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Nutrition: Potassium

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Total 1055 results found since Jan 2013.

Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain
Osteoarthritic pain has a strong impact on patients ’ quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCN Q2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. The activation of KCNQ/M channels with flupirtine significantly increased the mechanical threshold and prolonged the withdrawal latency of osteoarthritic mo...
Source: Pharmacology - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Expression of KCNA2 in the dorsal root ganglia of rats with osteoarthritis pain induced by monoiodoacetate.
CONCLUSIONS: The expression of KCNA2 is decreased in the DRG neurons of rats with OA pain likely as a result of enhanced methylation of Kcna2 promoter region. PMID: 31140423 [PubMed - in process]
Source: Journal of Southern Medical University - May 29, 2019 Category: Universities & Medical Training Authors: Zhao Q, Wang Q, Xu J, Wang J, Deng X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Interleukin 6 decreases nociceptor expression of the potassium channel KV1.4 in a rat model of hand–arm vibration syndrome
Chronic muscle pain is a prominent symptom of the hand–arm vibration syndrome (HAVS), an occupational disease induced by exposure to vibrating power tools, but the underlying mechanism remains unknown. We evaluated the hypothesis that vibration induces an interleukin 6 (IL-6)-mediated downregulation of the potassium voltage-gated channel subfamily A member 4 (KV1.4) in nociceptors leading to muscle pain. Adult male rats were submitted to a protocol of mechanical vibration of the right hind limb. Twenty-four hours after vibration, muscle hyperalgesia was observed, concomitant to increased levels of IL-6 in the gastrocnemi...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain.
CONCLUSIONS: IA current is decreased in DRG neurons from rats with CIBP. Cinobufagin can regulate the activation and inactivation of IA current in the DRG cells, which may be related to its analgesic mechanism. PMID: 31640967 [PubMed - in process]
Source: Journal of Southern Medical University - September 29, 2019 Category: Universities & Medical Training Authors: Zhu S, Liu D, Hu W, Yang H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Epigenetic Restoration of Voltage ‐gated Potassium Channel Kv1.2 Alleviates Nerve Injury‐induced Neuropathic Pain
AbstractVoltage ‐gated potassium channels (Kv) are important regulators of neuronal excitability for its role of regulating resting membrane potential and repolarization. Recent studies show that Kv channels participate in neuropathic pain, but the detailed underlying mechanisms are far from being clear. In the c urrent study, we used siRNA, miR‐137 agomir and antagomir to regulate the expression of Kv1.2 in spinal cord and dorsal root ganglia (DRG) of naïve and chronic constriction injury (CCI) rats. Kv currents and neuron excitability in DRG neurons were examined by patch‐clamp whole‐cell recording to verify the...
Source: Journal of Neurochemistry - July 2, 2020 Category: Neuroscience Authors: Jingjing Zhang, Lina Rong, Jinping Shao, Yidan Zhang, Yaping Liu, Sen Zhao, Lei Li, Wenli Yu, Mengya Zhang, Xiuhua Ren, Qingzan Zhao, Changlian Zhu, Huan Luo, Weidong Zang, Jing Cao Tags: ORIGINAL ARTICLE Source Type: research

The neuronal potassium current IA is a potential target for pain during chronic inflammation
In this study, we sought to determine how peripheral inflammation caused by complete Freund's adjuvant (CFA) alters the fast sodium (INa), L-type calcium (ICaL), and potassium (IK) currents in primary afferent fibers to increase nociception. In our model, intraplantar administration of CFA induced mechanical allodynia and thermal hyperalgesia at day 14 post-injection. Using whole-cell patch-clamp recording in dissociated small (C), medium (A δ), and large-sized (Aβ) rat dorsal root ganglion (DRG) neurons, we found that CFA prolonged the AP duration and increased the amplitude of the tetrodotoxin-resistant (TTX-r) INa in ...
Source: Physiological Reports - August 18, 2021 Category: Physiology Authors: Michael Biet, Marc ‐André Dansereau, Philippe Sarret, Robert Dumaine Tags: ORIGINAL ARTICLE Source Type: research

Diclofenac Potassium Alone Versus Diclofenac Potassium with Hyoscine-N-butyl Bromide (HBB) in Reduction of Pain in Women Undergoing Office Hysteroscopy: A Double Blind Randomized, Placebo-Controlled Trial
ConclusionThe combination of diclofenac potassium and HBB helps a lot in decreasing the pain and discomfort during and after performing office hysteroscopy but with more gastric side effects.
Source: The Journal of Obstetrics and Gynecology of India - April 13, 2022 Category: OBGYN Source Type: research

GSE208766 Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain
In this study, single-cell RNA sequencing analysis indicated that the expression of Kir4.1 and Methyl-CpG-binding protein 2 (MeCP2) were both decreased in spinal astrocytes after chronic constriction injury (CCI) in a mouse model. Conditional knockout of the Kir4.1 channel in spinal astrocytes led to hyperalgesia; and overexpression of the Kir4.1 channel in spinal cord relieved CCI-induced hyperalgesia. Expression of spinal Kir4.1 after CCI was regulated by MeCP2. Electrophysiological recording in spinal slices showed that knockdown of Kir4.1 significantly regulated the excitability of astrocytes and then functionally chan...
Source: GEO: Gene Expression Omnibus - July 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain
Brain Behav Immun. 2022 Aug 26:S0889-1591(22)00350-6. doi: 10.1016/j.bbi.2022.08.010. Online ahead of print.ABSTRACTThe spinal N-methyl-D-aspartate receptor (NMDAR), particularly their subtypes NR2A and NR2B, plays pivotal roles in neuropathic and inflammatory pain. However, the roles of NR2A and NR2B in orofacial pain and the exact molecular and cellular mechanisms mediating nervous system sensitization are still poorly understood. Here, we exhaustively assessed the regulatory effect of NMDAR in mediating peripheral and central sensitization in orofacial neuropathic pain. Von-Frey filament tests showed that the inferior a...
Source: Brain, Behavior, and Immunity - August 29, 2022 Category: Neurology Authors: Yan-Yan Zhang Fei Liu Zhong-Han Fang Yue-Ling Li Hong-Lin Liao Qin-Xuan Song Cheng Zhou Jie-Fei Shen Source Type: research

Combinations of Classical and Non-Classical Voltage Dependent Potassium Channel Openers Suppress Nociceptor Discharge and Reverse Chronic Pain Signs in a Rat Model of Gulf War Illness
Neurotoxicology. 2022 Oct 7:S0161-813X(22)00158-9. doi: 10.1016/j.neuro.2022.10.003. Online ahead of print.ABSTRACTIn a companion paper we examined whether combinations of Kv7 channel openers (Retigabine and Diclofenac; RET, DIC) could be effective modifiers of deep tissue nociceptor activity; and whether such combinations could then be optimized for use as safe analgesics for pain-like signs that developed in a rat model of GWI (Gulf War Illness) pain. In the present report, we examined the combinations of Retigabine/Meclofenamate (RET/MEC) and Meclofenamate/Diclofenac (MEC/DIC). Voltage clamp experiments were performed o...
Source: Neurotoxicology - October 10, 2022 Category: Neurology Authors: B Y Cooper T J Nutter L D Flunker C M Bowers Source Type: research

Case report: Pain in anti-DPPX encephalitis
Encephalitis due to antibodies targeting dipeptidyl-peptidase-like protein 6 (DPPX), a potassium channel subunit, is rare. The illness is typically characterized by a triad of weight loss, CNS hyperexcitability and cognitive symptoms, but recent reports suggest that the clinical picture may be more heterogeneous. Here, we describe the case of a 63-year-old female who was admitted to the hospital with severe extremity pain, which had been preceded by diarrhea and weight loss. She later developed cognitive changes, and her general condition rapidly deteriorated. Extensive workup did not reveal gastrointestinal illness or und...
Source: Frontiers in Neurology - December 14, 2022 Category: Neurology Source Type: research

Impact of Genetic Variants on Postoperative Pain and Fentanyl Dose Requirement in Patients Undergoing Major Breast Surgery: A Candidate Gene Association Study
CONCLUSIONS: The SNP opioid receptor mu-1 (OPRM1) (rs1799971) was associated with higher postoperative fentanyl requirement in South Indian patients undergoing major breast surgery. Twenty-four hour postoperative pain scores were higher in catechol-O-methyl transferase (COMT) (rs4680) carriers and lower in ATP binding cassette subfamily B member 1 (ABCB1) (rs1045642) carriers, whereas time for first analgesic was lower in potassium channel subunit 1 (KCNS1) (rs734784) carriers. However, these exploratory findings must be confirmed in a larger study.PMID:36538471 | DOI:10.1213/ANE.0000000000006330
Source: Anesthesia and Analgesia - December 20, 2022 Category: Anesthesiology Authors: Shathish Kumar Ramasamy Kesavan Sarath Chandra Sistla Prasanth Penumadu Harivenkatesh Natarajan Sreekumaran Nair Uppugunduri S Chakradhara Rao Vasuki Venkatesan Pankaj Kundra Source Type: research