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Therapeutic Potential of Ag(I)-, Au(I)-, Au(III)-NHC complexes of 3-pyridyl wingtip N-heterocyclic carbene (NHC) against lung cancer
New J. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3NJ02882H, PaperPrafulla K Behera, Lakshmikanta Maity, Sraddhya Roy, Ananya Das, Priyanka Sahu, Hemanta Kumar Kisan, Avtar Changotra, Anvarhusein Isab, Mohammed Fettouhi, Aparajita Bairagi, Nabanita Chatterjee, Joydev Dinda Herein we report the easy synthetic approaches, structural features, theoretical studies, and extensive bioactivity of [Ag(1)2][PF6] (2); [Au(1)2][PF6] (3); [Au(1)Cl3] (4) compounds prepared from the NHC precursor3-[pyridin-3-yl)]imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (1.HPF6). All... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 18, 2023 Category: Chemistry Authors: Prafulla K Behera Source Type: research
LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis
CONCLUSIONS: LINC00668 acted as an oncogene in NSCLC progression through miR-518c-3p/TRIP4 axis. Our study disclosed a new mechanism of LINC00668 functioned in NSCLC and may give a deeper insight of the targeted therapy of NSCLC in the future.PMID:37718780 | DOI:10.3233/CBM-230154
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Zhibin Lu Zhichao Xiao Qi Wang Chunfeng Pan Yang Xia Weibing Wu Liang Chen Source Type: research
Deep Learning-Based Feature Extraction from Whole-Body PET/CT Employing Maximum Intensity Projection Images: Preliminary Results of Lung Cancer Data
CONCLUSION: A 2-D image-based pre-trained model could extract image patterns of whole-body FDG PET volume by using anterior and lateral views of MIP images bypassing the direct use of 3-D PET volume that requires large datasets and resources. We suggest that this approach could be implemented as a backbone model for various applications for whole-body PET image analyses.PMID:37720886 | PMC:PMC10504178 | DOI:10.1007/s13139-023-00802-9
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Joonhyung Gil Hongyoon Choi Jin Chul Paeng Gi Jeong Cheon Keon Wook Kang Source Type: research
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer-Opportunities for Drug Repurposing
Appl Biochem Biotechnol. 2023 Sep 18. doi: 10.1007/s12010-023-04595-7. Online ahead of print.ABSTRACTGlobally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma. One of the most vital aspects for proper diagnosis, prognosis, and adequate therapy is the precise classification of non-small cell lung cancer based on biomarke...
Source: Applied Biochemistry and Biotechnology - September 18, 2023 Category: Biochemistry Authors: Rajdeep Kaur P K Suresh Source Type: research
Associations between longer leukocyte telomere length and increased lung cancer risk among never smokers in urban China
CONCLUSIONS: Longer pre-diagnostic leukocyte telomere length is associated with increased lung cancer risk among never smokers.IMPACT: Our findings firmly support the role of longer telomeres in lung carcinogenesis.PMID:37721487 | DOI:10.1158/1055-9965.EPI-23-0881
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Jason Yy Wong Xiao-Ou Shu Wei Hu Batel Blechter Jianxin Shi Kevin Wang Richard Cawthon Qiuyin Cai Gong Yang Mohammad L Rahman Bu-Tian Ji Yutang Gao Wei Zheng Nathaniel Rothman Qing Lan Source Type: research
Effect of postoperative radiotherapy on survival in patients with completely resected and pathologically confirmed stage N2 non-small-cell lung cancer: a systematic review and meta-analysis
CONCLUSION: Our results suggest that in the postoperative treatment of patients with completely resected and pathologically confirmed stage N2 NSCLC, the addition of PORT provides better local recurrence control and survival benefit, but no benefit for distant metastases. The PORT may be incorporated into the postoperative treatment options for some patients with high-risk factors. However, it needs to be validated by more prospective studies in the future.TRAIL REGISTRATION: CRD42022314095.PMID:37720592 | PMC:PMC10501070 | DOI:10.1177/20406223231195622
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Lin Wang Wenyu Chen Xiaofei Xu Wenbo Chen Derong Bao Ye Zhang Yufen Xu Source Type: research
Navigating the challenges of invasive pulmonary aspergillosis in lung cancer treatment: a propensity score study
CONCLUSIONS: IPA tended to be diagnosed more frequently in patients receiving chemotherapy or immune checkpoint inhibitors. Patients diagnosed with IPA are associated with shorter survival. Larger cohort studies are needed to verify the observations.PMID:37720497 | PMC:PMC10503299 | DOI:10.1177/17588359231198454
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Chin-Wei Kuo Chien-Yu Lin Sheng-Huan Wei Yun-Tse Chou Chian-Wei Chen Jeng-Shiuan Tsai Po-Lan Su Chien-Chung Lin Source Type: research
TPVB and general anesthesia affects postoperative functional recovery in elderly patients with thoracoscopic pulmonary resections based on ERAS pathway
CONCLUSION: Based on the ERAS pathway, TPVB combined with general anesthesia in thoracoscopic surgery for lung cancer in elderly patients can effectively reduce the patients' hemodynamic fluctuations, alleviate postoperative pain, accelerate the recovery process, and reduce complications.PMID:37719744 | PMC:PMC10500636 | DOI:10.1515/tnsci-2022-0305
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Na An Wenzhe Dong Guangdong Pang Yiwei Zhang Chunling Liu Source Type: research
< em > IL1RL1 < /em > polymorphisms rs12479210 and rs1420101 are associated with increased lung cancer risk in the Chinese Han population
Conclusion: Our findings suggest that IL1RL1 genetic variants (rs12479210 and rs1420101) are associated with an increased lung cancer risk in the Chinese Han population. These risk variants may serve as biomarkers for the prevention and treatment of lung cancer.PMID:37719702 | PMC:PMC10500304 | DOI:10.3389/fgene.2023.1183528
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Qi Li Chan Zhang Yujing Cheng Xin Yang Wanlu Chen Kunhua He Mingwei Chen Source Type: research
Safety and economic analysis of the EasyEndo disposable endoscopic cutting and stapling device for VATS lobectomy or segmentectomy in lung cancer patients: a retrospective study
CONCLUSION: The EasyEndo disposable endoscopic cutting and stapling device demonstrated comparable safety and effectiveness to the Johnson EC45A stapler in VATS segmentectomy for lung cancer patients. Moreover, the use of the EasyEndo stapler resulted in cost savings, indicating its potential economic benefits for healthcare institutions.PMID:37719012 | PMC:PMC10502227 | DOI:10.3389/fonc.2023.1247450
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Ziyang Han Jieming Lu Shuchen Chen Shaobin Yu Peipei Zhang Mingqiang Kang Source Type: research
Silencing lncRNA EZR ‑AS1 induces apoptosis and attenuates the malignant properties of lung adenocarcinoma cells
This study aimed to investigate the effect of silencing long non-coding RNA (lncRNA) EZR‑AS1 on the biological behaviors of lung adenocarcinoma (ADC) cells. EZR‑AS1 expression levels in lung ADC tissues and cells, as well as in adjacent non-cancerous tissues, were determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). EZR‑AS1 was knocked down in two lung ADC cell lines using small interfering RNA specific for EZR‑AS1 (siEZR‑AS1). Proliferation, migration, and apoptosis of EZR‑AS1-knockdown cells were assessed using the CCK-8 viability assay, flow cytometry, or wound healing exp...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Xianjing Yu Lixue Wu Zhongcui Lu Junli Zhang Yunfeng Zhou Source Type: research
Schweinfurthiamide, a new alkaloid isolated from the tuber roots of < em > Asparagus flagellaris < /em > Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Natural Product Research - September 18, 2023 Category: Biochemistry Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research
Effect of postoperative radiotherapy on survival in patients with completely resected and pathologically confirmed stage N2 non-small-cell lung cancer: a systematic review and meta-analysis
CONCLUSION: Our results suggest that in the postoperative treatment of patients with completely resected and pathologically confirmed stage N2 NSCLC, the addition of PORT provides better local recurrence control and survival benefit, but no benefit for distant metastases. The PORT may be incorporated into the postoperative treatment options for some patients with high-risk factors. However, it needs to be validated by more prospective studies in the future.TRAIL REGISTRATION: CRD42022314095.PMID:37720592 | PMC:PMC10501070 | DOI:10.1177/20406223231195622
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Lin Wang Wenyu Chen Xiaofei Xu Wenbo Chen Derong Bao Ye Zhang Yufen Xu Source Type: research
Pursuit or discontinuation of anti-PD1 after 2 years of treatment in long-term responder patients with non-small cell lung cancer
CONCLUSION: The decision to continue ICI or not after 2 years of treatment depends mainly on the care center and does not seem to impact survival. Larger, randomized data sets are required to confirm this result.PMID:37720494 | PMC:PMC10501064 | DOI:10.1177/17588359231195600
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Camille Ardin Sarah Humez Vincent Leroy Alexandre Ampere Soraya Bordier Fabienne Escande Am élie Turlotte Luc Stoven David Nunes Alexis Cortot Cl ément Gauvain Source Type: research
Overall signature of acquired KRAS gene changes in advanced non-small cell lung cancer patient with EGFR-TKI resistance
CONCLUSIONS: This study provides significant evidence of the role of acquired KRAS variants in the development of resistance to epidermal growth factor receptor-tyrosine kinase inhibitor therapy. Our results contribute to the growing body of knowledge on the mutational profiles associated with resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment. Furthermore, our study highlights the KRAS gene change as a significant mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitor therapy.PMID:37721193 | DOI:10.1093/jjco/hyad123
Source: Clinical Lung Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Jie Zheng Yuanyao Dou Daijuan Huang Yubo Wang Rui Han Chen Hu Mengxiao Zhu Conghua Lu Caiyu Lin Di Wu Yihui Liu Huan Tang Tingting He Weilin Jiang Yong He Source Type: research
