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Vaccination: Influenza Vaccine

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Total 427 results found since Jan 2013.

Safety assessment of seasonal trivalent influenza vaccine produced by Instituto Butantan from 2013 to 2017.
Abstract Vaccination has been a successful strategy in influenza prevention. However, despite the safety and efficacy of the vaccines, they can cause adverse events following immunization (AEFI). Moreover, due to the vaccination success, most of vaccine-preventable diseases (VPD) have become rare, and public attention has been shifted from VPD to the AEFI associated with vaccination. This manuscript describes the safety of Instituto Butantan (IB) seasonal trivalent influenza vaccine (TIV) from 2013 to 2017. AEFI data were received by the Department of Pharmacovigilance of IB (PV-IB), from January the 1st 2013 to D...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - December 20, 2018 Category: Tropical Medicine Authors: Gattás VL, Braga PE, Koike ME, Lucchesi MBB, Oliveira MMM, Piorelli RO, Queiroz V, Precioso AR Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Needle-free delivery of DNA: Targeting of hemagglutinin to MHC class II molecules protects rhesus macaques against H1N1 influenza.
Abstract Conventional influenza vaccines are hampered by slow and limited production capabilities, whereas DNA vaccines can be rapidly produced for global coverage in the event of an emerging pandemic. However, a drawback of DNA vaccines is their generally low immunogenicity in non-human primates and humans. We have previously demonstrated that targeting of influenza hemagglutinin to human HLA class II molecules can increase antibody responses in larger animals such as ferrets and pigs. Here, we extend these observations by immunizing non-human primates (rhesus macaques) with a DNA vaccine encoding a bivalent fusi...
Source: Vaccine - January 9, 2019 Category: Allergy & Immunology Authors: Mooij P, Grødeland G, Koopman G, Andersen TK, Mortier D, Nieuwenhuis IG, Verschoor EJ, Fagrouch Z, Bogers WM, Bogen B Tags: Vaccine Source Type: research

Needle-free delivery of influenza vaccine using the Med-Jet ® H4 is efficient and elicits the same humoral and cellular responses as standard IM injection: A randomized trial.
CONCLUSIONS: These data suggest that the Med-Jet is an acceptable means of delivering seasonal influenza vaccine. The system was attractive to subjects, rapidly learned by skilled vaccine nurses and elicited both humoral and cellular responses that were indistinguishable from those elicited with needle injection. While other studies have assessed the humoral response to jet injection of influenza vaccine, to our knowledge, this study is the first to assess the cellular aspect of this response. (ClinTrials.gov-NCT03150537). PMID: 30709725 [PubMed - as supplied by publisher]
Source: Vaccine - January 29, 2019 Category: Allergy & Immunology Authors: Shapiro JR, Hodgins B, Hendin HE, Patel A, Menassa K, Menassa C, Menassa M, Pereira JA, Ward BJ Tags: Vaccine Source Type: research

A case of neuromyelitis optica spectrum disorder following seasonal influenza vaccination
We report a case of neuromyelitis optica spectrum disorder following seasonal influenza vaccination. Neuromyelitis optica spectrum disorder may have been triggered by the recent influenza vaccination, although a pathogenic link has not been established.
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Post-licensure surveillance of trivalent adjuvanted influenza vaccine (aIIV3; Fluad), Vaccine Adverse Event Reporting System (VAERS), United States, July 2016-June 2018.
CONCLUSIONS: Although our review of aIIV3 in VAERS did not identify any unexpected health conditions of concern, we observed more than twice the expected number of reports with administration of the vaccine to persons outside of the age range for which the vaccine is approved in the U.S. Health care providers should be educated on the age groups for whom aIIV3 is recommended. PMID: 30739795 [PubMed - as supplied by publisher]
Source: Vaccine - February 7, 2019 Category: Allergy & Immunology Authors: Haber P, Moro PL, Ng C, Dores GM, Lewis P, Cano M Tags: Vaccine Source Type: research

2019 Health Law Professors Conference
Conclusion
Source: blog.bioethics.net - March 27, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs

Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid
In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

The Safety and Immunogenicity of a Cell-Derived Adjuvanted H5N1 Vaccine – A Phase I Randomized Clinical Trial
ConclusionsThis Phase I trial showed the MDCK-derived H5N1 candidate vaccine is safe and immunogenic. The source of RBCs has a significant impact on the measurement of HAI titers (ClinicalTrials.gov number: NCT01675284.).
Source: Journal of Microbiology, Immunology and Infection - May 18, 2019 Category: Microbiology Source Type: research

Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention.
CONCLUSIONS: Overall, ZVL was 65% effective against PHN. It was effective in all age groups and provided moderate protection through 8 years. PMID: 31301920 [PubMed - as supplied by publisher]
Source: Vaccine - July 9, 2019 Category: Allergy & Immunology Authors: Klein NP, Bartlett J, Fireman B, Marks MA, Hansen J, Lewis E, Aukes L, Saddier P Tags: Vaccine Source Type: research

Cell-Based Quadrivalent Inactivated Influenza Virus Vaccine (Flucelvax ® Tetra/Flucelvax Quadrivalent ® ): A Review in the Prevention of Influenza
AbstractManufacturing influenza virus vaccines using a mammalian cell line rather than embryonated chicken eggs may carry certain advantages. A quadrivalent inactivated influenza virus vaccine produced using the Madin Darby canine kidney cell line has been approved in the EU (Flucelvax® Tetra) and USA (Flucelvax Quadrivalent®; QIVc hereafter) for the prevention of influenza in adults and children. The clinical development of QIVc has built upon that of a cell-based trivalent influenza virus vaccine (TIVc) manufactured using the same processes; the additional influenza B strain contained in QIVc reduces the risk of the st...
Source: Drugs - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Respiratory Virus Infections in People Over 14 Years of Age in Poland in the Epidemic Season of 2017/18.
In this study we demonstrate the results of examination of 4,507 people aged over 14 years toward the influenza infection in the epidemic season of 2017/18. Most of the confirmed infections were reported in older people aged over 65, a high-risk population group. A low percentage of the vaccinated population may affect an increased number of confirmed influenza viruses in the elderly. The findings demonstrate a need to increase awareness of vaccination benefits, which is particularly essential to avoid influenza infection in the elderly. PMID: 31559569 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - September 28, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis --- United States, 2013--2017
During 2013-2017, reported methamphetamine, injection drug, and heroin use increased substantially among women and heterosexual men with primary and secondary syphilis.
Source: CDC Morbidity and Mortality Weekly Report - February 14, 2019 Category: American Health Tags: Acute-Care Hospitals Influenza (Flu) Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Overdose Pain management Synthetic Opioids Syphilis (Treponema pallidum Infection) Women's Health Source Type: news

Transmission Patterns in a Low HIV-Morbidity State --- Wisconsin, 2014--2017
Most human immunodeficiency virus (HIV) molecular linkages in Wisconsin were among persons within the same racial/ethnic, risk, and age groups. Among named partner linkages where both persons had an HIV virus sequence available, 33.8% also had a molecular linkage and were deemed plausible transmission partners.
Source: CDC Morbidity and Mortality Weekly Report - February 14, 2019 Category: American Health Tags: Acute-Care Hospitals HIV/AIDS HIV/AIDS and STDs Influenza (Flu) Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Overdose Pain management Synthetic Opioids Syphilis (Treponema pallidum Infection) Women's Health Source Type: news

Shoulder Injury Related to Vaccine Administration (SIRVA): Petitioner claims to the National Vaccine Injury Compensation Program, 2010-2016.
CONCLUSIONS: Most conceded claims for SIRVA were in women and involved influenza vaccines. Injection too high on the arm could be a factor due to the risk of injecting into underlying non-muscular tissues. Healthcare providers should be aware of proper injection technique and anatomical landmarks when administering vaccines. PMID: 31771864 [PubMed - as supplied by publisher]
Source: Vaccine - November 22, 2019 Category: Allergy & Immunology Authors: Hesse EM, Atanasoff S, Hibbs BF, Adegoke OJ, Ng C, Marquez P, Osborn M, Su JR, Moro PL, Shimabukuro T, Nair N Tags: Vaccine Source Type: research