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Nutrition: Iron
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The health impacts of blood donation: a systematic review of donor and non-donor perceptions
DISCUSSION: Findings reinforce that lay perspectives on how donation impacts health are under-researched, and it is difficult to know how important these are in informing critical decisions about donation for donors and non-donors. We suggest that further research with donation-related health beliefs and experiences as the central focus is needed to provide insights to inform communications with donors and the public.PMID:37677092 | DOI:10.2450/BloodTransfus.494
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Rachel Thorpe Barbara Masser Sarah P Coundouris Melissa K Hyde Sarah P Kruse Tanya E Davison Source Type: research
T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1
Chemosphere. 2023 Sep 5:140087. doi: 10.1016/j.chemosphere.2023.140087. Online ahead of print.ABSTRACTT-2 toxin, a natural secondary sesquiterpenoid metabolite produced by numerous strains of Fusarium fungi, is prevalent in both contaminated food and the environment. T-2 toxin is known to be highly toxic to the cardiovascular system, but the precise mechanisms that lead to T-2 toxin-induced cardiotoxicity are not yet fully comprehended. Recent findings indicate that ferroptosis is a pivotal factor in cardiovascular damage and exhibits a strong correlation with the detrimental impacts of T-2 toxin. The present study was des...
Source: Chemosphere - September 7, 2023 Category: Chemistry Authors: Chi Wang Jun He Hong Jin Haixin Xiao Shuangqing Peng Jianwei Xie Li Zhang Jiabin Guo Source Type: research
Intricate link between siderophore secretion and drug efflux in < em > Mycobacterium tuberculosis < /em >
In this study, we show that M. tuberculosis mutants lacking components of the MmpS4-MmpL4 and MmpS5-MmpL5 systems are more susceptible to bedaquiline, clofazimine, and rifabutin, important drugs for treatment of drug-resistant TB. While genetic deletion experiments revealed similar functions of the MmpL4 and MmpL5 transporters in siderophore and drug secretion, complementation experiments indicated that the MmpS4-MmpL4 proteins alone are not sufficient to restore drug efflux in an M. tuberculosis mutant lacking both operons, in contrast to MmpS5-MmpL5. Importantly, an M. tuberculosis mutant lacking the recently discovered ...
Source: Antimicrobial Agents and Chemotherapy - September 7, 2023 Category: Microbiology Authors: Virginia Meikle Lei Zhang Michael Niederweis Source Type: research
Reductive soil disinfestation and Fe amendment improve soil microbial composition and Fritillaria production
In this study, the influences of iron mineral, RSD with different organic maters, as well as the combined effects of iron mineral and RSD on Fritillaria rhizosphere soil physicochemical properties, microbial communities, and Fritillaria production were investigated. The results revealed that the RSD treatments with potato peel significantly reduced the soil salinity and increased the soil pH, microbial activity, organic matter, and the contents of K and Ca. RSD with potato peel also significantly thrived of the beneficial microbes (Bacillus, Azotobacter, Microvirga, and Chaetomium), and down-regulated potential plant patho...
Source: Applied Microbiology and Biotechnology - September 7, 2023 Category: Microbiology Authors: Yue Yin Jun Zhao Pan Wang Siming You Yaoyu Zhou Jonathan W C Wong Huimin Deng Guilan Duan Yongguan Zhu Source Type: research
Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research
< em > Mesoterricola silvestris < /em > gen. nov., sp. nov., < em > Mesoterricola sediminis < /em > sp. nov., < em > Geothrix oryzae < /em > sp. nov., < em > Geothrix edaphica < /em > sp. nov., < em > Geothrix rubra < /em > sp. nov., and < em > Geothrix limicola < /em > sp. nov., six novel members of < em > Acidobacteriota < /em > isolated from soils
Int J Syst Evol Microbiol. 2023 Sep;73(9). doi: 10.1099/ijsem.0.006073.ABSTRACTForty-eight Acidobacteriota strains were isolated from soils and sediments in Japan. Among them, six representative strains, designated W79T, W786T, Red222T, Red802T, Red803T, and Red804T, were subjected to the taxonomic classification. These six strains are Gram-stain-negative, non-spore-forming, rod-shaped, and facultative anaerobic bacterium that can reduce ferric iron. Phylogenetic and phylogenomic trees based on 16S rRNA genes and multiple single-copy gene sequences showed that strains Red222T, Red802T, Red803T, and Red804T formed a cluster...
Source: International Journal of Systematic and Evolutionary Microbiology - September 7, 2023 Category: Microbiology Authors: Hideomi Itoh Yumi Sugisawa Kazumori Mise Zhenxing Xu Miyu Kuniyasu Natsumi Ushijima Keisuke Kawano Emiko Kobayashi Yutaka Shiratori Yoko Masuda Keishi Senoo Source Type: research
Rosiglitazone inhibits acyl-CoA synthetase long-chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury
This study aimed to investigate the role of ACSL4 in SBI via the ferroptosis pathway. Ninety male Sprague-Dawley rats were examined using a model of SBI. Subsequently, the inhibitory effect of rosiglitazone on ACSL4 was assessed via western blot, real-time polymerase chain reaction (PCR), immunofluorescence, fluoro-jade C staining, Perl's staining, ROS assay, and neurological scoring. The results showed that compared with the Sham group, the protein levels of ACSL4 and transferrin were significantly increased after SBI. Administration of rosiglitazone significantly reduced neuronal necrosis, iron deposition, brain water co...
Source: Clinical and Experimental Pharmacology and Physiology - September 7, 2023 Category: Drugs & Pharmacology Authors: Jinchao Shen Min Qian Muyao Wu Jiafeng Tang Yating Gong Jie Li Jinfen Ji Baoqi Dang Source Type: research
Multivalent iron-based magnetic porous biochar from peach gum polysaccharide as a heterogeneous Fenton catalyst for degradation of dye pollutants
Int J Biol Macromol. 2023 Sep 5:126753. doi: 10.1016/j.ijbiomac.2023.126753. Online ahead of print.ABSTRACTWater contamination caused by organic dyes has become a significant concern, and catalytic degradation of dye pollutants is an effective solution. However, developing an affordable, easy-to-prepare, high-catalytic-activity, and renewable catalyst has proved challenging. The current study addresses this issue by introducing an efficient heterogeneous Fenton catalyst, known as multivalent iron-based magnetic porous biochar (mFe-MPB). This catalyst comprises multiple iron species, such as Fe3O4, γ-Fe2O3, zero-valent Fe ...
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Baotao Huang Chen Yang Hai Zeng Li Zhou Source Type: research
< em > Mesoterricola silvestris < /em > gen. nov., sp. nov., < em > Mesoterricola sediminis < /em > sp. nov., < em > Geothrix oryzae < /em > sp. nov., < em > Geothrix edaphica < /em > sp. nov., < em > Geothrix rubra < /em > sp. nov., and < em > Geothrix limicola < /em > sp. nov., six novel members of < em > Acidobacteriota < /em > isolated from soils
Int J Syst Evol Microbiol. 2023 Sep;73(9). doi: 10.1099/ijsem.0.006073.ABSTRACTForty-eight Acidobacteriota strains were isolated from soils and sediments in Japan. Among them, six representative strains, designated W79T, W786T, Red222T, Red802T, Red803T, and Red804T, were subjected to the taxonomic classification. These six strains are Gram-stain-negative, non-spore-forming, rod-shaped, and facultative anaerobic bacterium that can reduce ferric iron. Phylogenetic and phylogenomic trees based on 16S rRNA genes and multiple single-copy gene sequences showed that strains Red222T, Red802T, Red803T, and Red804T formed a cluster...
Source: International Journal of Systematic and Evolutionary Microbiology - September 7, 2023 Category: Microbiology Authors: Hideomi Itoh Yumi Sugisawa Kazumori Mise Zhenxing Xu Miyu Kuniyasu Natsumi Ushijima Keisuke Kawano Emiko Kobayashi Yutaka Shiratori Yoko Masuda Keishi Senoo Source Type: research
T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1
Chemosphere. 2023 Sep 5:140087. doi: 10.1016/j.chemosphere.2023.140087. Online ahead of print.ABSTRACTT-2 toxin, a natural secondary sesquiterpenoid metabolite produced by numerous strains of Fusarium fungi, is prevalent in both contaminated food and the environment. T-2 toxin is known to be highly toxic to the cardiovascular system, but the precise mechanisms that lead to T-2 toxin-induced cardiotoxicity are not yet fully comprehended. Recent findings indicate that ferroptosis is a pivotal factor in cardiovascular damage and exhibits a strong correlation with the detrimental impacts of T-2 toxin. The present study was des...
Source: Chemosphere - September 7, 2023 Category: Chemistry Authors: Chi Wang Jun He Hong Jin Haixin Xiao Shuangqing Peng Jianwei Xie Li Zhang Jiabin Guo Source Type: research
Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease
CONCLUSIONS: This is the first report documenting that genes known to be involved in ferroptosis are differentially expressed in human skeletal muscle affected by PAD. Targeting ferroptosis may be a novel therapeutic strategy to reduce PAD myopathy.PMID:37675635 | DOI:10.1161/ATVBAHA.123.319518
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Lillian Tran Bowen Xie Edwyn Assaf Ricardo Ferrari Iraklis I Pipinos George P Casale Roberto Ivan Mota Alvidrez Simon Watkins Ulka Sachdev Source Type: research
The health impacts of blood donation: a systematic review of donor and non-donor perceptions
DISCUSSION: Findings reinforce that lay perspectives on how donation impacts health are under-researched, and it is difficult to know how important these are in informing critical decisions about donation for donors and non-donors. We suggest that further research with donation-related health beliefs and experiences as the central focus is needed to provide insights to inform communications with donors and the public.PMID:37677092 | DOI:10.2450/BloodTransfus.494
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Rachel Thorpe Barbara Masser Sarah P Coundouris Melissa K Hyde Sarah P Kruse Tanya E Davison Source Type: research
T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1
Chemosphere. 2023 Sep 5:140087. doi: 10.1016/j.chemosphere.2023.140087. Online ahead of print.ABSTRACTT-2 toxin, a natural secondary sesquiterpenoid metabolite produced by numerous strains of Fusarium fungi, is prevalent in both contaminated food and the environment. T-2 toxin is known to be highly toxic to the cardiovascular system, but the precise mechanisms that lead to T-2 toxin-induced cardiotoxicity are not yet fully comprehended. Recent findings indicate that ferroptosis is a pivotal factor in cardiovascular damage and exhibits a strong correlation with the detrimental impacts of T-2 toxin. The present study was des...
Source: Chemosphere - September 7, 2023 Category: Chemistry Authors: Chi Wang Jun He Hong Jin Haixin Xiao Shuangqing Peng Jianwei Xie Li Zhang Jiabin Guo Source Type: research
Multivalent iron-based magnetic porous biochar from peach gum polysaccharide as a heterogeneous Fenton catalyst for degradation of dye pollutants
Int J Biol Macromol. 2023 Sep 5:126753. doi: 10.1016/j.ijbiomac.2023.126753. Online ahead of print.ABSTRACTWater contamination caused by organic dyes has become a significant concern, and catalytic degradation of dye pollutants is an effective solution. However, developing an affordable, easy-to-prepare, high-catalytic-activity, and renewable catalyst has proved challenging. The current study addresses this issue by introducing an efficient heterogeneous Fenton catalyst, known as multivalent iron-based magnetic porous biochar (mFe-MPB). This catalyst comprises multiple iron species, such as Fe3O4, γ-Fe2O3, zero-valent Fe ...
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Baotao Huang Chen Yang Hai Zeng Li Zhou Source Type: research
Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes
In conclusion, our findings demonstrate that induction of adipocyte inflammation disrupts iron homeostasis, resulting in adipocyte iron overload.PMID:37677967 | DOI:10.1016/j.biopha.2023.115428
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: N úria Oliveras-Cañellas Jessica Latorre Elena Santos-Gonz ález Aina Lluch Francisco Ortega Jordi Mayneris-Perxachs Jos é-Manuel Fernández-Real Jos é María Moreno-Navarrete Source Type: research
