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Therapy: Immunotherapy
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Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Technology in Cancer Research and Treatment - September 20, 2023 Category: Cancer & Oncology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Clinical characteristics and treatment efficacy of immune checkpoint inhibitors (ICIs) in patients with ICIs-induced Adrenal insufficiency
CONCLUSIONS: ICI-induced AI is a rare irAE, and close monitoring of cortisol levels is important. Patients diagnosed with AI after receiving immunotherapy seem to have a favorable outcome.PMID:37729740 | DOI:10.1016/j.tranon.2023.101787
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jing Xiang Xueni Liu Yue Hao Yanyan Zhu Minhua Wu Jian Lou Yonghui Wang Chunwei Xu Yanru Xie Jianhui Huang Source Type: research
Aminated yeast β-D-glucan for macrophage-targeted delivery of CpG oligodeoxynucleotides and synergistically enhanced cancer immunotherapy
Int J Biol Macromol. 2023 Sep 18:126998. doi: 10.1016/j.ijbiomac.2023.126998. Online ahead of print.ABSTRACTCpG oligodeoxynucleotides (CpG ODNs) activate immune system and show strong potential in cancer immunotherapy. However, therapeutic efficacy of CpG ODNs is hampered due to rapid nuclease degradation and insufficient cellular uptake. Delivery of CpG ODNs into antigen presenting cells (APCs) is vital to enhance their therapeutic efficacy. Herein, we developed a super-convenient yet efficient strategy for macrophage-targeted delivery of CpG ODNs and synergistically enhanced cancer immunotherapy. Aminated yeast β-D-gluc...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Huijie Zhang Zhiqing Wang Shuo Wang Jiawen Zhang Lipeng Qiu Jinghua Chen Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Phenotypic changes in mast cells during allergy immunotherapy
Arerugi. 2023;72(8):1026-1031. doi: 10.15036/arerugi.72.1026.NO ABSTRACTPMID:37730345 | DOI:10.15036/arerugi.72.1026
Source: Arerugi - September 20, 2023 Category: Allergy & Immunology Authors: Haruki Sasa Hitoshi Ogata Yosuke Kurashima Source Type: research
Guide of allergen immunotherapy
Arerugi. 2023;72(8):1007-1010. doi: 10.15036/arerugi.72.1007.NO ABSTRACTPMID:37730341 | DOI:10.15036/arerugi.72.1007
Source: Arerugi - September 20, 2023 Category: Allergy & Immunology Authors: Minoru Gotoh Source Type: research
Clinical characteristics and treatment efficacy of immune checkpoint inhibitors (ICIs) in patients with ICIs-induced Adrenal insufficiency
CONCLUSIONS: ICI-induced AI is a rare irAE, and close monitoring of cortisol levels is important. Patients diagnosed with AI after receiving immunotherapy seem to have a favorable outcome.PMID:37729740 | DOI:10.1016/j.tranon.2023.101787
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jing Xiang Xueni Liu Yue Hao Yanyan Zhu Minhua Wu Jian Lou Yonghui Wang Chunwei Xu Yanru Xie Jianhui Huang Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Characterization of tumor microenvironment and sensitive chemotherapy drugs based on cuproptosis-related signatures in renal cell carcinoma
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205043. Online ahead of print.ABSTRACTCuproptosis is a novel type of copper-induced cell death and is considered as a new therapeutic target for many cancers. Distant metastases occur in about 40% of patients with advanced renal cell carcinoma (RCC), with a poor 5-year prognosis of about 10%. Through a series of comprehensive analyses, four differentially expressed cuproptosis-related lncRNAs (DECRLs) were identified as candidate biomarkers for RCC. The risk model constructed by using these four DECRLs can better predict the prognosis of patients with RCC, which is det...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Jiefu Tang Fan Yao Zhiyong Yao Xiao-Liang Xing Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Targeted therapy and immunotherapy for orbital and periorbital tumors: a major review
This article will focus on recent updates in the application of available targeted and immunotherapy for managing orbital and periorbital tumors and tumor-like conditions, which include cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, cutaneous melanoma, Merkel cell carcinoma, sebaceous gland carcinoma, solitary fibrous tumor, dermatofibrosarcoma protuberans, orbital meningioma, neurofibromatosis, Langerhans cell histiocytosis, ocular adnexal lymphoma, orbital lymphatic malformation, and adenoid cystic carcinoma.PMID:37728602 | DOI:10.1080/01676830.2023.2256848
Source: Orbit - September 20, 2023 Category: Opthalmology Authors: Emmanuel Lee Boniao Richard C Allen Gangadhara Sundar Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
