Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid

In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted in effective suppression of ZIKV replication with similar IC50. Importantly, the inhibitory effect of ATA on ZIKV infection was effective against strains of the African and Asian/American lineages, indicating that this inhibitory effect was not strain dependent. Overall, these results demonstrate that ATA has potent inhibitory activity against ZIKV replication and may be considered as a potential anti-ZIKV therapy for future clinical evaluation. Introduction Zika virus (ZIKV) belongs to the genus Flavivirus within the Flaviviridae family. ZIKV is an enveloped positive sense single-stranded RNA virus with a genome size of ∼10.7 kb that encodes a single polyprotein, which is post-translationally processed by cellular and viral proteases into three structural (capsid, C; pre-membrane, prM; and envelope, E) and seven non-structural (NS1, NS2A, NS2B,...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Brand C, Sehn AP, Gaya AR, Mota J, Brazosayavera J, Pollo Renner JD, Reuter CP Abstract PURPOSE: To verify the moderator role of physical fitness in the relationship betweenadiposity and cardiometabolic risk factors in normal weight and overweight/obese children and adolescents. METHODS: Cross-sectional study comprising 2482 children and adolescents, aged 7-17 years. Physical fitness was evaluated according the procedures of Projeto Esporte Brazil, and waist circumference (WC) with an inelastic tape. Cardiometabolic risk score was defined by the z-score sum of glucose, total cholesterol, high-density l...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
From an intensive care nurse to a homeless restaurant worker, four people changed by Covid-19 reflect on the most intense chapter of their livesOn 21 February, McFarlane, 57, was on her way back to Bangkok airport with her husband, Archie. The couple had been visiting their son, who works at an international school. “We felt apprehensive because the virus was starting to hit the news,” she recalls. She wore a mask at the airport and on the flight, though her husband refused. At Heathrow, nobody took their temperature or handed out hygiene leaflets, unlike in Bangkok. “You wouldn’t have known anythin...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Medical research Science Schools Education Nursing Health Society Microbiology Homelessness Social exclusion Housing Poverty Communities Source Type: news
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Fourth of July holiday weekend starts 53,000 new cases on Friday; WHO changes timeline of how it was alerted to virus; England ’s pubs reopen. Follow all the developments liveWhat we ’re learning about Covid as US states open upHow Victoria ’s outbreak divided AustraliaScotland and Wales attack UK government ’s shambolic travel changes9.22amBSTI just spoke toHana, a woman who lives in one of the nine public housing tower blocks that has been placed into lockdown in Melbourne.She learned of the lockdown when she returned home from the supermarket, just after 4pm, and was greeted by dozens of police o...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science US news UK news Source Type: news
Publication date: Available online 2 July 2020Source: EpidemicsAuthor(s): Stefan Engblom, Robin Eriksson, Stefan Widgren
Source: Epidemics - Category: Epidemiology Source Type: research
acute;sek I Abstract Age-related dynamics of protozoan and helminth infections in the red-legged partridge, Alectoris rufa, were studied in an intensive breeding aviary in the Czech Republic before releasing birds for hunting purposes. Pooled fecal samples (n = 900) were examined over 3 rearing seasons (2012-2014). A total of 4 protozoan species, Cryptosporidium baileyi, Cryptosporidium meleagridis, Eimeria kofoidi, and Eimeria legionensis, and 4 helminths, Capillaria phasianina, Eucoleus perforans, Heterakis gallinarum, and Syngamus trachea, was found. The most common parasite was S. trachea (prevalence 20-26%) i...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
BACKGROUND: Understand the traffic health beliefs and traffic risk behaviors among secondary technical vocational school students, explore the relationship between health beliefs and traffic risk behaviors, and to provide proof and direction for further t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Chronic pain is a complex experience that has now become a major public health issue. This has prompted many researchers to study attention, understanding it to be a crucial factor that allows altering the experience of pain, while attributing considerable...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Suicidal acts, both fatal and nonfatal, have increased in the United States over the past several years (1 –5), as have heavy drinking and alcohol use disorders (6–8), especially among women (7, 8), making the topic of the article by Edwards and col...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they produce. The increasingly higher doses that patients require...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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