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Therapy: Stem Cell Therapy
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Total 55006 results found since Jan 2013.
hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway
In this study, we aim to investigate the therapeutic efficacy and underlying mechanisms of human bone marrow-derived MSC (hMSC) on MHV-68-induced pneumonia. We found that intravenous administration of hMSCs significantly reduced lung damages, diminished inflammatory mediators and somehow inhibited MHV-68 replication. Furthermore, hMSCs treatment can regulate innate immune response and induce macrophage polarization from M1 to M2 phenotype, could significantly alter leukocyte infiltration and reduce pulmonary fibrosis. Our findings with co-culture system indicated that hMSCs effectively reduced the secretion of of inflammat...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Aiping Qin Xiao-Juan Wang Jijun Fu Ao Shen Xiaotao Huang Zhida Chen Huiting Wu Yu Jiang Qian Wang Fei Chen Andy Peng Xiang Xiyong Yu Source Type: research
SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes
CONCLUSION: Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.PMID:37705046 | DOI:10.1186/s13287-023-03485-3
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Juli Liu Shiyong Wu Yucheng Zhang Cheng Wang Sheng Liu Jun Wan Lei Yang Source Type: research
Development of hydrogel-based composite scaffolds containing eggshell particles for bone regeneration applications
This study describes the development and characterization of novel composite scaffolds, made of an alginate-chitosan hydrogel matrix containing eggshell (ES) particles, for bone tissue engineering applications. Scaffolds with ES particles, either untreated or treated with phosphoric acid to create a nanotextured particle surface, were compared to scaffolds without particles. Results indicate that the nanotexturing process exposed occluded ES proteins orthologous to those in human bone extracellular matrix. Scaffolds with ES or nanotextured ES (NTES) particles had a higher porosity (81 ± 4% and 89 ± 5%, respectively) than...
Source: Biomed Res - September 13, 2023 Category: Research Authors: Nicholas D Calvert Scott Proulx Alejandro Rodriguez-Navarro Tamer Ahmed Eric A Lehoux Maxwell T Hincke Isabelle Catelas Source Type: research
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research
Suprachoroidal spheroidal mesenchymal stem cell implantation in retinitis pigmentosa: clinical results of 6 months follow-up
CONCLUSION: Suprachoroidal implantation of MSCs in the form of spheroids as a stem cell therapy for RP patients with relatively good visual acuity has an improving effect on BCVA, VF and mfERG recordings during the 6-month follow-up period. Spheroidal MSCs with enhanced effects may be more successful in preventing apoptosis and improving retinal tissue healing in RP patients.PMID:37705097 | DOI:10.1186/s13287-023-03489-z
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Berna Özkan B üşra Yılmaz Tuğan Cansu Hem şinlioğlu G özde Sır Karakuş Özlem Şahin Erc üment Ovalı Source Type: research
Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury
CONCLUSION: MSC-EVs exhibit maximal lung accumulation when administered during heightened inflammation at 24 h after ALI induction. This lung tropism suggests that MSC-EVs may serve as a practical rescue treatment for acute inflammatory respiratory conditions.PMID:37705086 | DOI:10.1186/s13287-023-03472-8
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Alvin Tieu Duncan J Stewart Damian Chwastek Casey Lansdell Dylan Burger Manoj M Lalu Source Type: research
The spatiotemporal heterogeneity of the biophysical microenvironment during hematopoietic stem cell development: from embryo to adult
Stem Cell Res Ther. 2023 Sep 13;14(1):251. doi: 10.1186/s13287-023-03464-8.ABSTRACTHematopoietic stem cells (HSCs) with the ability to self-renew and differentiate are responsible for maintaining the supply of all types of blood cells. The complex and delicate microenvironment surrounding HSCs is called the HSC niche and can provide physical, chemical, and biological stimuli to regulate the survival, maintenance, proliferation, and differentiation of HSCs. Currently, the exploration of the biophysical regulation of HSCs remains in its infancy. There is evidence that HSCs are susceptible to biophysical stimuli, suggesting t...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Guolin Shi Pan Zhang Xi Zhang Jing Li Xinmin Zheng Jinxiao Yan Nu Zhang Hui Yang Source Type: research
Loss of Dip2b leads to abnormal neural differentiation from mESCs
CONCLUSIONS: Our results suggest that Dip2b plays an important role in neural differentiation, which will provide a valuable model for studying the exact mechanisms of Dip2b during neural differentiation.PMID:37705068 | DOI:10.1186/s13287-023-03482-6
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Mingze Yao Yuanqing Pan Tinglin Ren Caiting Yang Yu Lei Xiaoyu Xing Lei Zhang Xiaogang Cui Yaowu Zheng Li Xing Changxin Wu Source Type: research
Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts
Braz J Med Biol Res. 2023 Sep 8;56:e12546. doi: 10.1590/1414-431X2023e12546. eCollection 2023.ABSTRACTIntense stimulation of most living cells triggers the activation of immediate early genes, such as Fos and Jun families. These genes are important in cellular and biochemical processes, such as mitosis and cell death. The present study focused on determining the temporal expression pattern of Fos and Jun families in fibroblasts and neural stem cells of cerebellum, hippocampus, and subventricular zone (SVZ) of rats of different ages at 0, 0.5, 1, 3, and 6 h after stimulation with fibroblast growth factor (FGF)-2. In neonate...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: A C Mosini P C Mazzonetto M L Cali ó C Pompeu F H Massinhani T K E Nakamura J M Pires C S Silva M A Porcionatto L E Mello Source Type: research
Let the Guard Down: cAMP Activators Can Improve Immunotherapy in GBM
Cancer Immunol Res. 2023 Sep 12:OF1-OF2. doi: 10.1158/2326-6066.CIR-23-0667. Online ahead of print.ABSTRACTEnhancing T-cell infiltration into glioblastoma (GBM) tumors has proven challenging yet remains crucial for improving the efficacy of immunotherapy for patients with this deadly cancer. In this issue, Qin, Huang, Li, and colleagues find that inhibiting vasculature formation driven by cancer stem cells is a promising target to enhance immunotherapy in GBM. See related article by Qin et al. (2).PMID:37702792 | DOI:10.1158/2326-6066.CIR-23-0667
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Juyeun Lee Kristen E Kay Michael A Vogelbaum Justin D Lathia Source Type: research
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Brain Research - September 13, 2023 Category: Neurology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research
Development of hydrogel-based composite scaffolds containing eggshell particles for bone regeneration applications
This study describes the development and characterization of novel composite scaffolds, made of an alginate-chitosan hydrogel matrix containing eggshell (ES) particles, for bone tissue engineering applications. Scaffolds with ES particles, either untreated or treated with phosphoric acid to create a nanotextured particle surface, were compared to scaffolds without particles. Results indicate that the nanotexturing process exposed occluded ES proteins orthologous to those in human bone extracellular matrix. Scaffolds with ES or nanotextured ES (NTES) particles had a higher porosity (81 ± 4% and 89 ± 5%, respectively) than...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Nicholas D Calvert Scott Proulx Alejandro Rodriguez-Navarro Tamer Ahmed Eric A Lehoux Maxwell T Hincke Isabelle Catelas Source Type: research
Allogeneic stem cell transplant for multiple myeloma & amp; myelofibrosis with split-dose busulfan, fludarabine & amp; cyclophosphamide
Leuk Res Rep. 2023 Aug 26;20:100388. doi: 10.1016/j.lrr.2023.100388. eCollection 2023.ABSTRACTAllogeneic stem cell transplant can have high morbidity and mortality in patients with myelofibrosis (MF) and multiple myeloma (MM). This phase 2 study used a novel myeloablative regimen of split-dose busulfan, fludarabine, and then post-transplant cyclophosphamide. Four patients with MF and 2 with MM were enrolled. At 1 year, non-relapse mortality was 33.3%, and overall survival was 50%. Incidence of acute and chronic GVHD was 33.3% and 16.7%, respectively. Those surviving beyond 1 year (MF = 1, MM = 2) had durable remissions wit...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Andrew D Trunk Sagar S Patel Josef T Prchal Douglas W Sborov Axel R Zander Catherine J Lee Source Type: research
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Brain Research Bulletin - September 13, 2023 Category: Neurology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research
TR β Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
Endocrinology. 2023 Sep 13:bqad135. doi: 10.1210/endocr/bqad135. Online ahead of print.ABSTRACTThyroid hormone receptor beta (TRβ) is a recognized tumor suppressor in numerous solid cancers. The molecular signaling of TRβ has been elucidated in several cancer types through re-expression models. Remarkably, the potential impact of selective activation of endogenous TRβ on tumor progression remains largely unexplored. We used cell-based and in vivo assays to evaluate the effects of the TRβ agonist Sobetirome (GC-1) on a particularly aggressive and dedifferentiated cancer, anaplastic thyroid cancer (ATC). Here we report t...
Source: Endocrinology - September 13, 2023 Category: Endocrinology Authors: Noelle E Gillis Lauren M Cozzens Emily R Wilson Noah M Smith Jennifer A Tomczak Eric L Bolf Frances E Carr Source Type: research
