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Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease
Neurobiol Aging. 2023 Aug 9;132:24-35. doi: 10.1016/j.neurobiolaging.2023.08.001. Online ahead of print.ABSTRACTMultiple neuropathological events are involved in Alzheimer's disease (AD). The current study investigated the concurrence of neurodegeneration, increased iron content, atrophy, and demyelination in AD. Quantitative multiparameter magnetic resonance imaging (MRI) maps providing neuroimaging biomarkers for myelination and iron content along with synaptic density measurements using [18F] UCB-H PET were acquired in 24 AD and 19 Healthy controls (19 males). The whole brain voxel-wise group comparison revealed demyeli...
Source: Neurobiology of Aging - September 17, 2023 Category: Geriatrics Authors: Soodeh Moallemian Eric Salmon Mohamed Ali Bahri Nikita Beliy Emma Delhaye Evelyne Balteau Christian Degueldre Christophe Phillips Christine Bastin Source Type: research
Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease
Vitam Horm. 2023;123:249-284. doi: 10.1016/bs.vh.2023.03.001. Epub 2023 Mar 30.ABSTRACTThe peptide hormone hepcidin is central to the regulation of iron metabolism, influencing the movement of iron into the circulation and determining total body iron stores. Its effect on a cellular level involves binding ferroportin, the main iron export protein, preventing iron egress and leading to iron sequestration within ferroportin-expressing cells. Hepcidin expression is enhanced by iron loading and inflammation and suppressed by erythropoietic stimulation. Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Yelena Z Ginzburg Source Type: research
Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway
In conclusion, brevilin A protected mice against OA via suppressing inflammatory response and ferroptosis by regulating SIRT1/Nrf2/GPX4 signaling.PMID:37717314 | DOI:10.1016/j.intimp.2023.110924
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Qing Ruan Cuijie Wang Yunfeng Zhang Jiayang Sun Source Type: research
Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin
In this study, folic acid (FA)-modified layered double hydroxide loaded with simvastatin (SIM), a ferroptosis drug, was used to prepare a novel ferroptosis nanodrug (FA-LDH@SIM). The prepared nanodrug improved the therapeutic effect of SIM on glioma. Compared with free SIM, FA-LDH@SIM showed greater cytotoxicity, significantly inhibited glioma cell proliferation, and significantly inhibited glioma invasion and migration ability. Furthermore, SIM could induce changes in certain ferroptosis indicators, including increased intracellular LPO, ROS and MDA level, decreased GSH production, increased divalent iron level, and chang...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Wei Peng Yufeng Qian Xuchen Qi Source Type: research
Ratiometrically electrochemical and colorimetric dual-mode detection of glyphosate based on 2D Cu-TCPP(Fe) NSs
Talanta. 2023 Sep 13;267:125207. doi: 10.1016/j.talanta.2023.125207. Online ahead of print.ABSTRACTIn this work, a dual-signal output sensor was developed for the ratiometrically electrochemical and colorimetric detection of glyphosate (GLYP) based on the duplex nature of 2D Cu-TCPP(Fe) nanosheets (2D Cu-TCPP(Fe) NSs). Cu active center sites in 2D Cu-TCPP(Fe) NSs could transform into CuCl for signal amplification in the presence of chloride ions (Cl-), which dropped dramatically upon GLPY addition due to the strong interaction between GLYP and cuprous ion triggering the competitive reaction with the conversion of CuCl into...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Fan Zhao Dongqing Guo Xuan Tang Jingyue Lan Jing Chen Source Type: research
Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease
Neurobiol Aging. 2023 Aug 9;132:24-35. doi: 10.1016/j.neurobiolaging.2023.08.001. Online ahead of print.ABSTRACTMultiple neuropathological events are involved in Alzheimer's disease (AD). The current study investigated the concurrence of neurodegeneration, increased iron content, atrophy, and demyelination in AD. Quantitative multiparameter magnetic resonance imaging (MRI) maps providing neuroimaging biomarkers for myelination and iron content along with synaptic density measurements using [18F] UCB-H PET were acquired in 24 AD and 19 Healthy controls (19 males). The whole brain voxel-wise group comparison revealed demyeli...
Source: Neurobiology of Aging - September 17, 2023 Category: Geriatrics Authors: Soodeh Moallemian Eric Salmon Mohamed Ali Bahri Nikita Beliy Emma Delhaye Evelyne Balteau Christian Degueldre Christophe Phillips Christine Bastin Source Type: research
Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease
Vitam Horm. 2023;123:249-284. doi: 10.1016/bs.vh.2023.03.001. Epub 2023 Mar 30.ABSTRACTThe peptide hormone hepcidin is central to the regulation of iron metabolism, influencing the movement of iron into the circulation and determining total body iron stores. Its effect on a cellular level involves binding ferroportin, the main iron export protein, preventing iron egress and leading to iron sequestration within ferroportin-expressing cells. Hepcidin expression is enhanced by iron loading and inflammation and suppressed by erythropoietic stimulation. Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Yelena Z Ginzburg Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Hydroxyl radical generations form the physiologically relevant Fenton-like reactions
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00637-8. doi: 10.1016/j.freeradbiomed.2023.09.013. Online ahead of print.ABSTRACTIron(II) species can participate in the Fenton and Fenton-like reactions to generate the hydroxyl radical that can oxidatively damage biomolecules and induce oxidative stress in biological systems. Many diseases, including neurodegeneration, cardiovascular disease and cancer, are associated with oxidative stress. However, it is proposed recently that hydroxyl radical would not be generated from the Fenton reaction under physiological conditions and thus would not cause oxidative stress in biologic...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Zhongwei Zhao Source Type: research
Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model
Neurotoxicology. 2023 Sep 15:S0161-813X(23)00122-5. doi: 10.1016/j.neuro.2023.09.006. Online ahead of print.ABSTRACTMethamphetamine (METH) has been established to selectively target and impair dopaminergic neurons through multiple pathways. Ferroptosis is a unique form of non-apoptotic cell death driven by cellular iron accumulation-induced lipid peroxidation. Nonetheless, it remains unclear whether METH can induce ferroptosis. In the present study, we sought to assess alterations in iron levels after chronic METH exposure and reveal the modulatory role of iron on METH-induced pathologies. Importantly, we demonstrated that...
Source: Neurotoxicology - September 17, 2023 Category: Neurology Authors: Shanshan Hu Xiaorong Huang Jian Huang Ying Qian Yingbiao Tian Ye Xiao Xiaolan Qi Xiaoxian Zhou Zhusheng Yang Zehui Chen Source Type: research
Ultrastructural characteristics of the accumulation of iron nanoparticles in the intestine of Cyprinus carpio (Linnaeus, 1758) under aquaculture
Ecotoxicol Environ Saf. 2023 Sep 15;264:115477. doi: 10.1016/j.ecoenv.2023.115477. Online ahead of print.ABSTRACTDuring the development of nanotechnology, the production of many substances containing nanoparticles leads to the release of various nanoparticles into the environment, including the water ecosystem. The main goal of the current research was to study the ultrastructural characteristics of the entry and bioaccumulation of Fe3O4 nanoparticles in the small intestine of Cyprinus carpio (Linnaeus, 1758), as well as the pathomorphological changes in the fish organism. Two different doses (10 and 100 mg) of Fe3O4 nanop...
Source: Ecotoxicology and Environmental Safety - September 17, 2023 Category: Environmental Health Authors: Aysel Hajiyeva Chingiz Mamedov Eldar Gasimov Fuad Rzayev Rovshan Khalilov Elham Ahmadian Aziz Eftehari William C Cho Source Type: research
Enhanced Adsorption of Hexavalent Chromium from Aqueous Solutions by Iron- manganese Modified Cedarwood Biochar: Synthesis, Performance, Mechanism, and Variables
Bull Environ Contam Toxicol. 2023 Sep 16;111(3):43. doi: 10.1007/s00128-023-03802-9.ABSTRACTThree modified biochar (Cunninghamia lanceolata) with iron and manganese elementals (FMBCs) were successfully prepared and used to remove hexavalent chromium (Cr(VI)) from aqueous solutions. The biochar before and after decoration were characterized by advanced instruments. The adsorption capacities of modified biochar in different Cr(VI) (20 mg·L- 1, 1 mg·L- 1) solutions were 4868.28 mg·kg- 1 and 300 mg·kg- 1. The Cr(VI) removal was highest at pH 2. The possible adsorption was considered to be ion exchange adsorption, chemisorp...
Source: Bulletin of Environmental Contamination and Toxicology - September 16, 2023 Category: Environmental Health Authors: Jizhuang Chu Shuhan Xin Yihang He Xin Gao Xin Zhou Yingqi Zhang Xinxin Liu Xinru Zhang Shiliang Wang Source Type: research
School-based supplementation with iron-folic acid or multiple micronutrient tablets to address anemia among adolescents in Burkina Faso: a cluster-randomized trial
CONCLUSIONS: Results do not provide strong evidence that weekly IFA or daily MMS supplementation alone is effective, but supplementation may play a role in addressing adolescent anemia if combined with co-interventions. Additional research is required to determine the best strategy to address anemia.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT04657640 TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT04657640, registered December 8, 2020.PMID:37716443 | DOI:10.1016/j.ajcnut.2023.09.004
Source: Am J Clin Nutr - September 16, 2023 Category: Nutrition Authors: Ilana R Cliffer Ourohir é Millogo Yllassa Barry Idrissa Kouanda Guillaume Compaore Dongqing Wang Ali Sie Wafaie Fawzi Source Type: research
Associations of metal mixtures with thyroid function and potential interactions with iodine status: results from a cross-sectional study in MEWHC
Environ Sci Pollut Res Int. 2023 Sep 16. doi: 10.1007/s11356-023-29682-4. Online ahead of print.ABSTRACTFew studies are available on associations between metal mixture exposures and disrupted thyroid hormone homeostasis; particularly, the role of iodine status was ignored. Here, we aimed to explore the cross-sectional relationship of blood cell metals with thyroid homeostasis and explore the potential modifying effect of iodine status. Among 328 workers from the manganese-exposed workers healthy cohort (MEWHC), we detected thyroid function parameters: thyroid stimulating hormone (TSH), total triiodothyronine (TT3), free tr...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Xiaoting Ge Junxiu He Sencai Lin Yu Bao Yuan Zheng Hong Cheng Haiqing Cai Xiuming Feng Wenjun Yang Sihan Hu Lin Wang Qijing Liao Fei Wang Cahoqun Liu Xing Chen Yunfeng Zou Xiaobo Yang Source Type: research
