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Specialty: Neurology
Procedure: Perfusion
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Total 1377 results found since Jan 2013.
Perfusion Deficits in Different Mechanisms of Two Subtypes of Acute Stroke with Diffusion MRI confirmation
Conclusion: CTP has high specificity in identifying BAD. Compromised perfusion deficits are more presented in BAD patients compared with LI. CT perfusion imaging may be useful for determining the clinical significance of perfusion abnormalities in BAD occurrence.PMID:36588332 | DOI:10.2174/1567202620666221230141102
Source: Current Neurovascular Research - January 2, 2023 Category: Neurology Authors: Cuiting Zhu Wei Qin Wenli Hu Source Type: research
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats
Cerebral ischemia ‒reperfusion injury (CIRI) refers to the phenomenon that structural damage and dysfunction of the brain are further aggravated when blood perfusion is restored after cerebral ischemia for a certain time, which mainly causes apoptosis or necrosis of nerve cells.1 CIRI will result in severe cognitiv e and motor dysfunction.2,3 The current treatments are mainly thrombolysis, intervention, nutritional nerve, and rehabilitation training, but they cannot completely restore the neurological function of patients.
Source: Journal of Stroke and Cerebrovascular Diseases - December 29, 2022 Category: Neurology Authors: Xiuxian Gao, Fei Chen, Xinqi Xu, Jinfeng Liu, Fuxing Dong, Yaping Liu Source Type: research
Visual suppression of vestibulo-ocular reflex in patients treated with carotid artery revascularization: A potential biomarker for cerebral perfusion
Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for ischemic stroke prevention in patients with carotid artery stenosis. However, the beneficial effects of CEA/CAS for cerebral hypoperfusion due to carotid artery stenosis have yet to be fully established. As dizziness is a common symptom in patients with carotid artery stenosis, we aimed to evaluate the effects of CEA/CAS on cerebral function in patients with carotid artery stenosis, using equilibrium function tests.
Source: Journal of the Neurological Sciences - December 25, 2022 Category: Neurology Authors: Shigeta Miyake, Koji Takahashi, Yasunobu Nakai, Yu Amano, Ryoo Yamamoto, Kazumitsu Amari, Hiroya Hara, Ken Johkura Source Type: research
Modelling the Long-Term Health Outcome and Costs of Thrombectomy in Treating Stroke Patients with Large Ischaemic Core: Comparison between Clinical Trials and Real-World Data
Conclusions: Our results highlight the potential gaps when implementing an effective intervention in the real world and the importance of the rigorous selection of large infarct core patients for EVT.Cerebrovasc Dis
Source: Cerebrovascular Diseases - December 14, 2022 Category: Neurology Source Type: research
More is less: Effect of ICF-based early progressive mobilization on severe aneurysmal subarachnoid hemorrhage in the NICU
DiscussionWe conclude that the ICF-based early progressive mobilization protocol is an effective and feasible intervention tool. For validity, more mobilization interventions might lead to less pneumonia, duration of mechanical ventilation and length of stay for patients with severe aSAH in the NICU, Moreover, it is necessary to pay attention over potential adverse events (especially line problems), although we did not find serious safety events.
Source: Frontiers in Neurology - December 14, 2022 Category: Neurology Source Type: research
Stroke and Neurogenesis: Bridging Clinical Observations to New Mechanistic Insights from Animal Models
AbstractStroke was the 2nd leading cause of death and a major cause of morbidity. Unfortunately, there are limited means to promote neurological recovery post-stroke, but research has unearthed potential targets for therapies to encourage post-stroke neurogenesis and neuroplasticity. The occurrence of neurogenesis in adult mammalian brains, including humans, was not widely accepted until the 1990s. Now, adult neurogenesis has been extensively studied in human and mouse neurogenic brain niches, of which the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus are best studied. Numerous oth...
Source: Translational Stroke Research - December 3, 2022 Category: Neurology Source Type: research
Prediction of cerebral hyperperfusion following carotid endarterectomy using intravoxel incoherent motion magnetic resonance imaging
One of the risk factors for cerebral hyperperfusion following carotid endarterectomy (CEA) is a chronic reduction in cerebral perfusion pressure due to internal carotid artery (ICA) stenosis, which is clinically detected as increased cerebral blood volume (CBV). The perfusion fraction (f) is one of the intra-voxel incoherent motion (IVIM) parameters obtained using magnetic resonance (MR) imaging that theoretically reflects CBV. The present study aimed to determine whether preoperative IVIM-f on MR imaging predicts development of cerebral hyperperfusion following CEA.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2022 Category: Neurology Authors: Tatsuhiko Takahashi, Ikuko Uwano, Yosuke Akamatsu, Kohei Chida, Masakazu Kobayashi, Kenji Yoshida, Shunrou Fujiwara, Yoshitaka Kubo, Makoto Sasaki, Kuniaki Ogasawara Source Type: research
Cerebral perfusion imaging predicts final infarct volume after basilar artery thrombectomy
Cerebral perfusion imaging may be used to identify the ischemic core in acute ischemic stroke (AIS) patients with a large vessel occlusion of the anterior circulation; however, perfusion parameters that predict the ischemic core in AIS patients with a basilar artery occlusion (BAO) are poorly described. We determined which cerebral perfusion parameters best predict the ischemic core after successful endovascular thrombectomy (EVT) in BAO patients.
Source: Journal of Stroke and Cerebrovascular Diseases - November 23, 2022 Category: Neurology Authors: Nicole Yuen, Michael Mlynash, Andrea O'Riordan, Maarten Lansberg, Soren Christensen, Carlo W. Cereda, Giovanni Bianco, Dan-Victor Giurgiutiu, Fana Alemseged, Marco Pileggi, Bruce Campbell, Gregory W. Albers, Jeremy J. Heit Source Type: research
Human-Derived Hair Follicle Stem Cells and Hydrogen Sulfide on Focal Cerebral Ischemia Model: A Comparative Evaluation of Radiologic, Neurobehavioral and Immunohistochemical Results
In conclusion, intracerebral HFBSC treatment after 24 hour of ischemic stroke may be an effective way to reduce the cranial infarct volume, whereas H2S treatment alone or in combination with HFBSC may not be sufficient for ischemic brain injury.PMID:36410427 | DOI:10.1016/j.brainres.2022.148170
Source: Brain Research - November 21, 2022 Category: Neurology Authors: Cetin Genc Alican Tahta Ece Erdag Ilyas Dolas Selim Sahin Erdal Karaoz Yavuz Aras Pulat Akin Sabanci Source Type: research
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy
In conclusion, our results suggest that activation of the cGAS-STING pathway exacerbates CIRI at the early stage of CIR, which may be achieved by mediating NCOA4-mediated ferritinophagy.PMID:36343680 | DOI:10.1016/j.expneurol.2022.114269
Source: Experimental Neurology - November 7, 2022 Category: Neurology Authors: Bingyu Li Wei Wang Yanan Li Su Wang Hengjuan Liu Zhongyuan Xia Wenwei Gao Bo Zhao Source Type: research
Radiomics features of DSC-PWI in time dimension may provide a new chance to identify ischemic stroke
This study retrospectively analyzed 80 DSC-PWI data of 56 patients with ischemic stroke from 2013 to 2016. For exploring features in HA and NA,13 feature sets (Fmethod) were obtained from different feature selection algorithms. Furthermore, these 13 Fmethod were validated in identifying HA and NA and distinguishing the proportion of ischemic lesions in brain tissue. In identifying HA and NA, the composite score (CS) of the 13 Fmethod ranged from 0.624 to 0.925. FLasso in the 13 Fmethod achieved the best performance with mAcc of 0.958, mPre of 0.96, mAuc of 0.982, mF1 of 0.959, and mRecall of 0.96. As to classifying the pro...
Source: Frontiers in Neurology - November 4, 2022 Category: Neurology Source Type: research
Medical management of cerebral edema in large hemispheric infarcts
Acute ischemic stroke confers a high burden of morbidity and mortality globally. Occlusion of large vessels of the anterior circulation, namely the intracranial carotid artery and middle cerebral artery, can result in large hemispheric stroke in ~8% of these patients. Edema from stroke can result in a cascade effect leading to local compression of capillary perfusion, increased stroke burden, elevated intracranial pressure, herniation and death. Mortality from large hemispheric stroke is generally high and surgical intervention may reduce mortality and improve good outcomes in select patients. For those patients who are no...
Source: Frontiers in Neurology - November 4, 2022 Category: Neurology Source Type: research
