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Association of < em > CYP3A5*3, CYP3A4*18 & amp; CYP2B6*6 < /em > polymorphisms with imatinib treatment outcome in Azerbaijani chronic myeloid leukaemia patients
CONCLUSIONS: Our results demonstrated that CYP3A4*18 was significantly associated with IM treatment response in patients with CML in Azerbaijan, whereas rather common CYP3A5*3 was identified to have no such association.PMID:37706370 | DOI:10.4103/ijmr.ijmr_1103_22
Source: The Indian Journal of Medical Research - September 14, 2023 Category: Biomedical Science Authors: Chingiz Asadov Nigar Karimova Aypara Hasanova Bayram Bayramov Aytan Shirinova Zohra Alimirzoyeva Source Type: research
Prognostic Markers in the Era of Targeted Therapies
Acta Haematol. 2023 Sep 13. doi: 10.1159/000533704. Online ahead of print.ABSTRACTBackground Small molecules targeting Bruton's tyrosine kinase (BTK) and B-cell lymphoma-2 have become the standard of care for the treatment of chronic lymphocytic leukemia (CLL), replacing chemoimmunotherapy (CIT) in most clinical settings. Ongoing trials explore targeted combinations and minimal residual disease-driven treatment cessation. These dramatic shifts in the current and upcoming treatment landscape of CLL raise the need to reevaluate existing prognostic markers and develop novel ones. Summary This review examines prognostic marker...
Source: Acta Haematologica - September 13, 2023 Category: Hematology Authors: Sorang Kang Inhye E Ahn Source Type: research
Outcomes of Children Discharged Prior to Absolute Neutrophil Count Recovery After Admission for Febrile Neutropenia
J Pediatr Hematol Oncol. 2023 Sep 13. doi: 10.1097/MPH.0000000000002757. Online ahead of print.ABSTRACTFebrile neutropenia (FN) management in pediatric oncology patients traditionally necessitates inpatient admission until evidence of bone marrow recovery. Discharge before count recovery may be a way to safely reduce the length of hospitalizations for select patients. A chart review was conducted of patients admitted for FN at one tertiary care children's hospital, where the standard is to discharge well-appearing patients after 48 hours of negative cultures if afebrile for at least 24 hours, irrespective of absolute neutr...
Source: Ann Oncol - September 13, 2023 Category: Cancer & Oncology Authors: Sarah Peters Mark Adler Jenna Rossoff Source Type: research
Correction to: T cell functions and organ infiltration by leukemic T cells require cortactin
J Leukoc Biol. 2023 Sep 13:qiad105. doi: 10.1093/jleuko/qiad105. Online ahead of print.NO ABSTRACTPMID:37703329 | DOI:10.1093/jleuko/qiad105
Source: Journal of Leukocyte Biology - September 13, 2023 Category: Hematology Source Type: research
Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML
CONCLUSIONS: We developed a nanoscale combination drug formulation that exploits ectopic expression of MERTK tyrosine kinase and dependency on BCL-2 family proteins for leukemia cell survival in pediatric AML and infant ALL cells. We demonstrate ratiometric drug delivery and synergistic cell killing in AML, a result achieved by a systematic, generalizable approach of combination drug screening and nanoscale formulation that may be extended to other drug pairs or diseases in the future.PMID:37704893 | DOI:10.1007/s11095-023-03596-9
Source: Cell Research - September 13, 2023 Category: Cytology Authors: James M Kelvin Juhi Jain Aashis Thapa Min Qui Lacey A Birnbaum Samuel G Moore Henry Zecca Ryan J Summers Jeffrey M Switchenko Emma Costanza Biaggio Uricoli Xiaodong Wang Nathan T Jui Haian Fu Yuhong Du Deborah DeRyckere Douglas K Graham Erik C Dreaden Source Type: research
Prognostic Markers in the Era of Targeted Therapies
Acta Haematol. 2023 Sep 13. doi: 10.1159/000533704. Online ahead of print.ABSTRACTBackground Small molecules targeting Bruton's tyrosine kinase (BTK) and B-cell lymphoma-2 have become the standard of care for the treatment of chronic lymphocytic leukemia (CLL), replacing chemoimmunotherapy (CIT) in most clinical settings. Ongoing trials explore targeted combinations and minimal residual disease-driven treatment cessation. These dramatic shifts in the current and upcoming treatment landscape of CLL raise the need to reevaluate existing prognostic markers and develop novel ones. Summary This review examines prognostic marker...
Source: Acta Haematologica - September 13, 2023 Category: Hematology Authors: Sorang Kang Inhye E Ahn Source Type: research
Leukemic-phase mucosa-associated lymphoid tissue lymphoma
Int J Hematol. 2023 Sep 12. doi: 10.1007/s12185-023-03654-3. Online ahead of print.ABSTRACTA 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagno...
Source: International Journal of Hematology - September 12, 2023 Category: Hematology Authors: Takayuki Yotsuyanagi Naoto Tomita Yusuke Saiki Akiko Uchida Yu Uemura Yoshinori Suzuki Tsuneaki Hirakawa Masayuki Kato Naoya Nakamura Ayako Arai Source Type: research
Glycan node profiling of soluble and membrane glycoproteins in whole cell lysates
Anal Biochem. 2023 Sep 10:115317. doi: 10.1016/j.ab.2023.115317. Online ahead of print.ABSTRACTGlycan node analysis (GNA) is a molecularly bottom-up glycomics technique based on the relative quantification of glycan linkage-specific monosaccharide units ("glycan nodes"). It was originally applied to blood plasma/serum, where it detected and predicted progression, reoccurrence, and survival in different types of cancer. Here, we have adapted this technology to previously inaccessible membrane glycoproteins from cultured cells. The approach is facilitated by methanol/chloroform precipitation of cell lysates and a "liquid pha...
Source: Analytical Biochemistry - September 12, 2023 Category: Biochemistry Authors: Jes ús S Aguilar Díaz de León Jorvani Cruz Villarreal Erandi P Kapuruge Chad R Borges Source Type: research
Leukemic-phase mucosa-associated lymphoid tissue lymphoma
Int J Hematol. 2023 Sep 12. doi: 10.1007/s12185-023-03654-3. Online ahead of print.ABSTRACTA 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagno...
Source: International Journal of Hematology - September 12, 2023 Category: Hematology Authors: Takayuki Yotsuyanagi Naoto Tomita Yusuke Saiki Akiko Uchida Yu Uemura Yoshinori Suzuki Tsuneaki Hirakawa Masayuki Kato Naoya Nakamura Ayako Arai Source Type: research
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | PMC:PMC10497350 | DOI:10.3346/jkms.2023.38.e281
Source: J Korean Med Sci - September 12, 2023 Category: General Medicine Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
Final report of TKI discontinuation trial with dasatinib for the second attempt of treatment-free remission after failing the first attempt with imatinib: Treatment-free Remission Accomplished by Dasatinib (TRAD) study
Br J Haematol. 2023 Sep 11. doi: 10.1111/bjh.19058. Online ahead of print.ABSTRACTMultiple studies have reported a significant treatment-free remission (TFR) rate of 50%-60% in patients with chronic myeloid leukaemia (CML) who discontinue tyrosine kinase inhibitor (TKI) therapy. However, the remaining half of these patients still require re-initiation of TKI therapy for leukaemia control. It remains unclear if TKI drugs should be switched for re-therapy in patients who failed the first TFR (TFR1) attempt. Our study attempted to determine whether dasatinib therapy after TFR1 failure post-imatinib discontinuation could impro...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Maria Agustina Perusini Igor Novitzky-Basso Eshetu G Atenafu Donna Forrest Isabelle Bence-Bruckler Lynn Savoie Mary-Margaret Keating Lambert Busque Robert Delage Anargyros Xenocostas Elena Liew Pierre Laneuville Kristjan Paulson Tracy Stockley Jeffrey H L Source Type: research
Glycan node profiling of soluble and membrane glycoproteins in whole cell lysates
Anal Biochem. 2023 Sep 10:115317. doi: 10.1016/j.ab.2023.115317. Online ahead of print.ABSTRACTGlycan node analysis (GNA) is a molecularly bottom-up glycomics technique based on the relative quantification of glycan linkage-specific monosaccharide units ("glycan nodes"). It was originally applied to blood plasma/serum, where it detected and predicted progression, reoccurrence, and survival in different types of cancer. Here, we have adapted this technology to previously inaccessible membrane glycoproteins from cultured cells. The approach is facilitated by methanol/chloroform precipitation of cell lysates and a "liquid pha...
Source: Analytical Biochemistry - September 12, 2023 Category: Biochemistry Authors: Jes ús S Aguilar Díaz de León Jorvani Cruz Villarreal Erandi P Kapuruge Chad R Borges Source Type: research
Unraveling the role of ZNF506 as a human PBS-pro-targeting protein for ERVP repression
Nucleic Acids Res. 2023 Sep 11:gkad731. doi: 10.1093/nar/gkad731. Online ahead of print.ABSTRACTKrüppel-associated box zinc finger proteins (KZFPs) function as a defense mechanism to maintain the genome stability of higher vertebrates by regulating the transcriptional activities of transposable elements (TEs). While previous studies have characterized ZFP809 as responsible for binding and repressing ERVs containing a proline tRNA primer-binding site (PBS-Pro) in mice, comparable KZFPs have not been identified in humans yet. Here, we identified ZNF506 as a PBS-Pro-binding protein in humans, which functions as a transcripti...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Qian Wu Lu Fang Yixuan Wang Peng Yang Source Type: research
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | PMC:PMC10497350 | DOI:10.3346/jkms.2023.38.e281
Source: J Korean Med Sci - September 12, 2023 Category: General Medicine Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
