Filtered By:
Drug: Insulin
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 38796 results found since Jan 2013.
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | PMC:PMC10492310 | DOI:10.1186/s12981-023-00564-6
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research
Hyperglycemia-related anxiety during competition in an elite athlete with type 1 diabetes: a case report
CONCLUSION: Hyperglycemia-related anxiety leads to modified therapeutic and lifestyle regimens on competition day. Tailored treatment programs are needed for elite athletes with T1D and hyperglycemia-related anxiety.PMID:37689238 | DOI:10.1016/j.diabet.2023.101476
Source: Diabetes and Metabolism - September 9, 2023 Category: Endocrinology Authors: Alexandra Katz Aidan Shulkin Meryem K Talbo Asmaa Housni Jane Yardley Anne-Sophie Brazeau R émi Rabasa-Lhoret Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Hyperglycemia-related anxiety during competition in an elite athlete with type 1 diabetes: a case report
CONCLUSION: Hyperglycemia-related anxiety leads to modified therapeutic and lifestyle regimens on competition day. Tailored treatment programs are needed for elite athletes with T1D and hyperglycemia-related anxiety.PMID:37689238 | DOI:10.1016/j.diabet.2023.101476
Source: Diabetes and Metabolism - September 9, 2023 Category: Endocrinology Authors: Alexandra Katz Aidan Shulkin Meryem K Talbo Asmaa Housni Jane Yardley Anne-Sophie Brazeau R émi Rabasa-Lhoret Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Probing the molecular interactions between cholinium-based ionic liquids and insulin aspart: A combined computational and experimental study
Int J Biol Macromol. 2023 Sep 7:126665. doi: 10.1016/j.ijbiomac.2023.126665. Online ahead of print.ABSTRACTDespite extensive studies revealing the potential of cholinium-based ionic liquids (ILs) in protein stabilization, the nature of interaction between ILs' constituents and protein residues is not well understood. In this work, we used a combined computational and experimental approach to investigate the structural stability of a peptide hormone, insulin aspart (IA), in ILs containing a choline cation [Ch]+ and either dihydrogen phosphate ([Dhp]-) or acetate ([Ace]-) as anions. Although IA remained stable in both 1 M [C...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Vidya Sundaram Ramakrishnan Nagasundara Ramanan Manikandan Selvaraj Nafees Ahemad R Vijayaraghavan Douglas R MacFarlane Chien Wei Ooi Source Type: research
Hyperglycemia-related anxiety during competition in an elite athlete with type 1 diabetes: a case report
CONCLUSION: Hyperglycemia-related anxiety leads to modified therapeutic and lifestyle regimens on competition day. Tailored treatment programs are needed for elite athletes with T1D and hyperglycemia-related anxiety.PMID:37689238 | DOI:10.1016/j.diabet.2023.101476
Source: Diabetes and Metabolism - September 9, 2023 Category: Endocrinology Authors: Alexandra Katz Aidan Shulkin Meryem K Talbo Asmaa Housni Jane Yardley Anne-Sophie Brazeau R émi Rabasa-Lhoret Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
