Filtered By:
Therapy: Stem Cell Therapy
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 55006 results found since Jan 2013.
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Bladder cancer course, four genetic high-risk variants, and histopathological findings
This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. The distribution of the 4 SNPs does not vary significantly between cases and controls in the entire study group and in the 3 local subgroups, including two former highly industrialized areas and a region without such history. Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do ...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Thura Kadhum Silvia Selinski Meinolf Blaszkewicz J örg Reinders Emanuel Roth Frank Volkert Daniel Ovsiannikov Oliver Moormann Holger Gerullis Dimitri Barski Thomas Otto Svetlana H öhne Jan G Hengstler Klaus Golka Source Type: research
The two-step approach to allogeneic hematopoietic stem cell transplantation
Front Immunol. 2023 Sep 1;14:1237782. doi: 10.3389/fimmu.2023.1237782. eCollection 2023.ABSTRACTAllogeneic hematopoietic stem cell transplantation (HSCT) provides the only potentially curative option for multiple hematological conditions. However, allogeneic HSCT outcomes rely on an optimal balance of effective immune recovery, minimal graft-versus-host disease (GVHD), and lasting control of disease. The quest to attain this balance has proven challenging over the past few decades. The two-step approach to HSCT was conceptualized and pioneered at Thomas Jefferson University in 2005 and remains the main platform for allogra...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Sikemi Ibikunle Dolores Grosso Usama Gergis Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Autoimmune responses and therapeutic interventions for systemic lupus erythematosus: a comprehensive review
Endocr Metab Immune Disord Drug Targets. 2023 Sep 15. doi: 10.2174/1871530323666230915112642. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multiple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better understanding of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of infla...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 18, 2023 Category: Endocrinology Authors: Surya Prakash Pandey Rakesh Bhaskar Sung Soon Han Kannan Badri Narayanan Source Type: research
The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration
Zool Res. 2023 Sep 18;44(5):981-992. doi: 10.24272/j.issn.2095-8137.2023.044.ABSTRACTPlanarians represent the most primitive bilateral triploblastic animals. Most planarian species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration of their cephalic ganglion after complete excision. Given their robust whole-body regeneration capacity, planarians have been model organisms in regenerative research for more than 240 years. Advancements in research tools and techniques have progressively elucidated the mechanisms underlying planarian regeneration. Accurate cell-cell communication is recognized as a...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jia-Jia Chen Kai Lei Source Type: research
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
Res Sq. 2023 Sep 8:rs.3.rs-3266720. doi: 10.21203/rs.3.rs-3266720/v1. Preprint.ABSTRACTThe alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approv...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hung-Ying Kao Chun-Peng Pai Han Wang Neel Agarwal Joshua Adams Zhenghao Liu Darcie Seachrist Ruth Keri William Schiemann Source Type: research
Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury
Res Sq. 2023 Sep 5:rs.3.rs-3242570. doi: 10.21203/rs.3.rs-3242570/v1. Preprint.ABSTRACTEfficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc expressing human neural stem cells (LMNSC008) demonstrate an inherent tropism to injury sites after intranasal (IN) administration. We hypothesize that IN delivered LMNSC008 cells migrate to primary and secondary injury sites and modulate biomarkers associated with neuroprotection and tissue regeneration. To test this, immunocompetent adult female rats received a c...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Mari Amirbekyan Jeffrey P Cheng Vikram Adhikarla Eleni H Moschonas Corina O Bondi Russell C Rockne Anthony E Kline Margarita Gutova Source Type: research
Using a Modified Delphi Panel to Estimate Health Service Utilization for Patients with Advanced and Non-Advanced Systemic Light Chain Amyloidosis
CONCLUSION: Experts estimated advanced patients, who would not be good candidates for HSCT, would have high rates of hospitalization (traditionally the most expensive type of healthcare utilization) and other health service use. The development of new treatment options that can facilitate organ recovery and improve function may lead to decreased utilization.PMID:37719133 | PMC:PMC10503521 | DOI:10.2147/CEOR.S412079
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Morie Gertz Rafat Abonour Sarah N Gibbs Muriel Finkel Heather Landau Suzanne Lentzsch Grace Lin Anuj Mahindra Tiffany Quock Cara Rosenbaum Michael Rosenzweig Surbhi Sidana Sascha A Tuchman Ronald Witteles Irina Yermilov Michael S Broder Source Type: research
Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities
J Oral Biol Craniofac Res. 2023 Nov-Dec;13(6):693-703. doi: 10.1016/j.jobcr.2023.08.009. Epub 2023 Sep 12.ABSTRACTSalivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e. ECM) becomes dysregulated, leading to alterations in matrix composition which disrupt tissue architecture/structure, alter cell activity, and negatively impact gland function. Matrix metalloproteinases (MMPs) are a large and diverse family of metalloendopeptidases which play a ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Milos Marinkovic Olivia N Tran Hanzhou Wang Parveez Abdul-Azees David D Dean Xiao-Dong Chen Chih-Ko Yeh Source Type: research
