhang H X Liu X D Zhou Source Type: research
Quality Contract for the Prevention of Postoperative Delirium
Anasthesiol Intensivmed Notfallmed Schmerzther. 2023 Sep;58(9):525-539. doi: 10.1055/a-2065-3806. Epub 2023 Sep 19.ABSTRACTDelirium is one of the most common postoperative complications. Delayed initiation of treatment leads to an increased mortality rate within the first 90 days and to an increased need for post-hospital care. Similarly, neurocognitive disorders (NCDs) occur in a quarter of affected patients over the long-term. The use of evidence-based guideline recommendations can reduce incidence rates of delirium, shorten delirium duration, and prevent complications. Implementing delirium management according to evide...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - September 19, 2023 Category: Intensive Care Authors: Fatima Y ürek Ursula Marschall Ursula Gaedigk Sinah Kr üger Moritz H öft Claudia Spies Source Type: research
International responses addressing the under-representation of older people in clinical research
This article provides an overview and critique of the current approaches to the inclusion of older people in clinical research and highlights policy gaps and limitations of current strategies.PMID:37724905 | DOI:10.1111/ajag.13234
Source: Australasian Journal on Ageing - September 19, 2023 Category: Geriatrics Authors: Susan C Markham Justin McNab Kate O'Loughlin Lindy Clemson Source Type: research
Ponderings on Peer Review: Part 3. Grant Critiques
The objective of stage 1 of the process is to establish the scientific merit of the grant proposal. For that phase, I discuss grant review panels, reviewer qualifications and responsibilities, how reviewers are identified and selected, pre-review meeting activities, activities during the review panel meeting, grant review criteria and scoring scales, and post-meeting activities. I also note 2 mechanisms that provide "pre-peer review" advice and recommendations for grant applications under development. I then describe the events associated with stage 2 of the peer review process in which grant funding agencies consider appl...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research
Bacillus Calmette-Gu érin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
EClinicalMedicine. 2023 Sep 11;64:102203. doi: 10.1016/j.eclinm.2023.102203. eCollection 2023 Oct.ABSTRACTBACKGROUND: Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects.METHODS: In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark ...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Laure F Pittet Cecilia L Moore Ellie McDonald Simone Barry Marc Bonten John Campbell Julio Croda Margareth Dalcolmo Andrew Davidson Mark W Douglas Kaya Gardiner Amanda Gwee Bruno Jardim Marcus V G Lacerda Michaela Lucas David J Lynn Laurens Manning Robert Source Type: research
Ponderings on Peer Review: Part 3. Grant Critiques
The objective of stage 1 of the process is to establish the scientific merit of the grant proposal. For that phase, I discuss grant review panels, reviewer qualifications and responsibilities, how reviewers are identified and selected, pre-review meeting activities, activities during the review panel meeting, grant review criteria and scoring scales, and post-meeting activities. I also note 2 mechanisms that provide "pre-peer review" advice and recommendations for grant applications under development. I then describe the events associated with stage 2 of the peer review process in which grant funding agencies consider appl...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research
Bacillus Calmette-Gu érin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
EClinicalMedicine. 2023 Sep 11;64:102203. doi: 10.1016/j.eclinm.2023.102203. eCollection 2023 Oct.ABSTRACTBACKGROUND: Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects.METHODS: In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark ...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Laure F Pittet Cecilia L Moore Ellie McDonald Simone Barry Marc Bonten John Campbell Julio Croda Margareth Dalcolmo Andrew Davidson Mark W Douglas Kaya Gardiner Amanda Gwee Bruno Jardim Marcus V G Lacerda Michaela Lucas David J Lynn Laurens Manning Robert Source Type: research
Ponderings on Peer Review: Part 3. Grant Critiques
The objective of stage 1 of the process is to establish the scientific merit of the grant proposal. For that phase, I discuss grant review panels, reviewer qualifications and responsibilities, how reviewers are identified and selected, pre-review meeting activities, activities during the review panel meeting, grant review criteria and scoring scales, and post-meeting activities. I also note 2 mechanisms that provide "pre-peer review" advice and recommendations for grant applications under development. I then describe the events associated with stage 2 of the peer review process in which grant funding agencies consider appl...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research
Long-term incidence of haematological cancer after bariatric surgery or usual care in the Swedish Obese Subjects study: a prospective cohort study
This study is registered with ClinicalTrials.gov (NCT01479452) and is ongoing.FINDINGS: A total of 4047 individuals with obesity were enrolled between Sept 1, 1987, and Jan 31, 2001. Overall, 34 participants in the surgery group and 51 participants in the usual care control group were diagnosed with haematological cancer during follow-up (hazard ratio [HR] 0·60; 95% CI 0·39-0·92; p=0·020). Moreover, there were three deaths by haematological cancer in the surgery group and 13 deaths in the control group (0·22; 0·06-0·76; p=0·017). Surgery was also associated with a reduced incidence of lymphoma (0·45; 0·23-0·88; ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Kajsa Sj öholm Johanna C Andersson-Assarsson Felipe M Kristensson Stephan Hjorth Hege Gravdahl Garelius Peter Jacobson Per-Arne Svensson Sofie Ahlin Bj örn Carlsson Markku Peltonen Lena M S Carlsson Magdalena Taube Source Type: research
The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research
Factors Influencing Parental Satisfaction in Children with Cleft Lip and Palate Repair Based on Comprehensive Plastic Surgery Procedures at the Senyum Bali Foundation
Cleft Palate Craniofac J. 2023 Sep 14:10556656231201835. doi: 10.1177/10556656231201835. Online ahead of print.ABSTRACTAnalyze contributing factors toward satisfaction after cleft lip and palate treatments in Senyum Bali Foundation. Qualitative case study, an interview with a semi-structured question from February to April 2023 by purposive sampling informants including parents, foundation staff, and plastic surgeon. Unsatisfying nose and teeth appearance due imperfect effects after surgery and requirement of more procedures. Mini model theory study that includes the appearance of the face and lips; speech and hearing; the...
Source: The Cleft Palate-Craniofacial Journal - September 15, 2023 Category: ENT & OMF Authors: Tiesya Padmasari Ardi Ardi Source Type: research
The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research
