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Therapy: Stem Cell Therapy
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Total 55006 results found since Jan 2013.
Haploidentical Natural Killer Cell Therapy as an Adjunct to Stem Cell Transplantation for Treatment of Refractory Acute Myeloid Leukemia
Cell Transplant. 2023 Jan-Dec;32:9636897231198178. doi: 10.1177/09636897231198178.ABSTRACTRefractory acute myeloid leukemia (AML), defined as failure of two cycles of induction therapy at diagnosis or of one cycle at relapse, represents a subgroup with poor outcomes. Haploidentical natural killer cell (NK) therapy is a strategy that is being explored in refractory malignancies. Historically, at our center, patients with refractory AML have been treated with cytoreductive therapy (fludarabine + cytosine + granulocyte colony-stimulating factor ± idarubicin or mitoxantrone + etoposide) followed by 1-week rest and then reduce...
Source: Cell Transplantation - September 14, 2023 Category: Cytology Authors: Uday Kulkarni Arun Kumar Arunachalam Hamenth Kumar Palani Reeshma Radhakrishnan Nair Nithya Balasundaram Arvind Venkatraman Anu Korula Sushil Selvarajan Sharon Lionel Poonkuzhali Balasubramanian Madhavi Maddali Aby Abraham Biju George Vikram Mathews Source Type: research
Illuminating the path to shoot meristem regeneration: Molecular insights into reprogramming cells into stem cells
Curr Opin Plant Biol. 2023 Sep 13:102452. doi: 10.1016/j.pbi.2023.102452. Online ahead of print.ABSTRACTPlant cells possess the ability to dedifferentiate and reprogram into stem cell-like populations, enabling the regeneration of new organs. However, the maintenance of stem cells relies on specialized microenvironments composed of distinct cell populations with specific functions. Consequently, the regeneration process necessitates the orchestrated regulation of multiple pathways across diverse cellular populations. One crucial pathway involves the transcription factor WUSCHEL HOMEOBOX 5 (WOX5), which plays a pivotal role...
Source: Current Opinion in Plant Biology - September 14, 2023 Category: Biology Authors: Yetkin Çaka Ince Keiko Sugimoto Source Type: research
Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2
CONCLUSION: Exosomal NFIC silencing-loaded ADSC sheet modulates miR-204-3p/HIPK2 axis to suppress HG-induced HUVEC proliferation, migration, and angiogenesis, providing a stem cell-based treatment strategy for DFU.PMID:37710299 | DOI:10.1186/s13018-023-04165-x
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Huimin Huang Wufei Zhu Zongwei Huang Dengze Zhao Lu Cao Xian Gao Source Type: research
The stomatal fates: Understanding initiation and enforcement of stomatal cell fate transitions
Curr Opin Plant Biol. 2023 Sep 12:102449. doi: 10.1016/j.pbi.2023.102449. Online ahead of print.ABSTRACTIn the stomatal lineage, repeated arcs of initiation, stem-cell proliferation, and terminal cell fate commitment are displayed on the surface of aerial organs. Over the past two decades, the core transcription and signaling elements that guide cell divisions, patterning, and fate transitions were defined. Here we highlight recent work that extends the core using a variety of cutting-edge techniques in different plant species. New work has discovered transcriptional circuits that initiate and reinforce stomatal fate trans...
Source: Current Opinion in Plant Biology - September 14, 2023 Category: Biology Authors: Margot E Smit Dominique C Bergmann Source Type: research
Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient
In this study, we successfully generated two induced pluripotent stem cell (iPSC) lines from an infant with non-heritable RB. Both cell clones exhibited typical iPSC characteristics with normal karyotypes, consistent pluripotency markers expression and the capability of trilineage differentiation.PMID:37708614 | DOI:10.1016/j.scr.2023.103200
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Ping Xu Fuying Guo Wei Xiao Yuan Wang Ke Ye Yuxiang Mao Xiufeng Zhong Source Type: research
Generation of a TRPV1 knockout human pluripotent stem cell line (WAe009-A-U) using CRISPR/Cas9
Stem Cell Res. 2023 Sep 9;72:103202. doi: 10.1016/j.scr.2023.103202. Online ahead of print.ABSTRACTThe transient receptor potential vanilloid subfamily 1 (TRPV1) is a polymodal nociceptor that is highly expressed in sensory nerves. Activation of TRPV1 receptors excites primary afferent nociceptors by opening cation channels, allowing the influx of Na+ and Ca2+ ions into the cytoplasm. Here, a TRPV1 knockout human embryonic stem cell line was generated using the CRISPR/Cas9 genome-editing technology to further study the function of TRPV1. The cell line confirmed with normal pluripotency and karyotype.PMID:37708613 | DOI:10....
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Yuhong Cao Ling Tang Jun Su Hao Wang Ping Liang Kuang Rong Tingyu Gong Source Type: research
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Cancer Metastasis Rev. 2023 Sep 14. doi: 10.1007/s10555-023-10138-7. Online ahead of print.ABSTRACTResistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially the genetic mutation behind the therapeutic resistance. However, non-mutational mechanisms, such as epigenetic modifications, and TME alteration, which is mainly driven by cancer cell plasticity, are also involved in therapeutic resistance. The concept of plasticity mainly relies on the conversion of non-cancer stem cells (CSCs) to CSCs or epithelial-to-mesenchymal transition via d...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Priya Mondal Syed Musthapa Meeran Source Type: research
An early neoplasia index (ENI10), based on molecular identity of CD10 cells and associated stemness biomarkers, is a predictor of patient outcome in many cancers
Cancer Res Commun. 2023 Sep 14. doi: 10.1158/2767-9764.CRC-23-0196. Online ahead of print.ABSTRACTAn accurate estimate of patient survival at diagnosis is critical to plan efficient therapeutic options. A simple and multi-application tool is needed to move forward the precision medicine era. Taking advantage of the broad and high CD10 expression in stem and cancers cells, we evaluated the molecular identity of aggressive cancer cells. We used epithelial primary cells and developed a breast cancer stem cells-based progressive model. The superiority of the early-transformed isolated molecular index was evaluated by large-sca...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Boris Guyot Flora Cl ément Youenn Drouet Xenia Schmidt Sylvain Lefort Emmanuel Delay Isabelle Treilleux Jean-Philippe Foy Sandrine Jeanpierre Emilie Thomas Janice Kielbassa Laurie Tonon Helen He Zhu Pierre Saintigny Wei-Qiang Gao Arnaud de la Fouchardier Source Type: research
The role of plasma-induced surface chemistry on polycaprolactone nanofibers to direct chondrogenic differentiation of human mesenchymal stem cells
This study investigates how different surface properties induced by either coating deposition or biomolecules immobilization onto nanofibers (NFs) could affect BMSCs chondro-inductive behavior. Accordingly, electrospun poly(ε-caprolactone) (PCL) NFs were exposed to two surface modification strategies based on medium-pressure plasma technology. The first strategy is plasma polymerization, in which cyclopropylamine (CPA) or acrylic acid (AcAc) monomers were plasma polymerized to obtain amine- or carboxylic acid-rich NFs, respectively. The second strategy uses a combination of CPA plasma polymerization and a post-chemical te...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Mahtab Asadian Clarissa Tomasina Yuliia Onyshchenko Ke Vin Chan Mohammad Norouzi Jip Zonderland Sandra Camarero-Espinosa Rino Morent Nathalie De Geyter Lorenzo Moroni Source Type: research
Treg-targeted IL-2/anti-IL-2 complex controls graft- < em > versus < /em > -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2022.282653. Online ahead of print.ABSTRACTModulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Allan Thiolat Caroline Pilon Pamela Caudana Audrey Moatti Nhu Hanh To Christine Sedlik Mathieu Leclerc S ébastien Maury Eliane Piaggio Jos é L Cohen Source Type: research
Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research
Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Annu Rev Genet. 2023 Sep 14. doi: 10.1146/annurev-genet-022123-090319. Online ahead of print.ABSTRACTMany human phenotypes are impossible to recapitulate in model organisms or immortalized human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease mechanisms in a variety of differentiated cell types while circumventing ethical and practical issues associated with finite tissue sources and postmortem states. Here, we discuss the broad utility of iPSCs in genetic medicine and describe how they are being used to study musculoskeletal, pulmonary, neurologic, and cardiac phenotypes. We summarize the p...
Source: Annual Review of Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Ayodeji Adegunsoye Natalia M Gonzales Yoav Gilad Source Type: research
Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage
Aging (Albany NY). 2023 Sep 14;15. doi: 10.18632/aging.205026. Online ahead of print.ABSTRACTPathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced ...
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Dennis Jine-Yuan Hsieh Bruce Chi-Kang Tsai Parthasarathi Barik Marthandam Asokan Shibu Chia-Hua Kuo Wei-Wen Kuo Pi-Yu Lin Cheng-Yen Shih Shinn-Zong Lin Tsung-Jung Ho Chih-Yang Huang Source Type: research
Anti-inflammatory protein TSG-6 secreted by BMSCs attenuates silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome signaling in macrophages
In this study, we focused on the early phase of silica-induced lung injury to investigate the therapeutic effect of BMSCs. Our findings demonstrated that BMSCs attenuated silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome pathways in lung macrophages. To further understand the mechanisms involved, we utilized RNA sequencing to analyze the transcriptomes of BMSCs co-cultured with silica-stimulated bone marrow-derived macrophages (BMDMs). The results clued tumor necrosis factor-stimulated gene 6 (TSG-6) might be a potentially key paracrine secretion factor released from BMSCs, which exerts a protect...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Wenyao Su Qiying Nong Jie Wu Ruihong Fan Yuanting Liang Anyi Hu Zhongxiang Gao Weihui Liang Qifei Deng Hailan Wang Lihua Xia Yongshun Huang Yiru Qin Na Zhao Source Type: research
