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Infectious Disease: Tuberculosis
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Total 20241 results found since Jan 2013.
Genetic surveillance and outcomes of pyrazinamide and fluoroquinolones-resistant tuberculosis in Taiwan
CONCLUSION: We concluded that routine PZA and FQ susceptibility tests are recommended for guiding the treatment of TB.PMID:37690869 | DOI:10.1016/j.jmii.2023.08.013
Source: Journal of Microbiology, Immunology, and Infection - September 10, 2023 Category: Microbiology Authors: Hsin-Ting Huang Wan-Hsuan Lin Tai-Hua Chan Ruwen Jou Source Type: research
Seeing is believing: Efficiency evaluation of multifunctional ionic-dependent AIEgens for tuberculosis
In this study, we report two cationic aggregation-inducing emission luminogens (AIEgens) named TTVP and TTPy, which have different functional charged moieties, to investigate their potential for simultaneous tracing and photodynamic therapy in TB infection. TTVP and TTPy exhibit intrinsic positive charges, excellent water solubility, and near-infrared (NIR) emission. Based on ionic-function relationships, TTVP, with more positive charges, demonstrates a stronger binding affinity to Mycobacterium marinum (M.m), (a close genetic relative of Mtb), compared to TTPy. Both TTVP and TTPy exhibit high efficiency in generating reac...
Source: Biomaterials - September 10, 2023 Category: Materials Science Authors: Xueni Huang Chengshengze Chu Chunzi Shi Jiulong Zhang Bo Yan Fei Shan Dong Wang Yuxin Shi Chen Peng Ben Zhong Tang Source Type: research
Genetic surveillance and outcomes of pyrazinamide and fluoroquinolones-resistant tuberculosis in Taiwan
CONCLUSION: We concluded that routine PZA and FQ susceptibility tests are recommended for guiding the treatment of TB.PMID:37690869 | DOI:10.1016/j.jmii.2023.08.013
Source: Journal of Microbiology, Immunology, and Infection - September 10, 2023 Category: Microbiology Authors: Hsin-Ting Huang Wan-Hsuan Lin Tai-Hua Chan Ruwen Jou Source Type: research
Seeing is believing: Efficiency evaluation of multifunctional ionic-dependent AIEgens for tuberculosis
In this study, we report two cationic aggregation-inducing emission luminogens (AIEgens) named TTVP and TTPy, which have different functional charged moieties, to investigate their potential for simultaneous tracing and photodynamic therapy in TB infection. TTVP and TTPy exhibit intrinsic positive charges, excellent water solubility, and near-infrared (NIR) emission. Based on ionic-function relationships, TTVP, with more positive charges, demonstrates a stronger binding affinity to Mycobacterium marinum (M.m), (a close genetic relative of Mtb), compared to TTPy. Both TTVP and TTPy exhibit high efficiency in generating reac...
Source: Biomaterials - September 10, 2023 Category: Materials Science Authors: Xueni Huang Chengshengze Chu Chunzi Shi Jiulong Zhang Bo Yan Fei Shan Dong Wang Yuxin Shi Chen Peng Ben Zhong Tang Source Type: research
Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin
Int J Biol Macromol. 2023 Sep 6:126771. doi: 10.1016/j.ijbiomac.2023.126771. Online ahead of print.ABSTRACTAntibiotics form our frontline therapy against disease-causing bacteria. Unfortunately, antibiotic resistance is becoming more common, threatening a future where these medications can no longer cure infections. Furthermore, the emergence of multidrug-resistant (MDR), totally drug-resistant (TDR), and extensively drug-resistant (XDR) tuberculosis has increased the urgency of discovering new therapeutic leads with unique modes of action. Some natural peptides derived from actinomycetes, such as Cyclomarin A, Lassomycin,...
Source: International Journal of Biological Macromolecules - September 8, 2023 Category: Biochemistry Authors: Manas K Jagdev Dharma R Tompa Losee L Ling Aaron J Peoples Jagneshwar Dandapat Chinmayee Mohapatra Kim Lewis Dileep Vasudevan Source Type: research
Clinical features of infectious uveitis in a Tunisian population
CONCLUSION: This study highlighted the causes and clinical features of IU in our setting. Tuberculosis remains one of its most frequent etiologies in Tunisia. However, a larger multicenter national study would allow a more precise evaluation.PMID:37682270
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Rym Maamouri Meriam Beldi Yasmine Houman Mehdi Somai Fatma Boussema Monia Cheour Source Type: research
Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin
Int J Biol Macromol. 2023 Sep 6;253(Pt 2):126771. doi: 10.1016/j.ijbiomac.2023.126771. Online ahead of print.ABSTRACTAntibiotics form our frontline therapy against disease-causing bacteria. Unfortunately, antibiotic resistance is becoming more common, threatening a future where these medications can no longer cure infections. Furthermore, the emergence of multidrug-resistant (MDR), totally drug-resistant (TDR), and extensively drug-resistant (XDR) tuberculosis has increased the urgency of discovering new therapeutic leads with unique modes of action. Some natural peptides derived from actinomycetes, such as Cyclomarin A, L...
Source: International Journal of Biological Macromolecules - September 8, 2023 Category: Biochemistry Authors: Manas K Jagdev Dharma R Tompa Losee L Ling Aaron J Peoples Jagneshwar Dandapat Chinmayee Mohapatra Kim Lewis Dileep Vasudevan Source Type: research
Intricate link between siderophore secretion and drug efflux in < em > Mycobacterium tuberculosis < /em >
In this study, we show that M. tuberculosis mutants lacking components of the MmpS4-MmpL4 and MmpS5-MmpL5 systems are more susceptible to bedaquiline, clofazimine, and rifabutin, important drugs for treatment of drug-resistant TB. While genetic deletion experiments revealed similar functions of the MmpL4 and MmpL5 transporters in siderophore and drug secretion, complementation experiments indicated that the MmpS4-MmpL4 proteins alone are not sufficient to restore drug efflux in an M. tuberculosis mutant lacking both operons, in contrast to MmpS5-MmpL5. Importantly, an M. tuberculosis mutant lacking the recently discovered ...
Source: Antimicrobial Agents and Chemotherapy - September 7, 2023 Category: Microbiology Authors: Virginia Meikle Lei Zhang Michael Niederweis Source Type: research
Exploring recombinant secretory proteins from Mycobacterium tuberculosis to develop a serological platform for tuberculosis diagnosis
Int J Biol Macromol. 2023 Sep 5:126769. doi: 10.1016/j.ijbiomac.2023.126769. Online ahead of print.ABSTRACTThe lack of a sensitive diagnostic tool for tuberculosis (TB) is the main reason for increasing cause of death in many developing countries. The routine diagnostic tests are either time-consuming or equivocal in terms of results. Hence, there is a need for quicker and accurate diagnostic tests. Certain studies have documented the usage of proteins secreted by Mycobacterium tuberculosis (MTB) in developing a sensitive tool for diagnosing TB. The study aimed to employ PPE41, MPT53, LPQH, CFP10, ESAT6 and TB18.5 proteins...
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Gopinath Ramalingam Selvaraj Jayaraman Javed Masood Khan Mohammad Z Ahmed Anis Ahmad Elanchezhiyan Manickan Ponnulakshmi Rajagopal Source Type: research
Intricate link between siderophore secretion and drug efflux in < em > Mycobacterium tuberculosis < /em >
In this study, we show that M. tuberculosis mutants lacking components of the MmpS4-MmpL4 and MmpS5-MmpL5 systems are more susceptible to bedaquiline, clofazimine, and rifabutin, important drugs for treatment of drug-resistant TB. While genetic deletion experiments revealed similar functions of the MmpL4 and MmpL5 transporters in siderophore and drug secretion, complementation experiments indicated that the MmpS4-MmpL4 proteins alone are not sufficient to restore drug efflux in an M. tuberculosis mutant lacking both operons, in contrast to MmpS5-MmpL5. Importantly, an M. tuberculosis mutant lacking the recently discovered ...
Source: Antimicrobial Agents and Chemotherapy - September 7, 2023 Category: Microbiology Authors: Virginia Meikle Lei Zhang Michael Niederweis Source Type: research
Exploring recombinant secretory proteins from Mycobacterium tuberculosis to develop a serological platform for tuberculosis diagnosis
Int J Biol Macromol. 2023 Sep 5:126769. doi: 10.1016/j.ijbiomac.2023.126769. Online ahead of print.ABSTRACTThe lack of a sensitive diagnostic tool for tuberculosis (TB) is the main reason for increasing cause of death in many developing countries. The routine diagnostic tests are either time-consuming or equivocal in terms of results. Hence, there is a need for quicker and accurate diagnostic tests. Certain studies have documented the usage of proteins secreted by Mycobacterium tuberculosis (MTB) in developing a sensitive tool for diagnosing TB. The study aimed to employ PPE41, MPT53, LPQH, CFP10, ESAT6 and TB18.5 proteins...
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Gopinath Ramalingam Selvaraj Jayaraman Javed Masood Khan Mohammad Z Ahmed Anis Ahmad Elanchezhiyan Manickan Ponnulakshmi Rajagopal Source Type: research
Glycated Haemoglobin Trajectories and their Association with Treatment Outcomes among Pulmonary Tuberculosis Cases in India - A Prospective Cohort Study
Chest. 2023 Sep 4:S0012-3692(23)05377-1. doi: 10.1016/j.chest.2023.08.026. Online ahead of print.ABSTRACTBACKGROUND: Transient hyperglycemia is commonly seen during tuberculosis treatment, yet its association with unfavorable treatment outcomes is unclear.RESEARCH QUESTION: Is there an association between glycated Haemoglobin (HbA1c) trajectories and tuberculosis treatment outcomes?STUDY DESIGN AND METHODS: Adults with pulmonary tuberculosis were prospectively evaluated for 18 months after their second HbA1c measurement. HbA1c trajectories during the initial three months of treatment were defined as follows - Persistent eu...
Source: Chest - September 6, 2023 Category: Respiratory Medicine Authors: Geeta Pardeshi Vidya Mave Sanjay Gaikwad Dileep Kadam Madhusudan Barthwal Nikhil Gupte Sachin Atre Sona Deshmukh Jonathan E Golub Akshay Gupte Source Type: research
Multilayer precision-based screening of potential inhibitors targeting Mycobacterium tuberculosis acetate kinase using in silico approaches
Comput Biol Chem. 2023 Aug 23;107:107942. doi: 10.1016/j.compbiolchem.2023.107942. Online ahead of print.ABSTRACTTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major threat to global health, with the emergence of multi-drug and extensively drug-resistant strains posing a serious challenge. Thereby, understanding the molecular basis of MTB virulence and disease pathogenesis is critical for developing effective therapeutic strategies. Targeting proteins involved in central metabolism has been recognized as a promising therapeutic approach to combat MTB. In this regard, the enzyme AckA of the acetate...
Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Sneha Subramaniyan Hemavathy Nagarajan Umashankar Vetrivel Jeyakanthan Jeyaraman Source Type: research
