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Infectious Disease: Tuberculosis
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Total 20241 results found since Jan 2013.
Toward the early diagnosis of tuberculosis: A gold particle-decorated graphene-modified paper-based electrochemical biosensor for Hsp16.3 detection
Talanta. 2023 Sep 14;267:125210. doi: 10.1016/j.talanta.2023.125210. Online ahead of print.ABSTRACTTuberculosis (TB) currently remains a major life-threatening disease as it can be fatal if not treated properly or in a timely manner. Herein, we first describe a disposable and cost-effective paper-based electrochemical biosensor based on a gold particle-decorated carboxyl graphene (AuPs/GCOOH)-modified electrode for detecting heat shock protein (Hsp16.3), which is a specific biomarker indicating the onset of TB infection. The device pattern was first engineered to facilitate detection procedures and printed on low-cost filt...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Thimpika Pornprom Naruedon Phusi Paptawan Thongdee Bongkochawan Pakamwong Jidapa Sangswan Pharit Kamsri Auradee Punkvang Khomson Suttisintong Jiraporn Leanpolchareanchai Poonpilas Hongmanee Putthapoom Lumjiaktase Sakda Jampasa Orawon Chailapakul Pornpan P Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Haemophagocytic lymphohistiocytosis secondary to disseminated tuberculosis in a young adult with Crohn's disease
Med J Aust. 2023 Sep 15. doi: 10.5694/mja2.52103. Online ahead of print.NO ABSTRACTPMID:37712106 | DOI:10.5694/mja2.52103
Source: Med J Aust - September 15, 2023 Category: General Medicine Authors: Rattanak Visal Hean David A Sheffield Kirsten Herbert David Brewster Source Type: research
Host cell environments and antibiotic efficacy in tuberculosis
Trends Microbiol. 2023 Sep 12:S0966-842X(23)00253-6. doi: 10.1016/j.tim.2023.08.009. Online ahead of print.ABSTRACTThe aetiologic agent of tuberculosis (TB), Mycobacterium tuberculosis (Mtb), can survive, persist, and proliferate in a variety of heterogeneous subcellular compartments. Therefore, TB chemotherapy requires antibiotics crossing multiple biological membranes to reach distinct subcellular compartments and target these bacterial populations. These compartments are also dynamic, and our understanding of intracellular pharmacokinetics (PK) often represents a challenge for antitubercular drug development. In recent ...
Source: Trends in Microbiology - September 14, 2023 Category: Microbiology Authors: Nathan J Day Pierre Santucci Maximiliano G Gutierrez Source Type: research
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Cell Mol Life Sci. 2023 Sep 14;80(10):291. doi: 10.1007/s00018-023-04914-5.ABSTRACTLipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription. Tran...
Source: Cellular and Molecular Life Sciences : CMLS - September 13, 2023 Category: Cytology Authors: Hagyu Kim Sung Jae Shin Source Type: research
Evaluation of machine learning classifiers for predicting essential genes in < em > Mycobacterium tuberculosis < /em > strains
Bioinformation. 2022 Dec 31;18(12):1126-1130. doi: 10.6026/973206300181126. eCollection 2022.ABSTRACTAccurate investigation and prediction of essential genes from bacterial genome is very important as it might be explored in effective targets for antimicrobial drugs and understanding biological mechanism of a cell. A subset of key features data obtained from 14 genome sequence-based features of 20 strains of Mycobacterium tuberculosis bacteria whose essential gene information was downloaded from ePath and NCBI database for mapping and matching essential genes by using a genome extraction program. The selection of key featu...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Monish Mukul Das Keka Sarkar Source Type: research
CROI 2023: Tuberculosis and Infectious Complications in Persons With HIV
Top Antivir Med. 2023 Jun 30;31(4):529-537.ABSTRACTNovel implementation strategies to increase uptake and adherence to tuberculosis (TB) preventive therapy hold promise for reducing TB incidence in persons with HIV in high-burden settings. In persons who develop drug-susceptible TB, progress to shorten TB treatment continues to be made with the introduction of new drugs and novel treatment strategies that could allow for treatment shortening to 2 months for most people. A global case series provided powerful evidence that mpox should be considered an HIV-related opportunistic infection given its severe manifestations and p...
Source: Topics in HIV Medicine - September 13, 2023 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research
