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Drug: Insulin
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Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: American Journal of Physiology. Cell Physiology - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
Managing diabetic complications with alternative therapeutic strategies
Curr Diabetes Rev. 2023 Sep 7. doi: 10.2174/1573399820666230907112430. Online ahead of print.ABSTRACTDiabetes is a chronic metabolic disease affecting millions worldwide. It is characterized by a lack of insulin production or impaired insulin function, leading to elevated blood glucose levels. Conventional treatment methods for diabetes management typically include lifestyle changes and medications. However, alternative therapies have gained attention in recent years, including traditional medicine containing bioactive compounds, supplements like vitamin D and Omega-3 fatty acids, aromatherapy, and homeopathy. Diabetic com...
Source: Current Diabetes Reviews - September 11, 2023 Category: Endocrinology Authors: Shobhit Prakash Srivastava Pawan Upadhyay Shibu Das Neha Tiwari Sudhanshu Mishra Shivendra Mani Tripathi Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: American Journal of Physiology. Cell Physiology - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | DOI:10.1186/s12981-023-00564-6
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Hyperglycemia-related anxiety during competition in an elite athlete with type 1 diabetes: a case report
CONCLUSION: Hyperglycemia-related anxiety leads to modified therapeutic and lifestyle regimens on competition day. Tailored treatment programs are needed for elite athletes with T1D and hyperglycemia-related anxiety.PMID:37689238 | DOI:10.1016/j.diabet.2023.101476
Source: Diabetes and Metabolism - September 9, 2023 Category: Endocrinology Authors: Alexandra Katz Aidan Shulkin Meryem K Talbo Asmaa Housni Jane Yardley Anne-Sophie Brazeau R émi Rabasa-Lhoret Source Type: research
