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Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Troubleshooting dioxins stack emissions in an industrial waste gas incinerator
In this study, monitoring campaign of International Toxic Equivalents for dioxins and furans (I-TEQDF), was carried out at pharmaceutical industrial waste incinerator to find a correlation between combustion parameters and feed composition with potential emission. Principal Component Analysis (PCA) shows that high values of dioxin emission correlate with short residence time of the flue gas in the furnace as well as low oxygen concentration. These operating conditions were further investigated, using COMSOL Computational Fluid Dynamics (CFD) simulation to calculate the temperature profiles along the furnace. The results su...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Amiram Bar Or Roberto Palazzolo Amir Kaplan Smadar Attia Nitsa Haikin David Katoshevski Source Type: research
Promoting short-chain fatty acids production from sewage sludge via acidogenic fermentation: Optimized operation factors and iron-based persulfate activation system
Chemosphere. 2023 Sep 13:140148. doi: 10.1016/j.chemosphere.2023.140148. Online ahead of print.ABSTRACTPromoting short-chain fatty acids (SCFAs) production and ensuring the stability of SCFAs-producing process are becoming the two major issues for popularizing the acidogenic fermentation (AF). The key controlling operating and influencing factors during anaerobic fermentation process were thoroughly reviewed to facilitate better process performance prediction and to optimize the process control of SCFAs promotion. The wide utilization of iron salt flocculants during wastewater treatment could result in iron accumulating in...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Faxin Liu Wen Cheng Jianping Xu Min Wang Tian Wan Jiehui Ren Dong Li Qiqi Xie Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Ferritin was involved in interleukin-17A enhanced osteogenesis through autophagy activation
In conclusion, IL-17A induced ferritin expression in osteoblasts, which further enhanced osteogenic differentiation via autophagy activation. These findings may provide further insight into the role of IL-17A in osteoblast differentiation and demonstrate ferritin as a potential target in modulating alveolar bone homeostasis.PMID:37713787 | DOI:10.1016/j.intimp.2023.110916
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Wenlin Yuan Yuting Yang Yingming Wei Xufei Yu Jiaqi Bao Jiahui Zhong Zhongxiu Wang Lili Chen Source Type: research
Network pharmacology and molecular docking to explore the mechanism of Sheng Xue Bao mixture against iron deficiency anemia
Medicine (Baltimore). 2023 Sep 15;102(37):e35012. doi: 10.1097/MD.0000000000035012.ABSTRACTBased on network pharmacology and molecular docking, we investigated the mechanism of action of Sheng Xue Bao mixture (SXBM) in treating iron deficiency anemia (IDA). We screened the HERB and traditional Chinese medicine systems pharmacology database and analysis platform databases to identify the active ingredients and targets of SXBM. The targets associated with "iron deficiency anemia" were collected from GeneCards, TTD, and OMIM databases. A component-target interaction network was constructed using Cytoscape 3.8.2. The protein-p...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Yun Wang Huang Qinqin Haixia Wang Hongxu Zhang Xinhua Zhang Weiguo Liu Zhenhua Xiang Yuming Gu Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Ferrous disulfide and iron nitride sites on hydrochar to enhance synergistic adsorption and reduction of hexavalent chromium
This study shows that Fe3-SNHC is a promising and environment-friendly material for Cr(VI) to remove it from wastewater.PMID:37714497 | DOI:10.1016/j.biortech.2023.129770
Source: Bioresource Technology - September 15, 2023 Category: Biotechnology Authors: Yuxin Liu Tianye Wang Ningning Song Quanying Wang Ying Zeng Shaoqing Zhang Hongwen Yu Source Type: research
Troubleshooting dioxins stack emissions in an industrial waste gas incinerator
In this study, monitoring campaign of International Toxic Equivalents for dioxins and furans (I-TEQDF), was carried out at pharmaceutical industrial waste incinerator to find a correlation between combustion parameters and feed composition with potential emission. Principal Component Analysis (PCA) shows that high values of dioxin emission correlate with short residence time of the flue gas in the furnace as well as low oxygen concentration. These operating conditions were further investigated, using COMSOL Computational Fluid Dynamics (CFD) simulation to calculate the temperature profiles along the furnace. The results su...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Amiram Bar Or Roberto Palazzolo Amir Kaplan Smadar Attia Nitsa Haikin David Katoshevski Source Type: research
Promoting short-chain fatty acids production from sewage sludge via acidogenic fermentation: Optimized operation factors and iron-based persulfate activation system
Chemosphere. 2023 Sep 13:140148. doi: 10.1016/j.chemosphere.2023.140148. Online ahead of print.ABSTRACTPromoting short-chain fatty acids (SCFAs) production and ensuring the stability of SCFAs-producing process are becoming the two major issues for popularizing the acidogenic fermentation (AF). The key controlling operating and influencing factors during anaerobic fermentation process were thoroughly reviewed to facilitate better process performance prediction and to optimize the process control of SCFAs promotion. The wide utilization of iron salt flocculants during wastewater treatment could result in iron accumulating in...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Faxin Liu Wen Cheng Jianping Xu Min Wang Tian Wan Jiehui Ren Dong Li Qiqi Xie Source Type: research
< em > Erchen < /em > Decoction improves iron homeostasis in mice with non-alcoholic fatty liver disease by regulating iron transport capacity in the spleen
CONCLUSION: Erchen Decoction can alleviate high-fat diet-induced iron metabolism disorder by improving the iron ion transport ability of the spleen cells to delay the progression of NAFLD.PMID:37712264 | PMC:PMC10505571 | DOI:10.12122/j.issn.1673-4254.2023.08.04
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: G Deng H Jia Y Li J Li C Wu H Shi M Qin J Zhao C Liu Y Liao L Gao Source Type: research
A comprehensive health risk assessment associated with bioaccumulation of heavy metals and nutrients in selected macrophytes of Loktak Lake, Manipur, India
Environ Sci Pollut Res Int. 2023 Sep 15. doi: 10.1007/s11356-023-29606-2. Online ahead of print.ABSTRACTThe Loktak Lake, a Ramsar site in Northeast India, is known for its rich biodiversity that includes a variety of macrophyte species, most of which have not been studied for their phytoremediation capacities and potential toxicity via consumption of the edible species. Therefore, a comprehensive assessment was conducted to evaluate the accumulation of selected heavy metals and nutrients in 10 dominant macrophyte species growing in Loktak Lake and to assess the potential health risks associated with consumption of the edib...
Source: Environmental Science and Pollution Research International - September 15, 2023 Category: Environmental Health Authors: Ranu Jajo Laishram Tensubam Basanta Singh Wazir Alam Source Type: research
Electron Transfer Beyond the Outer Membrane: Putting Electrons to Rest
Annu Rev Microbiol. 2023 Sep 15;77:517-539. doi: 10.1146/annurev-micro-032221-023725.ABSTRACTExtracellular electron transfer (EET) is the physiological process that enables the reduction or oxidation of molecules and minerals beyond the surface of a microbial cell. The first bacteria characterized with this capability were Shewanella and Geobacter, both reported to couple their growth to the reduction of iron or manganese oxide minerals located extracellularly. A key difference between EET and nearly every other respiratory activity on Earth is the need to transfer electrons beyond the cell membrane. The past decade has re...
Source: Annual Review of Microbiology - September 15, 2023 Category: Microbiology Authors: J A Gralnick D R Bond Source Type: research
