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Attempt to identify antimicrobial Tridax procumbens (TP) mechanical properties using experimental work coupled with FEM model for biomedical applications
In this study, fresh TP liquid extracts blended with carboxymethylcellulose (CMC) biofilm were developed through the solution casting method. The casted film was tested for tensile strength through the Universal Tensile Tester (UTT), and the results were compared with the Finite Element Numerical Model (FEM) through the FEM code developed on the ANSYS solver. The experimental mean tensile test results for pure CMC were found as follows: tensile stress at the maximum of 15.31 MPa, modulus of elasticity of 7,24 GPa, the density of 1,62 g/cm3, and Poisson's ratio of 0.22. The experimental mean tensile test results for pure CM...
Source: Journal of the Mechanical Behavior of Biomedical Materials - August 28, 2023 Category: Materials Science Authors: C Balaji Ayyanar Sofiene Helaili Sanjay Mavinkere Rangappa Pawinee Boonyasopon Suchart Siengchin Source Type: research

A comparative study on essential oils from the leaves and stems of Vietnamese < em > Mikania micrantha < /em > Kunth
In this study, the essential oils from leaves and stems of M. micrantha were extracted by hydrodistillation method, and the chemical profiles of essential oils were then analysed by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). It was found that there were similarities and differences in chemical compositions and their percentage between the essential oils obtained from these two parts. The dominant components of leaves essential oil are β-Cubebene, Germacrene D, and α-Zingiberene, accounting for 11.34%, 10.96%, and 10.76%, respectively. Additionally, the major components of stems...
Source: Natural Product Research - August 28, 2023 Category: Biochemistry Authors: Quoc Trung Nguyen Khanh Ly Huynh Thi Minh Phuc Nguyen Thien Trinh Ngoc Thach Pham Minh Nhut Ho Yen Nhi Tran Thi Ngoc Quyen Tran Phuong Le Thi Source Type: research

A propensity score matched comparison of blood pressure lowering in essential hypertension patients treated with antihypertensive Chinese herbal Medicine: comparing the real-world registry data vs. randomized controlled trial
CONCLUSION: The current comparison demonstrated that SXC monotherapy is at least as effective in real-world settings as within the randomized controlled trial for BP lowering in patients with grade 1 hypertension.PMID:37639695 | DOI:10.1080/10641963.2023.2249269
Source: Clinical and Experimental Hypertension - August 28, 2023 Category: Cardiology Authors: Xinxing Lai Zhenghao Fang Zhenyu Dong Shengxian Wu Xiaohua Zhou Ying Gao Source Type: research

A comparative study on essential oils from the leaves and stems of Vietnamese < em > Mikania micrantha < /em > Kunth
In this study, the essential oils from leaves and stems of M. micrantha were extracted by hydrodistillation method, and the chemical profiles of essential oils were then analysed by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). It was found that there were similarities and differences in chemical compositions and their percentage between the essential oils obtained from these two parts. The dominant components of leaves essential oil are β-Cubebene, Germacrene D, and α-Zingiberene, accounting for 11.34%, 10.96%, and 10.76%, respectively. Additionally, the major components of stems...
Source: Natural Product Research - August 28, 2023 Category: Biochemistry Authors: Quoc Trung Nguyen Khanh Ly Huynh Thi Minh Phuc Nguyen Thien Trinh Ngoc Thach Pham Minh Nhut Ho Yen Nhi Tran Thi Ngoc Quyen Tran Phuong Le Thi Source Type: research

Integrated metabolic profiling and transcriptome analysis of Lonicera japonica flowers for chlorogenic acid, luteolin and endogenous hormone syntheses
In this study, transcriptomics and metabolomics were performed to reveal the regulatory mechanism of secondary metabolites during flowering of L. japonica. The results showed that the content of chlorogenic acid (CGA) and luteolin gradually decreased from green bud stage (Sa) to white flower stage (Sc), especially from white flower bud stage (Sb) to Sc. Most of the genes encoding the crucial rate-limiting enzymes, including PAL, C4H, HCT, C3'H, F3'H and FNSII, were down-regulated in three comparisons. Correlation analysis identified some members of the MYB, AP2/ERF, bHLH and NAC transcription factor families that are close...
Source: Gene - August 26, 2023 Category: Genetics & Stem Cells Authors: Renwei Guan Fengdan Guo Ruiqi Guo Shu Wang Xinru Sun Qiuchen Zhao Cuicui Zhang Shengbo Li Huibin Lin Jianqiang Lin Source Type: research

Chemical profiling and simultaneous quantification of major bioactive constituents from Cocculus hirsutus by UPLC-QqQ-MS
J Pharm Biomed Anal. 2023 Aug 20;235:115675. doi: 10.1016/j.jpba.2023.115675. Online ahead of print.ABSTRACTCocculus hirsutus is a widely used herb in traditional systems of medicine for the treatment of various diseases. In the present study, five alkaloids (1-5), two flavonoids (6-7), one triterpenoid (8), and three steroids (9-10) were isolated from the roots of Cocculus hirsutus and further crude extract was analyzed by LC-Q-Tof-MS/MS in positive ionization mode leading to the identification of ten metabolites through comparison of exact molecular masses from their MS/MS spectra, mass fragmentation studies and with lit...
Source: Biomed Res - August 26, 2023 Category: Research Authors: Kiran Kumar Tatapudi Siva Bandi Narendra Kumar Nagendla Divya Reddy Solipeta Mohana Krishna Reddy Mudiam Suresh Babu Katragadda Source Type: research

Integrated metabolic profiling and transcriptome analysis of Lonicera japonica flowers for chlorogenic acid, luteolin and endogenous hormone syntheses
In this study, transcriptomics and metabolomics were performed to reveal the regulatory mechanism of secondary metabolites during flowering of L. japonica. The results showed that the content of chlorogenic acid (CGA) and luteolin gradually decreased from green bud stage (Sa) to white flower stage (Sc), especially from white flower bud stage (Sb) to Sc. Most of the genes encoding the crucial rate-limiting enzymes, including PAL, C4H, HCT, C3'H, F3'H and FNSII, were down-regulated in three comparisons. Correlation analysis identified some members of the MYB, AP2/ERF, bHLH and NAC transcription factor families that are close...
Source: Gene - August 26, 2023 Category: Genetics & Stem Cells Authors: Renwei Guan Fengdan Guo Ruiqi Guo Shu Wang Xinru Sun Qiuchen Zhao Cuicui Zhang Shengbo Li Huibin Lin Jianqiang Lin Source Type: research

< em > Lavandula austroapennina < /em > : Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs
This study underlines how much knowledge of a territory's medicinal plant heritage is a harbinger of promising discoveries in the health field.PMID:37631991 | PMC:PMC10457779 | DOI:10.3390/v15081648
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Annalisa Chianese Claudia Gravina Maria Vittoria Morone Annalisa Ambrosino Marialuisa Formato Francesca Palma Francesco Foglia Bianca Maria Nastri Carla Zannella Assunta Esposito Anna De Filippis Simona Piccolella Massimiliano Galdiero Severina Pacifico Source Type: research

Chemical profiling and simultaneous quantification of major bioactive constituents from Cocculus hirsutus by UPLC-QqQ-MS
J Pharm Biomed Anal. 2023 Aug 20;235:115675. doi: 10.1016/j.jpba.2023.115675. Online ahead of print.ABSTRACTCocculus hirsutus is a widely used herb in traditional systems of medicine for the treatment of various diseases. In the present study, five alkaloids (1-5), two flavonoids (6-7), one triterpenoid (8), and three steroids (9-10) were isolated from the roots of Cocculus hirsutus and further crude extract was analyzed by LC-Q-Tof-MS/MS in positive ionization mode leading to the identification of ten metabolites through comparison of exact molecular masses from their MS/MS spectra, mass fragmentation studies and with lit...
Source: Biomed Res - August 26, 2023 Category: Research Authors: Kiran Kumar Tatapudi Siva Bandi Narendra Kumar Nagendla Divya Reddy Solipeta Mohana Krishna Reddy Mudiam Suresh Babu Katragadda Source Type: research

< em > Lavandula austroapennina < /em > : Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs
This study underlines how much knowledge of a territory's medicinal plant heritage is a harbinger of promising discoveries in the health field.PMID:37631991 | DOI:10.3390/v15081648
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Annalisa Chianese Claudia Gravina Maria Vittoria Morone Annalisa Ambrosino Marialuisa Formato Francesca Palma Francesco Foglia Bianca Maria Nastri Carla Zannella Assunta Esposito Anna De Filippis Simona Piccolella Massimiliano Galdiero Severina Pacifico Source Type: research

Don ’ t Get Dragged Down By “ Zombie Cells ”
Did you watch any of the zombie shows that were all over the airways a few years back? I confess my sons and I really got into the program The Walking Dead. Watching the cast of characters try to survive in a world overrun by dead zombies was a fun way to spend some time together and wrap up a Sunday night. Typically, when I think of the word “zombie,” I’m thinking of science fact, not fiction… Zombie cells are known scientifically as senescent cells. These are dysfunctional cells that have stopped dividing and are nearing the end of their natural lives. Zombie cells are too sick and damaged to carry out the...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news

Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations
CONCLUSION: In conclusion, there are many anti-arthritic herbal and synthetic medicine available in the market that are currently used in the treatment of RA. However, chronic use of these medications may result in a variety of side effects. Because therapy for RA is frequently necessary for the rest of ones life. The use of natural products may be a better option for RA management. These phytoconstituents, however, have several disadvantages, including limited bioavailability, low stability, and the need for a greater dosage. These problems can be rectified by using nano-technology.PMID:37622715 | DOI:10.2174/1567201821666230825102748
Source: Current Drug Delivery - August 25, 2023 Category: Drugs & Pharmacology Authors: Jyoti Prabha Mohit Kumar Devesh Kumar Shruti Chopra Amit Bhatia Source Type: research

Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D
In conclusion, a comprehensive proteomics study was performed on PD-treated or untreated TNBC cells, revealing the anticancer mechanisms of PD.PMID:37624509 | DOI:10.1007/s12010-023-04679-4
Source: Applied Biochemistry and Biotechnology - August 25, 2023 Category: Biochemistry Authors: Chuanchao Wei Anwei Mao Yongzhi Liu Qing Zhang Gaofeng Pan Weiyan Liu Jiazhe Liu Source Type: research

< em > Moringa oleifera < /em > : A Review on the Antiproliferative Potential in Breast Cancer Cells
Curr Issues Mol Biol. 2023 Aug 18;45(8):6880-6902. doi: 10.3390/cimb45080434.ABSTRACTThe global burden of female breast cancer and associated deaths has become a major concern. Many chemotherapeutic agents, such as doxorubicin, have been shown to have adverse side effects. The development of multi-drug resistance is a common occurrence, contributing to chemotherapeutic failure. The resistance of breast cancer cells to drug treatment leads to a decline in the treatment efficacy and an increase in cancer recurrence. Therefore, action is required to produce alternative drug therapies, such as herbal drugs. Herbal drugs have b...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Malebogo M Moremane Beynon Abrahams Charlette Tiloke Source Type: research

The Effect of the Mixed Extract of < em > Kalopanax pictus < /em > Nakai and < em > Achyranthes japonica < /em > Nakai on the Improvement of Degenerative Osteoarthritis through Inflammation Inhibition in the Monosodium Iodoacetate-Induced Mouse Model
The objective of this study is to confirm the potential of a mixture extract of Kalopanax pictus Nakai and Achyranthes japonica Nakai as a functional raw material for improving osteoarthritis through anti-inflammatory effects in macrophages and MIA-induced arthritis experimental animals. In macrophages inflamed by lipopolysaccharide (LPS), treatment of Kalopanax pictus Nakai and Achyranthes japonica Nakai mixture inhibits NF-κB and mitogen-activated protein kinase (MAPK) activities, thereby inhibiting inflammatory cytokine tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), inflammatory factors PGE2, MMP-2, and...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Hak-Yong Lee Young-Mi Park Hai-Min Hwang Dong-Yeop Shin Han-Na Jeong Jae-Gon Kim Hyo-Yeon Park Dae-Sung Kim Jin-Joo Yoo Myung-Sunny Kim Min-Jung Kim Hye-Jeong Yang Soo-Cheol Choi In-Ah Lee Source Type: research