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Nutrition: Calcium
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High calcium concentrations reduce cellular excitability of mouse MNTB neurons
Brain Res. 2023 Sep 7:148568. doi: 10.1016/j.brainres.2023.148568. Online ahead of print.ABSTRACTCalcium, a universal intracellular signaling molecule, plays essential roles in neural functions. Historically, in most in vitro brain slice electrophysiology studies, the extracellular calcium concentration ([Ca2+]e) in artificial cerebrospinal fluid is of a wide range and typically higher than the physiological value. At high [Ca2+]e, synaptic transmission is generally enhanced. However, the effects and the underlying mechanisms of calcium on intrinsic neuronal properties are diverse. Using whole-cell patch clamp in acute bra...
Source: Brain Research - September 9, 2023 Category: Neurology Authors: Huimei Wang Yong Lu Source Type: research
Characterization of landfills solid waste in Muscat and estimation of their energy recovery
In this study, MSW from Muscat Governorate landfills is examined. The MSW samples were collected et al. Amerat and Barka landfills in 2020 in order to determine some of the importance of their physiochemical properties and the ratio of materials (food, plastic, and paper). It was found that approximately 50% of the weight of the disposed waste was recyclable. There were high levels of biodegradable organic material in MSW. In terms of moisture content, MSW ranged from 21.5 to 43.3%. Both the volatility and loss of ignition of MSW were high. It was found that the total oxide ratios ranged from 12.4 to 44.06%. The elemental ...
Source: Environmental Science and Pollution Research International - September 9, 2023 Category: Environmental Health Authors: Talal Etri Omaima Al Samsami Mahad Baawain Source Type: research
Encapsulation of Dicranopteris linearis extract using cellulose microparticles for antiulcer medication
Int J Biol Macromol. 2023 Sep 7:126795. doi: 10.1016/j.ijbiomac.2023.126795. Online ahead of print.ABSTRACTDicranopteris linearis (DL) is a fern in the Gleicheniaceae family, locally known as resam by the Malay community. It has numerous pharmacological benefits, with antiulcer and gastroprotective properties. Peptic ulcer is a chronic and recurring disease that significantly impacts morbidity and mortality, affecting nearly 20 % of the world's population. Despite the effectiveness of peptic ulcer drugs, there is no perfect treatment for the ailment. Encapsulation is an advanced technique that can treat peptic ulcers by in...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Anis Adilah Ahmad Khairul Farihan Kasim Subash C B Gopinath Periasamy Anbu Noor Soffalina Sofian Seng Source Type: research
Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling
J Cell Mol Med. 2023 Sep 8. doi: 10.1111/jcmm.17949. Online ahead of print.NO ABSTRACTPMID:37688368 | DOI:10.1111/jcmm.17949
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Hamish M Aitken-Buck Ei Phyo Khaing Regis R Lamberts Peter P Jones Source Type: research
Modulation of Oxidized Low-density Lipoprotein-Affected Macrophage Efferocytosis by Mitochondrial Calcium Uniporter in a Murine Model
CONCLUSIONS: In this study, we found that MCU inhibition modulated intracytoplasmic Ca2+ concentration, improved impaired Mø efferocytosis, and reduced ROS generation. Macrophage efferocytosis removed apoptotic cells and prevented the release of inflammatory factor and foam cell formation, and this can be a potential new therapeutic target for alleviating atherosclerosis.PMID:37689315 | DOI:10.1016/j.imlet.2023.09.003
Source: Immunology Letters - September 9, 2023 Category: Allergy & Immunology Authors: Na Lu Jun-Fan Zhu He-Fan Lv Hai-Peng Zhang Peng-le Wang Jing-Jing Yang Xian-Wei Wang Source Type: research
High calcium concentrations reduce cellular excitability of mouse MNTB neurons
Brain Res. 2023 Sep 7:148568. doi: 10.1016/j.brainres.2023.148568. Online ahead of print.ABSTRACTCalcium, a universal intracellular signaling molecule, plays essential roles in neural functions. Historically, in most in vitro brain slice electrophysiology studies, the extracellular calcium concentration ([Ca2+]e) in artificial cerebrospinal fluid is of a wide range and typically higher than the physiological value. At high [Ca2+]e, synaptic transmission is generally enhanced. However, the effects and the underlying mechanisms of calcium on intrinsic neuronal properties are diverse. Using whole-cell patch clamp in acute bra...
Source: Brain Research - September 9, 2023 Category: Neurology Authors: Huimei Wang Yong Lu Source Type: research
Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling
J Cell Mol Med. 2023 Sep 8. doi: 10.1111/jcmm.17949. Online ahead of print.NO ABSTRACTPMID:37688368 | DOI:10.1111/jcmm.17949
Source: J Cell Mol Med - September 9, 2023 Category: Molecular Biology Authors: Hamish M Aitken-Buck Ei Phyo Khaing Regis R Lamberts Peter P Jones Source Type: research
Modulation of Oxidized Low-density Lipoprotein-Affected Macrophage Efferocytosis by Mitochondrial Calcium Uniporter in a Murine Model
CONCLUSIONS: In this study, we found that MCU inhibition modulated intracytoplasmic Ca2+ concentration, improved impaired Mø efferocytosis, and reduced ROS generation. Macrophage efferocytosis removed apoptotic cells and prevented the release of inflammatory factor and foam cell formation, and this can be a potential new therapeutic target for alleviating atherosclerosis.PMID:37689315 | DOI:10.1016/j.imlet.2023.09.003
Source: Immunology Letters - September 9, 2023 Category: Allergy & Immunology Authors: Na Lu Jun-Fan Zhu He-Fan Lv Hai-Peng Zhang Peng-le Wang Jing-Jing Yang Xian-Wei Wang Source Type: research
Therapeutic Aspects of < em > Prunus cerasus < /em > Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction
This study evaluates the potential therapeutic effects of anthocyanin-rich Prunus cerasus (sour cherry) extract (PCE) on atherosclerosis-associated cardiac dysfunction, described by the impairment of the NO-PKG (nitric oxide-protein kinase G) pathway and the antioxidant capacity. Initially, a rabbit model of atherosclerotic cardiovascular disease was established by administering a cholesterol-rich diet, enabling the examination of the impact of 9 g/kg PCE on the pre-existing compromised cardiovascular condition. After that, the animals were divided into four groups for 12 weeks: the (1) untreated control group; (2) PCE-adm...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Reka Szekeres Daniel Priksz Rita Kiss Dana Diana Romanescu Mariann Bombicz Balazs Varga Rudolf Gesztelyi Anna Szilagyi Barbara Takacs Vera Tarjanyi Beata Pelles-Tasko Ildiko Forgacs Judit Remenyik Zoltan Szilvassy Bela Juhasz Source Type: research
Encapsulation of Dicranopteris linearis extract using cellulose microparticles for antiulcer medication
Int J Biol Macromol. 2023 Sep 7:126795. doi: 10.1016/j.ijbiomac.2023.126795. Online ahead of print.ABSTRACTDicranopteris linearis (DL) is a fern in the Gleicheniaceae family, locally known as resam by the Malay community. It has numerous pharmacological benefits, with antiulcer and gastroprotective properties. Peptic ulcer is a chronic and recurring disease that significantly impacts morbidity and mortality, affecting nearly 20 % of the world's population. Despite the effectiveness of peptic ulcer drugs, there is no perfect treatment for the ailment. Encapsulation is an advanced technique that can treat peptic ulcers by in...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Anis Adilah Ahmad Khairul Farihan Kasim Subash C B Gopinath Periasamy Anbu Noor Soffalina Sofian Seng Source Type: research
Aortic Wall Thickness as a Surrogate for Subclinical Atherosclerosis in Familial and Nonfamilial Hypercholesterolemia: Quantitative 3D Magnetic Resonance Imaging Study and Interrelations with Computed Tomography Calcium Scores, and Carotid Ultrasonography
J Clin Med. 2023 Aug 27;12(17):5589. doi: 10.3390/jcm12175589.ABSTRACTWe aimed to compare the extent of subclinical atherosclerosis in the ascending and descending aortas by measuring wall area and thickness using 3D cardiovascular magnetic resonance imaging (aAWAI and dAWAI) in patients with asymptomatic familial hypercholesterolemia (FH) and nonfamilial hypercholesterolemia (NFH). We also aimed to establish the interrelations of CMR parameters with other subclinical atherosclerosis measurements, such as calcium scores, obtained using computed tomography in coronary arteries (CCS) and ascending and descending aorta (TCSas...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Rafa ł Gałąska Dorota Kulawiak-Ga łąska Karolina Dorniak Aneta Str óżyk Agnieszka Sabisz Magdalena Chmara Bartosz Was ąg Agnieszka Mickiewicz Andrzej Rynkiewicz Marcin Fija łkowski Marcin Grucha ła Source Type: research
Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling
J Cell Mol Med. 2023 Sep 8. doi: 10.1111/jcmm.17949. Online ahead of print.NO ABSTRACTPMID:37688368 | DOI:10.1111/jcmm.17949
Source: J Cell Mol Med - September 9, 2023 Category: Molecular Biology Authors: Hamish M Aitken-Buck Ei Phyo Khaing Regis R Lamberts Peter P Jones Source Type: research
Biodegradable, UV-blocking, and antioxidant films from lignocellulosic fibers of spent coffee grounds
Int J Biol Macromol. 2023 Sep 7:126798. doi: 10.1016/j.ijbiomac.2023.126798. Online ahead of print.ABSTRACTPlastics are strong, flexible, and inexpensive and hence desirable for packaging. However, as they biodegrade very slowly, their waste remains a global burden and pollution, warranting a search for safer alternatives. Towards this end, residual fibers from biowaste, such as spent coffee grounds (SCGs), stand out for creating biodegradable packaging materials. Herein, lignocellulosic fibers from SCG were extracted, and various amounts (0.6, 0.8, 1.0, and 1.2 g) were solubilized using 68 % ZnCl2 and crosslinked with sal...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Sajal Bhattarai Srinivas Janaswamy Source Type: research
Sperm acrosomal released proteome reveals MDH and VDAC3 from mitochondria are involved in acrosome formation during spermatogenesis in Eriocheir sinensis
Gene. 2023 Sep 7:147784. doi: 10.1016/j.gene.2023.147784. Online ahead of print.ABSTRACTAcrosome is inextricably related to membranous organelles. The origin of acrosome is still controversial, one reason is that limited articles were reported about the proteomic analysis of the acrosome. Mitochondrial proteins were found exist in the acrosome, nevertheless, only limited attention has been paid to the function of mitochondrial proteins in the acrosome formation. Eriocheir sinensis sperm has a large acrosome, which makes it an ideal model to study acrosome formation. Here, we firstly compared the rate of acrosome reaction i...
Source: Gene - September 9, 2023 Category: Genetics & Stem Cells Authors: Chao Li Ruifang Yu Huan Liu Jiashan Qiao Fenghao Zhang Shumei Mu Mingshen Guo Han Zhang Yanqin Li Xianjiang Kang Source Type: research
Characterization of landfills solid waste in Muscat and estimation of their energy recovery
In this study, MSW from Muscat Governorate landfills is examined. The MSW samples were collected et al. Amerat and Barka landfills in 2020 in order to determine some of the importance of their physiochemical properties and the ratio of materials (food, plastic, and paper). It was found that approximately 50% of the weight of the disposed waste was recyclable. There were high levels of biodegradable organic material in MSW. In terms of moisture content, MSW ranged from 21.5 to 43.3%. Both the volatility and loss of ignition of MSW were high. It was found that the total oxide ratios ranged from 12.4 to 44.06%. The elemental ...
Source: Environmental Science and Pollution Research International - September 9, 2023 Category: Environmental Health Authors: Talal Etri Omaima Al Samsami Mahad Baawain Source Type: research
