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Nutrition: Calcium
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Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
A microfluidic array enabling generation of identical biochemical stimulating signals to trapped biological cells for single-cell dynamics
In this study, we introduce a novel radially distributed single-cell trapping microfluidic array, designed to quantitatively and consistently apply identical biochemical stimulating signals to each trapped cell. Numerical simulations were employed to optimize microchannel geometry, enhancing trapping efficiency while minimizing signal distortion. Experimental validation demonstrated the trapping success rate and the single-cell trapping efficiency exceeding 99% and 85%, respectively. The microarray's capability to deliver identical dynamic biochemical stimulating signals, with various waveforms, to each unit was confirmed ...
Source: Talanta - September 12, 2023 Category: Chemistry Authors: Miao Yu Yong-Jiang Li Yu-Nong Yang Chun-Dong Xue Gui-Yang Xin Bo Liu Kai-Rong Qin Source Type: research
Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1
Dev Cell. 2023 Sep 2:S1534-5807(23)00408-2. doi: 10.1016/j.devcel.2023.08.012. Online ahead of print.ABSTRACTAs evolutionarily conserved organelles, lipid droplets (LDs) carry out numerous functions and have various subcellular localizations in different cell types and species. In avian cone cells, there is a single apically localized LD. We demonstrated that CIDEA (cell death inducing DFFA like effector a) and microtubules promote the formation of the single LD in chicken cone cells. Centrins, which are well-known centriole proteins, target to the cone cell LD via their C-terminal calcium-binding domains. Centrins localiz...
Source: Developmental Cell - September 12, 2023 Category: Cytology Authors: Huimin Pan Yaqiang Qin Jinglin Zhu Wei Wang Zhonghua Liu Xiahe Huang Sin Man Lam Guanghou Shui Yingchun Wang Yuqiang Jiang Xun Huang Source Type: research
A microfluidic array enabling generation of identical biochemical stimulating signals to trapped biological cells for single-cell dynamics
In this study, we introduce a novel radially distributed single-cell trapping microfluidic array, designed to quantitatively and consistently apply identical biochemical stimulating signals to each trapped cell. Numerical simulations were employed to optimize microchannel geometry, enhancing trapping efficiency while minimizing signal distortion. Experimental validation demonstrated the trapping success rate and the single-cell trapping efficiency exceeding 99% and 85%, respectively. The microarray's capability to deliver identical dynamic biochemical stimulating signals, with various waveforms, to each unit was confirmed ...
Source: Talanta - September 12, 2023 Category: Chemistry Authors: Miao Yu Yong-Jiang Li Yu-Nong Yang Chun-Dong Xue Gui-Yang Xin Bo Liu Kai-Rong Qin Source Type: research
Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1
Dev Cell. 2023 Sep 2:S1534-5807(23)00408-2. doi: 10.1016/j.devcel.2023.08.012. Online ahead of print.ABSTRACTAs evolutionarily conserved organelles, lipid droplets (LDs) carry out numerous functions and have various subcellular localizations in different cell types and species. In avian cone cells, there is a single apically localized LD. We demonstrated that CIDEA (cell death inducing DFFA like effector a) and microtubules promote the formation of the single LD in chicken cone cells. Centrins, which are well-known centriole proteins, target to the cone cell LD via their C-terminal calcium-binding domains. Centrins localiz...
Source: Developmental Cell - September 12, 2023 Category: Cytology Authors: Huimin Pan Yaqiang Qin Jinglin Zhu Wei Wang Zhonghua Liu Xiahe Huang Sin Man Lam Guanghou Shui Yingchun Wang Yuqiang Jiang Xun Huang Source Type: research
Efficacy and safety of drug therapy for the prevention and treatment of chemotherapy-induced peripheral neuropathy: a protocol for a systematic review and network meta-analysis
This article describes a protocol for evaluating the efficacy and safety of drug therapy for the prevention and treatment of CIPN. The results of the proposed systematic review with network meta-analysis (NMA) will provide new insights into the prevention and treatment of CIPN.
Methods and analysis
We will conduct a literature search in MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov to find relevant articles published through January 2023. We will include studies that investigated the efficacy and safety of vitamin B12, goshajinkigan, non-steroidal anti-inflammatory analgesi...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Sato, M. T., Hasegawa, T., Noma, H., Sugita, H., Ota, E. Tags: Open access, Oncology Source Type: research
Sensors for in situ monitoring of oral and dental health parameters in saliva
ConclusionsSaliva ’s complex and dynamic structure as well as bioadhesion are key challenges and should be addressed in the future developments. Consequently, more studies that focus particularly on biofouling processes and interferential effects of the salivary matrix components on sensor surfaces are required.Clinical relevanceBy monitoring fluids in the oral cavity, as the entrance to the digestive system, extensive information can be obtained regarding the effects of foods and preventive agents on the oral microbiota and the tooth surfaces. This may lead to a better understanding of strategies to modulate oral and general health.
Source: Clinical Oral Investigations - September 12, 2023 Category: Dentistry Source Type: research
“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE
When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering:
Planetary Boundaries
Earth Systems
Human Perturbations
Planetary Scale Destabilization
Holocene Epoch vs. Anthropogenic Epoch
These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs
Amlodipine downregulates gene expression that involved in the signaling pathways of coagulation process in COVID-19 patients: An observational clinical study
This study was carried out in the Department of Pharmacy at Al-Kut University College in Wasit, Iraq, in conjunction with Al Zahraa Hospital from June 2021 to March 2022. A total of 45 COVID-19 patients participated in this study who were grouped into as follows: Group I (n = 23) who had no previous history of hypertension and Group II (n = 22) who had previous hypertension and were treated with amlodipine. Expression of the calcium-sensing receptor (CaSR), coagulation factor V (F5), and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 Like (MTHFD1L) genes was determined. P values were calculated by Chi-square t...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Zainab A Abbood Zainab H Ajeel Marwah S Joudah Marwan Salih M Al-Nimer Ahmed Hamza Al-Shammari Source Type: research
Down-regulation of the mitochondrial fusion protein Opa1/Mfn2 promotes cardiomyocyte hypertrophy in Su5416/hypoxia-induced pulmonary hypertension rats
CONCLUSIONS: The down-regulation of mitochondrial fusion protein Opa1/Mfn2 can accelerate cardiomyocyte hypertrophy and then participate in maladaptive RV remodeling in SuHx-induced PH rats, which may be potential targets for preventing maladaptive RV remodeling.PMID:37696382 | DOI:10.1016/j.abb.2023.109743
Source: Archives of Biochemistry and Biophysics - September 11, 2023 Category: Biochemistry Authors: Fangmei Luo Minyi Fu Ting Wang Yanan Qi Xuefeng Zhong Dai Li Bin Liu Source Type: research
Evaluation of Long-Term Nutrition Outcomes After Duodenal Switch: A Systematic Review and Meta-Analysis
CONCLUSIONS: Despite displaying comparable nutrition-related outcomes to mid-term follow-up, our study demonstrated that BPD-DS could result in a high level of long-term nutrition deficiency after BPD-DS for selected patients. However, further randomized controlled studies with standardized supplementation regimens and improvement in compliance are necessary to evaluate and prevent long-term nutritional deficiencies after BPD-DS.PMID:37694730 | DOI:10.1177/00031348231201886
Source: The American Surgeon - September 11, 2023 Category: Surgery Authors: Hayato Nakanishi Kamal Abi Mosleh Mohammad Al-Kordi Katie Marrero Mohammad Kermansaravi S Scott Davis Benjamin Clapp Omar M Ghanem Source Type: research
Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis
Endocrinology. 2023 Sep 11:bqad137. doi: 10.1210/endocr/bqad137. Online ahead of print.ABSTRACTPrimary hyperparathyroidism (PHPT) is a common endocrinopathy for which several pathogenic mechanisms, including cyclin D1 overexpression, have been identified. Vitamin D nutritional status may influence parathyroid tumorigenesis, but evidence remains circumstantial. To assess the potential influence of vitamin D insufficiency/deficiency on initiation or progression of parathyroid tumorigenesis, we superimposed vitamin D insufficiency or deficiency on parathyroid tumor-prone PTH-cyclin D1 transgenic mice. Mice were placed on diet...
Source: Endocrinology - September 11, 2023 Category: Endocrinology Authors: Jessica Costa-Guda Kristin Corrado Justin Bellizzi Elizabeth Saria Kirsten Saucier Miriam Guemes-Aragon Guntas Kakar Madison Rose Melanie Pascal Cynthia Alander Sanjay M Mallya Andrew Arnold Source Type: research
A Review on the Cytotoxicity and Antibacterial Effect of Marine Organisms of Persian Gulf
Adv Biomed Res. 2023 Jul 27;12:195. doi: 10.4103/abr.abr_290_22. eCollection 2023.ABSTRACTMarine organisms contain several natural products and bioactive compounds, including hydrolyzed proteins, antioxidant peptides, gelatin, collagen, ω-3 unsaturated fatty acids, vitamin A, vitamin D, calcium phosphate, hydroxyapatite, chitosan, lectin, and various toxins. They can inhibit diverse diseases, be used in pharmaceutical compounds, or as antibiotics and pigments. In this regard, these microorganisms are of crucial medicinal and economical importance. Thanks to new technologies and advanced laboratory methods, bioactive compo...
Source: Biomed Res - September 11, 2023 Category: Research Authors: Seyed Erfan Mousavi Sheyda Razaghi Nafiseh Emami Afsaneh Yegdaneh Source Type: research
Comparison of Blood Lead Levels in Children and Adolescents with and without Functional Abdominal Pain
CONCLUSION: We found that the lead level was higher in patients with FGID than in the controls; however, this difference was not significantly different. This might be because of elevated lead levels in both groups. Future ecological studies with a large sample size are necessary in this regard.PMID:37694233 | PMC:PMC10492617 | DOI:10.4103/abr.abr_250_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Fatemeh Famouri Maryam Yazdi Awat Feizii Hossein Saneian Peiman Nasri Roya Kelishadi Source Type: research
Efficacy and Safety of Upacicalcet in Hemodialysis Patients with Secondary Hyperparathyroidism: A Randomized Placebo-Controlled Trial
CONCLUSIONS: Upacicalcet, a novel injectable calcimimetic, is effective and safe for secondary hyperparathyroidism patients receiving HD.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Phase 3 Study of SK-1403, NCT03801980.PMID:37696667 | DOI:10.2215/CJN.0000000000000253
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 11, 2023 Category: Urology & Nephrology Authors: Takashi Shigematsu Fumihiko Koiwa Yoshitaka Isaka Masafumi Fukagawa Keiko Hagita Yukihisa S Watanabe Daisuke Honda Tadao Akizawa Source Type: research
