Modulation of Oxidized Low-density Lipoprotein-Affected Macrophage Efferocytosis by Mitochondrial Calcium Uniporter in a Murine Model

CONCLUSIONS: In this study, we found that MCU inhibition modulated intracytoplasmic Ca2+ concentration, improved impaired Mø efferocytosis, and reduced ROS generation. Macrophage efferocytosis removed apoptotic cells and prevented the release of inflammatory factor and foam cell formation, and this can be a potential new therapeutic target for alleviating atherosclerosis.PMID:37689315 | DOI:10.1016/j.imlet.2023.09.003

Source: Immunology Letters - September 9, 2023 Category: Allergy & Immunology Authors: Na Lu Jun-Fan Zhu He-Fan Lv Hai-Peng Zhang Peng-le Wang Jing-Jing Yang Xian-Wei Wang Source Type: research