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Long-term consumption of capsicum annum (chilli pepper) and capsaicin diets suppresses pain perception and improves social behaviour of CD-1 mice
Nutrition&Food Science, Ahead of Print. Purpose Chilli pepper (Capsicum annum), an extensively cultivated vegetable, is commonly used to spice many dishes prepared in several parts of the world. It contains capsaicinoids. The most active amongst these capsaicinoids is capsaicin (8-methyl-N-vanillyl-6-nonenamide), which is neurogenic and so may affect nervous function. Therefore, the purpose of this paper is to investigate the effects of long-term consumption of chilli pepper and capsaicin diets on pain and social behaviour in CD-1 Swiss white mice. Design/methodology/approach In total, 30 male mice were randomly assign...
Source: Nutrition and Food Science - September 28, 2018 Category: Nutrition Source Type: research

Amanda ’ s spectacular Wheat Belly success
Amanda began the process overweight, depressed, struggling with energy, muscle and joint pains, pre-diabetic, hypertensive, and with polycystic ovary syndrome, reliant on numerous medications even in her 20s and early 30s. As you can see now, after starting with the Wheat Belly 10-Day Grain Detox, she is now slender and free of ALL her health problems and off ALL her medications. “The pic on the left is me in my 20’s, 27 to be exact. This was before I ever started my journey. “That smile was masking physical and emotional pain, suicidal ideation, PCOS, depression, hypothyroidism, ADD symptoms, fibromyalgia s...
Source: Wheat Belly Blog - October 23, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates blood pressure diabetes fibromyalgia grain-free grains hypertension Inflammation joint pain polycystic ovary pre-diabetes pros undoctored Weight Loss wheat belly Source Type: blogs

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes
Conclusion: These data demonstrate for the first time that Arg supplementation increases mitochondrial activity and decreases oxidative stress in children with SCD and VOE. Our prior study showed that complex V inhibition leads to increased mitochondrial oxidant production in platelets from SCD patients. The improvement in complex V function & decreased oxidative markers observed with Arg treatment are consistent with Arg-induced decrease in mitochondrial oxidant generation. However, Arg treatment potentially regulates other oxidant sources and could decrease overall oxidative stress in SCD patients. Arg therapy has be...
Source: Blood - November 21, 2018 Category: Hematology Authors: Shiva, S., Brown, L. A., Wang, Y., Dampier, C., Watt, A., Tripathi, V., Bhutta, A., Kumari, P., Figueroa, J., Zmitrovich, A., Morris, C. R. Tags: 114. Hemoglobinopathies, Excluding Thalassemia Clinical: Novel or Improved Approaches To Treating Sickle Cell Disease Source Type: research

Recurrent Abdominal Pain in Children: Is Colonoscopy Indicated?
Recurrent abdominal pain (RAP) in children is common, with most functional in origin. Colonoscopy has sometimes been performed to exclude pathology but its role is unclear. Our aim therefore was to assess the diagnostic yield and role of colonoscopy in these children. Retrospective review of consecutive colonoscopies in a tertiary pediatric hospital between November 2011 and October 2015 was undertaken. Only those with RAP as an indication for procedure were included. Chart review of patients with pain was undertaken to ensure they fulfilled Rome IV criteria. Patient demographics, indication for procedure, and adjunct prep...
Source: Journal of Pediatric Gastroenterology and Nutrition - January 24, 2019 Category: Gastroenterology Tags: Short Communication: Gastroenterology Source Type: research

A Rare Cause of Postprandial Pain
​BY DHIMITRI A. NIKOLLA, DO; BRENDAN A. MICCIO; MELODY L. MILLIRON; & BRETT FOREHAND, MD, PHDA 49-year-old woman with a past medical history of chronic obstructive pulmonary disease presented to the emergency department with epigastric pain. She said the pain radiated to her chest and had been intermittent for six months, but it had been progressively worsening over the previous three weeks. Her pain was exacerbated by eating, and was associated with early satiety and nausea. She complained of a 30-pound weight loss over the preceding three months.Her vital signs included a blood pressure of 116/80 mm Hg, a heart rat...
Source: The Case Files - June 12, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Liraglutide after diet-induced weight loss for pain and weight control in knee osteoarthritis: a randomized controlled trial
ConclusionsIn patients with KOA and overweight/obesity liraglutide added after an 8-wk pre –random assignment diet induced a significant weight loss at>52 wk but did not reduce knee pain compared to placebo. This trial was registered atclinicaltrials.gov as NCT02905864.
Source: American Journal of Clinical Nutrition - January 20, 2021 Category: Nutrition Source Type: research

IJERPH, Vol. 18, Pages 7807: Temporomandibular Myofascial Pain Syndrome —Aetiology and Biopsychosocial Modulation. A Narrative Review
IJERPH, Vol. 18, Pages 7807: Temporomandibular Myofascial Pain Syndrome—Aetiology and Biopsychosocial Modulation. A Narrative Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18157807 Authors: Paulina Golanska Klara Saczuk Monika Domarecka Joanna Kuć Monika Lukomska-Szymanska This review elaborates on the aetiology, diagnosis, and treatment of temporomandibular (TMD) myofascial pain syndrome (MPS) regulated by psychosocial factors. MPS impairs functioning in society due to the accompanying pain. Directed and self-directed biopsychosocial profile modulation may b...
Source: International Journal of Environmental Research and Public Health - July 23, 2021 Category: Environmental Health Authors: Paulina Golanska Klara Saczuk Monika Domarecka Joanna Ku ć Monika Lukomska-Szymanska Tags: Review Source Type: research

Management of acute pain
Acute pain relief continues to be suboptimal for many patients. The efficacy of a postoperative analgesic strategy must take a holistic view, allowing timely return of patient function and integration with other recovery pathways such as physiotherapy and nutrition. Acute postoperative pain can hinder recovery due to limited mobility and may lead to a range of complications, increasing patient morbidity and mortality. Timely and effective management of acute pain is therefore imperative. An acute pain service (APS) is able to assist in the management of complex patients and those with specific invasive analgesic interventions.
Source: Surgery (Medicine Publishing) - April 30, 2022 Category: Surgery Authors: Eid Hussien, David Hay Tags: Perioperative management -- I Source Type: research

Collagen peptide supplementation for pain and function: is it effective?
Purpose of review Connective tissue injuries are prevalent in active and aging populations, leading to chronic pain and decreased function. Turnover of this tissue is not well understood, especially as it relates to aging and injury. Supplementation of collagen peptides has been shown to improve connective tissue recovery and pain through increased collagen production. Recent findings Collagen peptide supplementation improves pain and function, and upregulates metabolic pathways associated with muscle and tendon growth. Literature from the past 12–18 months supports that these pathways are also involved with...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - October 8, 2022 Category: Nutrition Tags: NUTRITION AND PHYSIOLOGICAL FUNCTION: Edited by Labros S. Sidossis and Carla Prado Source Type: research

Clinical Presentation of Acute Gastroenteritis in Children With Functional Abdominal Pain Disorders
ABSTRACT: Visceral hypersensitivity and abnormal coping are common in children with functional abdominal pain disorders (FAPDs). Thus, it would be expected that children with visceral hypersensitivity would report more pain if their gut is acutely inflamed. The aim of the study was to compare clinical symptoms and somatization of children with and without FAPDs at time of an episode of acute gastroenteritis. Seventy children with acute gastroenteritis and their parents completed the Rome III Diagnostic Questionnaire for Pediatric Functional GI Disorders and the Children's Somatization Inventory. Twenty-one percent of child...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 26, 2017 Category: Gastroenterology Tags: Short Communication: Gastroenterology Source Type: research

Initial Pain Management in Pediatric Acute Pancreatitis: Opioid Versus Non-opioid
Nearly all patients with acute pancreatitis (AP) experience some degree of abdominal pain that is severe enough to prompt medical evaluation and necessitate analgesia. Effective analgesia is a priority in caring for such patients. Despite its importance, strategies for pain management in AP have been poorly studied, particularly in the field of pediatrics. Presently, no published data examine the management of pain because of AP in children at the time of initial presentation. Management approaches are often extrapolated from adult practice and based on anecdotal experience in the absence of objective data. The aim of our ...
Source: Journal of Pediatric Gastroenterology and Nutrition - January 23, 2018 Category: Gastroenterology Tags: Short Communication: Pancreatology Source Type: research

Exposure to opiates in male adolescent rats alters pain perception in the male offspring
During the past decades, the use/misuse of opioids has increased dramatically among adolescent population. It is now well acknowledged that various morphological and physiological changes occur in the brain during adolescence. During this critical period, brain development and maturation could be affected by several factors including stress, drug abuse, nutritional status, etc. Although studies on transgenerational effects of substances such as alcohol, nicotine, and cocaine have focused on both paternal and maternal drug exposure, most reports on transgenerational effects of morphine are restricted to maternal exposure. T...
Source: Behavioural Pharmacology - March 15, 2018 Category: Drugs & Pharmacology Tags: Short Report Source Type: research

Randomized Controlled Clinical Trial on Value of Domperidone in Functional Abdominal Pain in Children
Conclusions: Domperidone may be a safe and effective therapeutic modality to achieve a lasting remission of symptoms in children with AP-FGIDs.
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2018 Category: Gastroenterology Tags: Clinical Trials: Gastroenterology Source Type: research

Recurrent Abdominal Pain in Children: Summary Evidence From 3 Systematic Reviews of Treatment Effectiveness
Conclusions: Overall the evidence base for treatment decisions is poor. These data suggest that probiotics, CBT, and hypnotherapy could be considered as part of holistic management of children with RAP. The evidence regarding relative effectiveness of different strains of probiotics is currently insufficient to guide clinical practice. The lack of evidence of effectiveness for any drug suggests that there is little justification for their use outside of well-conducted clinical trials. There is an urgent need for high-quality RCTs to provide evidence to guide management of this common condition.
Source: Journal of Pediatric Gastroenterology and Nutrition - June 26, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Dietary correlates of chronic widespread pain in Meru, Kenya
Chronic pain is one of the most common and disabling medical conditions worldwide [1]. Data from the World Health Organization suggest that across 17 developed and developing countries, the population attributable risk for “yearly days out of role” was significantly higher for chronic pain than that of 19 other health conditions assessed [2]. Low- and middle-income countries (LMICs) could be disproportionately affected by chronic pain because of differences in exposures and treatment options available.
Source: Nutrition - February 5, 2018 Category: Nutrition Authors: Kathleen F. Holton, Peter K. Ndege, Daniel J. Clauw Tags: Brief report Source Type: research