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Total 4438246 results found since Jan 2013.
Did COVID-19 Change the Availability and Use of Clean Energy for Cooking? Evidence From Ghana
This study provides insights that could be valuable in future understanding of the interactions between pandemic control measures and economic disruptions that may affect household energy choices for cooking.PMID:37736574 | PMC:PMC10510355 | DOI:10.1177/11786302231198854
Source: Environmental Health Insights - September 22, 2023 Category: Environmental Health Authors: Rebecca Kd Prah Darby Jack Theresa Tawiah Seidu Iddrisu Sulemana Watara Abubakari Mohammed Nuhu Mujtaba Richard Joshua Tetteh Stephaney Gyaase Mieks Twumasi Jason Saah Joseph Wilson Sheila Addo Daniel Pope Kwaku Poku Asante Elisa Puzzolo Source Type: research
Findings of Research Misconduct
Fed Regist. 2023 Sep 1;88(169):60466-60467.NO ABSTRACTPMID:37736656 | PMC:PMC10473901
Source: Fed Regist - September 22, 2023 Category: American Health Source Type: research
Depletion of mTOR ameliorates CD < sub > 4 < /sub > < sup > + < /sup > T cell pyroptosis by promoting autophagy activity in septic mice
In this study, a septic mouse model was developed using cecal ligation and puncture (CLP) to explore the degree of pyroptosis and autophagy of CD4+ T cells. T-cell-specific mTOR/TSC1-knockout mice were used to investigate the role of mTOR pathway in the regulation of CD4+ T cell pyroptosis. Bafilomycin, a specific autophagy inhibitor, was used to verify the regulatory effect of autophagy on pyroptosis in septic mice. We observed aggravated pyroptosis in CD4+ T cells in CLP mice accompanied by impaired autophagy activity and an overactivated mTOR signaling pathway. Depletion of mTOR relieved autophagy deficiency and reduced...
Source: International Immunopharmacology - September 22, 2023 Category: Allergy & Immunology Authors: Ran Guo Guoyu Zhao Guangxu Bai Jianwei Chen Wen Han Na Cui Hao Wang Source Type: research
Interdisciplinary collaboration in the diagnosis and management of chronic cough: the role and importance of primary care providers
The objective of this review is to describe the role of PCPs in the diagnosis and treatment of CC in adults. This narrative review draws upon literature (identified via a PubMed search performed January 9, 2023, using primary care/disease state-related terms) and expertise from specialist physicians to provide recommendations for CC management in primary care. Cough is one of the top reasons patients seek care from PCPs; accordingly, PCPs are often the first physicians to conduct workup and initiate treatment. Patients with CC often experience a burdensome cough that lasts for years, have high healthcare resource utilizati...
Source: Current Medical Research and Opinion - September 22, 2023 Category: Research Authors: Peter V Dicpinigaitis Kenneth W Altman Isil Ulger Isci Xuehua Ke Michael Blaiss Source Type: research
Meta-analysis of primary care delivered buprenorphine treatment retention outcomes
Conclusions: While we only investigate BT through primary care, our findings indicate retention rates are equivalent to the rates reported in the specialty care literature. More work is needed to examine factors that may impact primary care delivered BT specifically and differentiate participants that may benefit from care delivered in specialty over primary care as well as the converse.PMID:37737714 | DOI:10.1080/00952990.2023.2251653
Source: The American Journal of Drug and Alcohol Abuse - September 22, 2023 Category: Addiction Authors: Robert L Cooper Ryan D Edgerton Julia Watson Nicholas Conley William A Agee Derek M Wilus Samuel A MacMaster Lisa Bell Parul Patel Amruta Godbole Cynthia Bass-Thomas Aramandla Ramesh Mohammad Tabatabai Source Type: research
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
In this study, we examined the role of TRPML1 (TRP cation channel, mucolipin subfamily, member 1) in regulating the homeostasis of secretory lysosomes and their cross-talk with mitochondria in human NK cells. We found that genetic deletion of TRPML1, which localizes to lysosomes in NK cells, led to mitochondrial fragmentation with evidence of collapsed mitochondrial cristae. Consequently, TRPML1-/- NK92 (NK92ML1-/-) displayed loss of mitochondrial membrane potential, increased reactive oxygen species stress, reduced ATP production, and compromised respiratory capacity. Using sensitive organelle-specific probes, we observed...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Dennis Clement Edina K Szabo Silje Zandstra Krokeide Merete Thune Wiiger Marianna Vincenti Daniel Palacios Young-Tae Chang Christian Grimm Sandip Patel Harald Stenmark Andreas Brech Rakesh Kumar Majhi Karl-Johan Malmberg Source Type: research
Mass Spectrometric Profiling of HLA-B44 Peptidomes Provides Evidence for Tapasin-Mediated Tryptophan Editing
J Immunol. 2023 Sep 22:ji2300232. doi: 10.4049/jimmunol.2300232. Online ahead of print.ABSTRACTThe extreme polymorphisms of HLA class I proteins result in structural variations in their peptide binding sites to achieve diversity in Ag presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assembly factor tapasin were assessed for HLA-B*44:05 (Y116) and a close variant, HLA-B*44:02 (D116), which have low and high tapasin dependence, respectively, for their cell surface expression. Analyses of the HLA-B*44:05 peptidomes in the presence and absence of tapasin...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Amanpreet Kaur Avrokin Surnilla Anita J Zaitouna Michael B Mumphrey Venkatesha Basrur Irina Grigorova Marcin Cieslik Mary Carrington Alexey I Nesvizhskii Malini Raghavan Source Type: research
Opioid Prescribing Habits of Emergency Department Providers in Response to an Educational Intervention
CONCLUSION: Overall, the educational intervention on the topic of opioid prescribing guidelines did not have the expected impact on amounts of opioids administered or prescribed during the study period. Total opioids utilized and opioids prescribed did not vary between the pre- and post-intervention groups overall, by subset diagnosis, or by provider. There was, however, an increase in utilization of non-opioid treatments that could be indicative of a partial response to the educational intervention. This study showed that long-term effects of education regarding recommended opioid utilization might be less effective than ...
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Tory Makela Source Type: research
Patients with fibromyalgia in Finnish healthcare center - one-year follow up
CONCLUSION: With these results, we cannot conclude that ÖMPSQ predicts the patient's severity of symptoms. On the contrary, we can conclude that antidepressants and/or psychological therapy might reduce fibromyalgia symptoms for depressed patients with fibromyalgia. Patients with fibromyalgia might benefit from clinical evaluation and modifications to the treatment plan if necessary.PMID:37738389 | DOI:10.1080/02813432.2023.2259960
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Tommi J ärvinen Aleksi Varinen Markku Sumanen Source Type: research
Genetic Disorders in Pediatric Rheumatology Clinic: When to Suspect, and Why?
Indian J Pediatr. 2023 Sep 22. doi: 10.1007/s12098-023-04845-w. Online ahead of print.ABSTRACTJust under a decade ago, most children with genetic disorders received a phenotypic diagnosis, often by atlas matching. With advances in genomics (decoding of human genome, easy availability of genetic testing, and reduction in cost of tests), genotypic diagnosis is now a reality. Genetic diseases can lead to non-inflammatory arthritis that can mimic juvenile idiopathic arthritis (JIA). A small but growing number (as newer genes are discovered) of genetic diseases are being diagnosed in children with a seemingly inflammatory muscu...
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Naziya Perveen Maldar Raju Khubchandani Archana Khan Source Type: research
Gender-specific results of the Dresden children and adolescents headache program DreKiP
We examined gender differences in the outpatient multimodal Dresden Child and Adolescent Headache Program DreKiP.METHODS: We treated 140 patients with primary headache in a 15-hour structured group program. At baseline (T0) and six (T1) and twelve months (T2) after the end of the program, data on headache-related limitation of daily activities (PedMIDAS) as well as headache frequency, intensity, and pain-related disability (P-PDI) were collected. Retrospectively, these data were analyzed separately for girls and boys.RESULTS: For 91 patients (9-19 years, median = 15; 71.4 % female) data were available for at least two meas...
Source: Schmerz - September 22, 2023 Category: Anesthesiology Authors: Laura Zaranek Hanna Sobe Matthias Richter Anke H übler Reinhard Berner Maja von der Hagen Thea Koch Rainer Sabatowski Anna Klimova Gudrun Go ßrau Source Type: research
Im Team Grenzen überwinden
Schmerz. 2023 Sep 22. doi: 10.1007/s00482-023-00753-2. Online ahead of print.NO ABSTRACTPMID:37736817 | DOI:10.1007/s00482-023-00753-2
Source: Schmerz - September 22, 2023 Category: Anesthesiology Source Type: research
