• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies
ConclusionIn male rodents, melatonin therapy was related to improved testicular histopathology, reproductive hormones, testis and body weights, and reduced levels of oxidative markers in testicular tissues of male rodents. Future meticulous studies are recommended to provide a robust scientific backbone for human applications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355293, identifier CRD42022355293.
Source: Frontiers in Endocrinology - August 28, 2023 Category: Endocrinology Source Type: research

Effect of Brachytherapy With External Beam Radiation Therapy Versus Brachytherapy Alone for Intermediate-Risk Prostate Cancer: NRG Oncology RTOG 0232 Randomized Clinical Trial
CONCLUSION: Compared with BT, COMBO did not improve FFP for prostate cancer but caused greater toxicity. BT alone can be considered as a standard treatment for men with intermediate-risk prostate cancer.PMID:37315297 | DOI:10.1200/JCO.22.01856
Source: Clinical Prostate Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Jeff M Michalski Kathryn A Winter Bradley R Prestidge Martin G Sanda Mahul Amin William S Bice Hiram A Gay Geoffrey S Ibbott Juanita M Crook Charles N Catton Adam Raben Walter Bosch David C Beyer Steven J Frank Michael A Papagikos Seth A Rosenthal H Josep Source Type: research

Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools
Curr Top Med Chem. 2023 May 15. doi: 10.2174/1568026623666230515154442. Online ahead of print.ABSTRACTThe radiolabeled tracers have been extensively utilized to access various physiological and pathological conditions non-invasively, such as cancers, inflammation, and organ-specific imaging. These tracers demonstrate and study tumor hypoxia in several malignancies. Hypoxia is commonly seen in solid tumors.Tumor Hypoxia is a non-physiological condition of reduced oxygen concentration in the tumor. Hypoxia is associated with adverse outcomes such as treatment resistance and metastases in solid tumors. Tumor hypoxia may resul...
Source: Current Topics in Medicinal Chemistry - May 16, 2023 Category: Chemistry Authors: Priya Saxena Sanjay Gambhir Manish Dixit Source Type: research

Biochemical outcomes and toxicities in young men with prostate cancer after permanent iodine-125 seed implantation: Prospective cohort study in 6662 patients
CONCLUSIONS: After PI, men <60 years achieved a comparable 5-year biochemical control rate and showed a lower incidence of several toxicities compared to men ≥60 years. This suggests that PI should be an excellent treatment option for men <60 years with prostate cancer.PMID:36599746 | DOI:10.1016/j.brachy.2022.12.001
Source: Cancer Control - January 4, 2023 Category: Cancer & Oncology Authors: Norihisa Katayama Atsunori Yorozu Takashi Kikuchi Satoshi Higashide Koji Masui Shinsuke Kojima Shiro Saito Source Type: research

Coexisting Papillary and Anaplastic Thyroid Cancer: Elucidating the Spectrum of Aggressive Behavior
CONCLUSIONS: Survival of patients with co-PTC/ATC is dependent on the presence of aggressive clinicopathologic features and lies within a spectrum between that of PTC and ATC. Adjuvant RAI and EBRT treatment may be beneficial, even after R0 resection.PMID:36224511 | DOI:10.1245/s10434-022-12553-6
Source: Ann Oncol - October 12, 2022 Category: Cancer & Oncology Authors: Jacques A Greenberg Maureen D Moore Jessica W Thiesmeyer Caitlin E Egan Yeon Joo Lee Paul Christos Rasa Zarnegar Toni Beninato Thomas J Fahey Iii Brendan M Finnerty Source Type: research

Is iodine-125 seed strand brachytherapy suitable for ureteral carcinoma?
CONCLUSION: UC can be safely and effectively treated by nephrostomy combined with ISS brachytherapy, a viable option for patients who cannot undergo or refuse surgical resection.PMID:36216664 | DOI:10.1016/j.urolonc.2022.08.009
Source: Urologic Oncology - October 10, 2022 Category: Urology & Nephrology Authors: Kaihao Xu Chuan Tian Yiming Liu Kunpeng Wu Dechao Jiao Xinwei Han Source Type: research

Well-Differentiated Thyroid Cancer: Who Should Get Postoperative Radiation?
CONCLUSIONS: Our data show that select patients who received PORT had improved locoregional recurrence-free probability; however, this did not translate into improved DSS and OS. At our institution, we recommend the use of PORT only in highly selected patients with locally advanced primary tumors who are deemed to have a high risk of central neck recurrence for which salvage surgery would result in unacceptable risk to the airway.PMID:35583688 | DOI:10.1245/s10434-022-11898-2
Source: Ann Oncol - May 18, 2022 Category: Cancer & Oncology Authors: Dauren Adilbay Avery Yuan Paul B Romesser Richard J Wong Jatin P Shah Ashok R Shaha Michael R Tuttle Snehal Patel Nancy Y Lee Ian Ganly Source Type: research

Recurrent Hurthle cell thyroid carcinoma does not preclude long-term survival: a case report and review of the literature
ConclusionFollicular and Hurthle cell thyroid carcinoma are known to potentially spread hematogenously to typical sites, such as lung or bones, however; unusual metastatic sites as presented in our case can also be observed. A search of the literature revealed only scattered reports on patients with multiple metastases in unusual locations. Furthermore, the observed long-term survival of our patient is contradictory to the existing data. As demonstrated, recurrent disease may appear years after the initial diagnosis, emphasizing the importance of consistent aftercare. Radioactive iodine therapy, extracorporeal radiation th...
Source: Journal of Medical Case Reports - August 11, 2021 Category: General Medicine Source Type: research

Efficacy and tolerance of salvage curative radiotherapy for patients with cervical relapse of differentiated thyroid carcinoma
CONCLUSION: Salvage cervical radiation therapy was associated with a locoregional control of 66.7% at 2years with a reasonable toxicity rate. Carboplatin association with radiation therapy did not improve locoregional control nor overall survival in comparison with radiotherapy alone.PMID:34253422 | DOI:10.1016/j.canrad.2021.06.013
Source: Cancer Radiotherapie - July 13, 2021 Category: Cancer & Oncology Authors: P Giraud E Blais A Jouinot J Wasserman F M énégaux L Leenhardt P Maingon J-M Simon Source Type: research