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Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
CONCLUSION: Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.PMID:37710179 | PMC:PMC10503112 | DOI:10.1186/s12575-023-00217-y
Source: Biological Procedures Online - September 14, 2023 Category: Molecular Biology Authors: Min Wu Shihao Wu Yuetong Chen Liangchao Sun Jundong Zhou Source Type: research
Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning
CONCLUSION: This study is the first to analyze the difference between metabolomics and lipidomics and to construct a d-model to detect SCLC using integrated machine learning. This study may be of great significance for the screening and early diagnosis of SCLC patients.PMID:37706531 | DOI:10.1093/oncolo/oyad261
Source: The Oncologist - September 14, 2023 Category: Cancer & Oncology Authors: Xiaoling Shang Chenyue Zhang Ronghua Kong Chenglong Zhao Haiyong Wang Source Type: research
Pain-related stigma in patients with breast, colon, prostate or lung cancer : Results of a bicentric register-based cross-sectional study
CONCLUSIONS: Our findings support the assumption that the experience of pain can have an impact on the perceived stigmatization of cancer patients. Depression might influence the perceived stigmatization. Therefore, this group of patients should receive special attention and psycho-oncological care in clinical practice. Further research on the course and mechanisms of action of pain-related perceived stigmatization is also required.PMID:37710022 | DOI:10.1007/s00482-023-00752-3
Source: Schmerz - September 14, 2023 Category: Anesthesiology Authors: A Roicke P Esser B Hornemann J Ernst Source Type: research
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
CONCLUSION: Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.PMID:37710179 | PMC:PMC10503112 | DOI:10.1186/s12575-023-00217-y
Source: Biological Procedures Online - September 14, 2023 Category: Molecular Biology Authors: Min Wu Shihao Wu Yuetong Chen Liangchao Sun Jundong Zhou Source Type: research
CT-based non-invasive identification of the most common gene mutation status in patients with non-small cell lung cancer
CONCLUSIONS: Our study demonstrates the potential of radiomics in the non-invasive identification of EGFR and KRAS mutation status, which may guide patients with non-small cell lung cancer to choose the most appropriate personalized treatment. This method can be used when biopsy will bring unacceptable risk to patients with NSCLC.PMID:37706584 | DOI:10.1002/mp.16744
Source: Health Physics - September 14, 2023 Category: Physics Authors: Zongjian Chen Si Gao Changwei Ding Ting Luo Jiaqi Xu Shuang Xu Shu Li Source Type: research
Pain-related stigma in patients with breast, colon, prostate or lung cancer : Results of a bicentric register-based cross-sectional study
CONCLUSIONS: Our findings support the assumption that the experience of pain can have an impact on the perceived stigmatization of cancer patients. Depression might influence the perceived stigmatization. Therefore, this group of patients should receive special attention and psycho-oncological care in clinical practice. Further research on the course and mechanisms of action of pain-related perceived stigmatization is also required.PMID:37710022 | DOI:10.1007/s00482-023-00752-3
Source: Schmerz - September 14, 2023 Category: Anesthesiology Authors: A Roicke P Esser B Hornemann J Ernst Source Type: research
Survival outcomes of east Asian patients with advanced non ‐small cell lung cancer treated with first‐line EGFR tyrosine kinase inhibitors: A network meta‐analysis of real‐world evidence
ConclusionsThis real-world evidence shows that afatinib confers better survival than other first-line EGFR-TKIs in East Asian patients with advanced NSCLC.
Source: Thoracic Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Huang ‐Chih Chang,
Kuo‐Tung Huang,
Chia‐Cheng Tseng,
Yu‐Mu Chen,
Chien‐Hao Lai,
Yu‐Ping Chang,
Yung‐Che Chen,
Hung‐Yi Chuang,
Chin‐Chou Wang Tags: ORIGINAL ARTICLE Source Type: research
Fenretinide induces apoptosis and synergises the apoptosis inducing effect of gemcitabine through inhibition of key signalling molecules involved in A549 cell survival in in silico and in vitro analyses
In conclusion, Akt may be exploited as a good target for induction of apoptosis in A549 cells and fenretinide has great potentials to fulfil this task. The mechanism by which fenretinide boosts the apoptosis inducing effects of gemcitabine, which is likely expected to be via inhibiting mTORC2 downstream targets. However, docking investigation revealed that fenretinide lacks specificity as it may also interact with several secondary targets beside Akt.PMID:37704095 | DOI:10.1016/j.cellsig.2023.110885
Source: Cellular Signalling - September 13, 2023 Category: Cytology Authors: Hazem A Al-Bustany Hawzheen A Muhammad Mahmoud A Chawsheen Phil R Dash Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Identification of DNA variants at ultra-low variant allele frequencies via Taq polymerase cleavage of wild-specific blockers
Anal Bioanal Chem. 2023 Sep 13. doi: 10.1007/s00216-023-04931-0. Online ahead of print.ABSTRACTDetecting mutations related to tumors holds immense clinical significance for cancer diagnosis and treatment. However, the presence of highly redundant wild DNA poses a challenge for the advancement of low-copy mutant ctDNA genotyping in cancer cases. To address this, a Taqman qPCR strategy to identify rare mutations at low variant allele fractions (VAFs) has been developed. This strategy combines mutant-specific primers with wild-specific blockers. Diverging from other blocker-mediated PCRs, which rely on primer-induced strand d...
Source: Analytical and Bioanalytical Chemistry - September 13, 2023 Category: Chemistry Authors: Zhaocheng Liu Xiushuai Li Rui Zhang Li Ji Lingli Gong Yong Ji Fengsheng Zhou Ying Yin Koukou Li Ping Sun Zhening Pu Qing Wang Jian Zou Source Type: research
A novel synthesized prodrug of gemcitabine based on oxygen-free radical sensitivity inhibited the growth of lung cancer cells
J Biomed Res. 2023 Sep 28:1-12. doi: 10.7555/JBR.37.20230022. Online ahead of print.ABSTRACTIn the present study, we introduced the H 2O 2-sensitive thiazolidinone moiety at the 4th amino group of gemcitabine (GEM) to synthesize a new target compound named GEM-ZZQ, and then we confirmed its chemical structure by nuclear magnetic resonance spectroscopy. We further confirmed that GEM-ZZQ had a good chemical stability in different pH solutions in vitro and that it could be activated by H 2O 2 to release GEM. Pharmacodynamic studies revealed that the growth inhibition of human normal epithelial cells was weaker by GEM-ZZQ than...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Xinlu Chai Yuting Meng Wei Ge Juan Wang Fei Li Xue Jun Wang Xuerong Wang Source Type: research
Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer
CONCLUSION: Our study identified SCLC-specific exosomal miRNAs, and the 3-miRNAs panel (miR-200b-3p, miR-3124-5p and miR-92b-5p) may serve as a diagnostic and prognostic marker for SCLC.PMID:37705067 | DOI:10.1186/s40364-023-00517-1
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Dong Ha Kim Hyojeong Park Yun Jung Choi Kyungtaek Im Chae Won Lee Da-Som Kim Chan-Gi Pack Hyun-Yi Kim Chang-Min Choi Jae Cheol Lee Wonjun Ji Jin Kyung Rho Source Type: research
Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non-Small Cell Lung Cancer
CONCLUSIONS: ctDNA monitoring during induction chemoIO can inform treatment outcomes in patients with advanced NSCLC. Importantly, monitoring remains feasible and informative for patients missing baseline ctDNA. ctDNA testing during induction chemoIO identifies patients at higher risk for disease progression and may inform patient selection for novel personalized maintenance or second line treatment strategies.PMID:37702716 | DOI:10.1158/1078-0432.CCR-23-1578
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Bruna Pellini Russell W Madison Merrida Childress Shoshana T Miller Ole Gjoerup Jason Cheng Richard S P Huang Michael Krainock Pratyush Gupta Wei Zou David S Shames Solomon Moshkevich Marcus Ballinger Minetta C Liu Amanda Young Minu K Srivastava Geoffrey Source Type: research
Molecular docking analysis of mefluhybenamine with lung cancer targets
Bioinformation. 2022 Dec 31;18(12):1186-1191. doi: 10.6026/973206300181186. eCollection 2022.ABSTRACTLung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. There...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Youssef S Alghamdi Source Type: research
