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Cancer: Leukemia
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A commentary on the optimal red blood cell transfusion threshold in acute leukemia patients
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.594. Online ahead of print.NO ABSTRACTPMID:37677098 | DOI:10.2450/BloodTransfus.594
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Akua Asante Phuong-Lan Nguyen Neil Blumberg Source Type: research
LIF signaling regulates outer radial glial to interneuron fate during human cortical development
Cell Stem Cell. 2023 Aug 29:S1934-5909(23)00292-8. doi: 10.1016/j.stem.2023.08.009. Online ahead of print.ABSTRACTRadial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia. However, the mechanisms regulating oRG differentiation are unclear. oRG cells express leukemia-inhibitory factor (LIF) receptors during neurogenesis, and consistent with a role in stem cell self-renewal, LIF perturbation impacts oRG proliferation in cortical tissue and organoids. Surprisingly, LIF treatment also increases t...
Source: Cell Stem Cell - September 6, 2023 Category: Stem Cells Authors: Madeline G Andrews Clara Siebert Li Wang Matthew L White Jayden Ross Raul Morales Megan Donnay Gradi Bamfonga Tanzila Mukhtar Arpana Arjun McKinney Kaila Gemenes Shaohui Wang Qiuli Bi Elizabeth E Crouch Neelroop Parikshak Georgia Panagiotakos Eric Huang A Source Type: research
A case of Hodgkin lymphoma-type Richter syndrome presenting as small-intestinal perforation
Int J Hematol. 2023 Sep 6. doi: 10.1007/s12185-023-03655-2. Online ahead of print.ABSTRACTHodgkin lymphoma type of Richter syndrome (HL-type RS) is a rare disease that arises in patients with chronic lymphocytic leukemia (CLL). HL-type RS lesions can manifest in various sites and are often accompanied by related symptoms. This is the first case report to describe diagnosis of HL-type RS after emergency surgery for gastrointestinal perforation caused by the development of a HL-type RS lesion. A 47-year-old man diagnosed with CLL three years prior began treatment with ibrutinib due to worsening anemia and splenomegaly two mo...
Source: International Journal of Hematology - September 6, 2023 Category: Hematology Authors: Kosuke Miki Reiki Ogasawara Shunsuke Sugimura Junichi Sugita Rintaro Nozu Keisuke Kojima Daisuke Hidaka Ai Shimizu Kohei Okada Naoki Kobayashi Masahiro Ogasawara Masahiro Imamura Yoshihiro Matsuno Shuichi Ota Source Type: research
Oncogenic viral DNA related to human breast cancer found on cattle milk and meat
Comp Immunol Microbiol Infect Dis. 2023 Aug 27;101:102053. doi: 10.1016/j.cimid.2023.102053. Online ahead of print.ABSTRACTBovine leukemia virus (BLV) is a major cause of lymphoma in cattle and has been recently correlated to breast cancer in humans. How and whether BLV might reach humans remains unknown but it could be through cattle-derived milk and meat. Here our aim was to investigate whether BLV DNA could be found in fresh milk and raw meat destined to human consumption and whether anti-BLV antibodies could be detected in human blood at the same geographical region. Milk (n = 36) and meat (n = 54) samples were collect...
Source: Comparative immunology, microbiology and infectious diseases. - September 6, 2023 Category: Allergy & Immunology Authors: Daniel Lazzari de Quadros Vitoria Agnoletto Ribeiro Mariana Antunes Rezende Yasmin Ampese Mat é M árcio Alexandro Gomes Katia Secchi Daisy Maria Strottmann Rafael Frandoloso Luiz Carlos Kreutz Source Type: research
Immunotherapy for acute myeloid leukemia: current trends, challenges, and strategies
Acta Haematol. 2023 Sep 6. doi: 10.1159/000533990. Online ahead of print.ABSTRACTBACKGROUND: In the past decade, there have been significant breakthroughs in immunotherapies for B-cell lymphoid malignancies and multiple myeloma, but progress has been much less for acute myeloid leukemia (AML). Nevertheless, challenge begets innovation and several therapeutic strategies are under investigation.SUMMARY: In this review, we review the state of the art in AML immunotherapy including CD33- and CD123-targeted agents, immune checkpoint inhibition, and adoptive cell therapy strategies. We also share conceptual frameworks for approa...
Source: Acta Haematologica - September 6, 2023 Category: Hematology Authors: Evan C Chen Jacqueline S Garcia Source Type: research
LIF signaling regulates outer radial glial to interneuron fate during human cortical development
Cell Stem Cell. 2023 Aug 29:S1934-5909(23)00292-8. doi: 10.1016/j.stem.2023.08.009. Online ahead of print.ABSTRACTRadial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia. However, the mechanisms regulating oRG differentiation are unclear. oRG cells express leukemia-inhibitory factor (LIF) receptors during neurogenesis, and consistent with a role in stem cell self-renewal, LIF perturbation impacts oRG proliferation in cortical tissue and organoids. Surprisingly, LIF treatment also increases t...
Source: Cell Stem Cell - September 6, 2023 Category: Stem Cells Authors: Madeline G Andrews Clara Siebert Li Wang Matthew L White Jayden Ross Raul Morales Megan Donnay Gradi Bamfonga Tanzila Mukhtar Arpana Arjun McKinney Kaila Gemenes Shaohui Wang Qiuli Bi Elizabeth E Crouch Neelroop Parikshak Georgia Panagiotakos Eric Huang A Source Type: research
Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF- κB activation
Biochim Biophys Acta Mol Cell Res. 2023 Sep 4:119571. doi: 10.1016/j.bbamcr.2023.119571. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) have favourable outcomes in the treatment of kidney diseases. Pre-B-cell leukaemia transcription factor 1 (PBX1) has been reported to be a regulator of self-renewal of stem cells. Whether PBX1 is beneficial to MSCs in the treatment of haemorrhagic shock (HS)-induced kidney damage is unknown. We overexpressed PBX1 in rat bone marrow-derived mesenchymal stem cells (rBMSCs) and human bone marrow-derived mesenchymal stem cells (hBMSCs) to treat rats with HS and hypoxia-treated hum...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Di Jia Jiahui Han Jimin Cai Zhirong Huan Yan Wang Xin Ge Source Type: research
A case of Hodgkin lymphoma-type Richter syndrome presenting as small-intestinal perforation
Int J Hematol. 2023 Sep 6. doi: 10.1007/s12185-023-03655-2. Online ahead of print.ABSTRACTHodgkin lymphoma type of Richter syndrome (HL-type RS) is a rare disease that arises in patients with chronic lymphocytic leukemia (CLL). HL-type RS lesions can manifest in various sites and are often accompanied by related symptoms. This is the first case report to describe diagnosis of HL-type RS after emergency surgery for gastrointestinal perforation caused by the development of a HL-type RS lesion. A 47-year-old man diagnosed with CLL three years prior began treatment with ibrutinib due to worsening anemia and splenomegaly two mo...
Source: International Journal of Hematology - September 6, 2023 Category: Hematology Authors: Kosuke Miki Reiki Ogasawara Shunsuke Sugimura Junichi Sugita Rintaro Nozu Keisuke Kojima Daisuke Hidaka Ai Shimizu Kohei Okada Naoki Kobayashi Masahiro Ogasawara Masahiro Imamura Yoshihiro Matsuno Shuichi Ota Source Type: research
Oncogenic viral DNA related to human breast cancer found on cattle milk and meat
Comp Immunol Microbiol Infect Dis. 2023 Aug 27;101:102053. doi: 10.1016/j.cimid.2023.102053. Online ahead of print.ABSTRACTBovine leukemia virus (BLV) is a major cause of lymphoma in cattle and has been recently correlated to breast cancer in humans. How and whether BLV might reach humans remains unknown but it could be through cattle-derived milk and meat. Here our aim was to investigate whether BLV DNA could be found in fresh milk and raw meat destined to human consumption and whether anti-BLV antibodies could be detected in human blood at the same geographical region. Milk (n = 36) and meat (n = 54) samples were collect...
Source: Comparative immunology, microbiology and infectious diseases. - September 6, 2023 Category: Allergy & Immunology Authors: Daniel Lazzari de Quadros Vitoria Agnoletto Ribeiro Mariana Antunes Rezende Yasmin Ampese Mat é M árcio Alexandro Gomes Katia Secchi Daisy Maria Strottmann Rafael Frandoloso Luiz Carlos Kreutz Source Type: research
Immunotherapy for acute myeloid leukemia: current trends, challenges, and strategies
Acta Haematol. 2023 Sep 6. doi: 10.1159/000533990. Online ahead of print.ABSTRACTBACKGROUND: In the past decade, there have been significant breakthroughs in immunotherapies for B-cell lymphoid malignancies and multiple myeloma, but progress has been much less for acute myeloid leukemia (AML). Nevertheless, challenge begets innovation and several therapeutic strategies are under investigation.SUMMARY: In this review, we review the state of the art in AML immunotherapy including CD33- and CD123-targeted agents, immune checkpoint inhibition, and adoptive cell therapy strategies. We also share conceptual frameworks for approa...
Source: Acta Haematologica - September 6, 2023 Category: Hematology Authors: Evan C Chen Jacqueline S Garcia Source Type: research
Design, synthesis and bioactivity evaluation of selenium-containing PI3K δ inhibitors
In conclusion, the Se-containing compound Se15 bearing pyrido[3,2-d]pyrimidine scaffold is a novel potent and selective PI3Kδ inhibitor. The introduction of selenium can enrich the structure of PI3Kδ inhibitors and provide a new idea for design of novel PI3Kδ inhibitors.PMID:37672953 | DOI:10.1016/j.bioorg.2023.106815
Source: Bioorganic Chemistry - September 6, 2023 Category: Chemistry Authors: Li Gao Hongyan Chuai Mengyan Ma San-Qi Zhang Jiye Zhang Jiyu Li Yang Wang Minhang Xin Source Type: research
CAR virus receptor mediates erythroid differentiation and migration and is downregulated in MDS
Leukemia. 2023 Sep 6. doi: 10.1038/s41375-023-02015-7. Online ahead of print.ABSTRACTMyelodysplastic syndromes (MDS) are myeloid neoplasms presenting with dysplasia in the bone marrow (BM) and peripheral cytopenia. In most patients anemia develops. We screened for genes that are expressed abnormally in erythroid progenitor cells (EP) and contribute to the pathogenesis of MDS. We found that the Coxsackie-Adenovirus receptor (CAR = CXADR) is markedly downregulated in CD45low/CD105+ EP in MDS patients compared to control EP. Correspondingly, the erythroblast cell lines HEL, K562, and KU812 stained negative for CAR. Lentiviral...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Karin Bauer Sigrid Machherndl-Spandl Lukas Kazianka Irina Sadovnik Sinan G ültekin Susanne Suessner Johannes Proell Jeroen Lauf Gregor Hoermann Gregor Eisenwort Norman H äfner Mathilde F ödermayr-Mayrleitner Ann-Sofie Schmolke Emiel van der Kouwe Uwe P Source Type: research
Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF- κB activation
Biochim Biophys Acta Mol Cell Res. 2023 Sep 4:119571. doi: 10.1016/j.bbamcr.2023.119571. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) have favourable outcomes in the treatment of kidney diseases. Pre-B-cell leukaemia transcription factor 1 (PBX1) has been reported to be a regulator of self-renewal of stem cells. Whether PBX1 is beneficial to MSCs in the treatment of haemorrhagic shock (HS)-induced kidney damage is unknown. We overexpressed PBX1 in rat bone marrow-derived mesenchymal stem cells (rBMSCs) and human bone marrow-derived mesenchymal stem cells (hBMSCs) to treat rats with HS and hypoxia-treated hum...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: Di Jia Jiahui Han Jimin Cai Zhirong Huan Yan Wang Xin Ge Source Type: research
Protective effects of macromolecular polyphenols, metal (zinc, selenium, and copper) - Polyphenol complexes, and pectin in different organs with an emphasis on arsenic poisoning: A review
Int J Biol Macromol. 2023 Sep 4:126715. doi: 10.1016/j.ijbiomac.2023.126715. Online ahead of print.ABSTRACTFor the potential health benefits and nutritional value, polyphenols are one of the secondary metabolites of plants that have received extensive research. It has anti-inflammatory and cytotoxicity-reducing properties in addition to a high antioxidant content. Macromolecular polyphenols and polysaccharides are biologically active natural polymers with antioxidant and anti-inflammatory potential. Arsenic is an ecologically toxic metalloid. Arsenic in drinking water is the most common way people come into contact with th...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Kaviyarasi Renu Anirban Goutam Mukherjee Abilash Valsala Gopalakrishnan Uddesh Ramesh Wanjari Sandra Kannampuzha Reshma Murali Vishnu Priya Veeraraghavan Sathishkumar Vinayagam Soraya Paz-Montelongo Alex George Balachandar Vellingiri Harishkumar Madhyasth Source Type: research
