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Specialty: Drugs & Pharmacology
Procedure: Angiography

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Total 49 results found since Jan 2013.

Insulin-treated versus noninsulin-treated diabetes and risk of ischemic stroke in patients with atrial fibrillation.
CONCLUSION: In patients with AF, DM increases the risk of ischemic stroke, regardless of treatment. PMID: 33130017 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - October 28, 2020 Category: Drugs & Pharmacology Authors: Jensen T, Olesen KKW, Caterina, Würtz M, Kristensen SD, Maeng M Tags: Vascul Pharmacol Source Type: research

Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke
Conclusion Our results suggested the potential protective and repair-promoting effects of TSTT on grey and white matter from damage induced by ischemia. This study provides a modern pharmacological basis for the application of TSTT in managing ischemic stroke. Graphical abstract
Source: Journal of Ethnopharmacology - January 12, 2018 Category: Drugs & Pharmacology Source Type: research

Thrombolysis in acute stroke without angiographically documented occlusion.
CONCLUSIONS: IAT using UK can be a safe and efficacious therapy for the treatment of acute ischemic stroke in patients without angiographic occlusion. Approximately 75% of these patients had a favorable clinical outcome and thrombolysis-related symptomatic hemorrhage was low. PMID: 28429356 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 22, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Dabigatran Reversal with Idarucizumab Preceding Thrombolysis in an Octogenarian Patient with Chronic Kidney Disease and Acute Stroke: a Case Report.
CONCLUSION: Our case showed the effectiveness and safety of giving Idarucizumab followed by thrombolysis in Dabigatran-treated atrial fibrillation with ischemic stroke. Based on this case, the procedure can be performed in an elderly population with chronic kidney disease when administered close to the limit of threshold for thrombolysis. PMID: 32778345 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - August 6, 2020 Category: Drugs & Pharmacology Authors: Laxamana LC, Co COC, Yu JRT, Mojica CV, Iboleon-Dy MAM, Domingo AMC, Ilano KCS, Macrohon-Valdez MCZ Tags: Clin Ther Source Type: research

Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke
In conclusion, C21 prevented cognitive impairment after stroke, likely through a mechanism involving vascular protection and restoration.PMID:34481068 | DOI:10.1016/j.vph.2021.106904
Source: Vascular Pharmacology - September 4, 2021 Category: Drugs & Pharmacology Authors: Wael Eldahshan Mohammed A Sayed Mohamed E Awad Heba A Ahmed Ellen Gillis Waleed Althomali Bindu Pillai Abdulkarim Alshammari Ladonya Jackson Guangkuo Dong Jennifer C Sullivan Marion A Cooley Mohammed Elsalanty Adviye Ergul Susan C Fagan Source Type: research

Alteplase for acute ischemic stroke after heparin reversal with protamine – a case report and review
ConclusionsGiven the lack of adverse events associated with IV alteplase in our patient, we advocate cautious evaluation for potential reversal of acutely administered anticoagulation to facilitate alteplase administration in severely disabled patients who are not eligible for mechanical intervention, and who would have been excluded from definitive AIS treatment.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 25, 2017 Category: Drugs & Pharmacology Authors: Gabriel V. Fontaine, Shawn M. Smith Tags: Case Report Source Type: research

Alteplase for Acute Ischemic Stroke after Heparin Reversal with Protamine: A Case Report and Review
We describe the first reported case of a patient receiving full‐dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73‐year‐old man presented with AIS. He was treated with IV heparin, tirofiban, loading‐dose prasugrel, and aspirin before percutaneous coronary intervention (PCI) for placement of a right coronary artery stent. One hour following PCI, he abruptly developed left hemiparesis and dysphagia. The National Institutes of Health Stroke Scale was 12, and activated partial thromboplastin time (aPTT) was longer than 150 seconds. Head computed tomography (CT) showed no acute patholog...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 4, 2017 Category: Drugs & Pharmacology Authors: Gabriel V. Fontaine, Shawn M. Smith Tags: Case Report Source Type: research

Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after thalamic hemorrhage: A case report.
Authors: Morinaga Y, Nii K, Sakamoto K, Inoue R, Mitsutake T, Hanada H Abstract Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Some studies have suggested that gabapentin may improve the symptoms of PSH. To our knowledge, this is the first case report demonstrating the efficacy of trazodone fo...
Source: Drug Discoveries and Therapeutics - July 23, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Safety of intravenous thrombolysis and mechanical thrombectomy in bilateral posterior cerebral artery territory infarction
CONCLUSION: Even if there is no randomized controlled trial to compare the effectiveness and safety of mechanical thrombectomy (MT) to intravenous thrombolysis in patients with posterior circulation occlusion, the good outcome of this case encourages combined stroke treatments in posterior circulation stroke, even in case of mild but disabling neurological deficits.PMID:34629044 | DOI:10.2174/1574886316666211008140212
Source: Current Drug Safety - October 11, 2021 Category: Drugs & Pharmacology Authors: Maurizio Acampa Francesca Guideri Sandra Bracco Rossana Tassi Carlo Domenichelli Pietro Enea Lazzerini Samuele Cioni Giuseppe Martini Source Type: research

Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient.
Abstract Cobb Syndrome (Spinal Arteriovenous Metameric Syndrome 1-31 (SAMS 1-31)) is a rare, non-hereditary disorder. Approximately 100 cases of CS have been described to date. The actual incidence may be much higher since only symptomatic patients were documented. In particular, post mortem studies suggest a possibly higher incidence of this syndrome. The main clinical manifestations of this syndrome include skin stains of vascular nature on the torso, in combination with spinal vascular malformations localized in one and the same metameric or spinal segment. A rare diagnosis of this syndrome in patients over 18 ...
Source: CNS and Neurological Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Authors: Putilina M, Teplova N, Dvornikov A Tags: CNS Neurol Disord Drug Targets Source Type: research

Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient
CNS Neurol Disord Drug Targets. 2021 Feb 17. doi: 10.2174/1871527320666210218083550. Online ahead of print.ABSTRACTCobb Syndrome (Spinal Arteriovenous Metameric Syndrome 1-31 (SAMS 1-31)) is a rare, non-hereditary disorder. Approximately 100 cases of CS have been described to date. The actual incidence may be much higher since only symptomatic patients were documented. In particular, post mortem studies suggest a possibly higher incidence of this syndrome. The main clinical manifestations of this syndrome include skin stains of vascular nature on the torso, in combination with spinal vascular malformations localized in one...
Source: CNS and Neurological Disorders Drug Targets - February 19, 2021 Category: Drugs & Pharmacology Authors: Marina Putilina Nataliya Teplova Anton Dvornikov Source Type: research

Cerebral Vasospasm following Subarachnoid Haemorrhage.
Abstract Cerebral vasospasm is a common and serious complication of aneurysmal subaracnoid haemorrhage. Despite the improvements in treatment of aneurysmal subarachnoid haemorrhage (aSAH), cerebral vasospasm complicating aSAH has remained the main cause of morbidity and mortality. Subarachnoid haemorrhage (SAH)-induced vasospasm is a complex entity caused by vasculopathy, impaired autoregulation, and hypovolemia, causing a regional reduction of cerebral brain perfusion which can then induce ischemia. Cerebral vasospasm can present either asymptomatically detected only radiologically or symptomatically (delayed isc...
Source: CNS and Neurological Disorders Drug Targets - February 4, 2013 Category: Drugs & Pharmacology Authors: Kühn AL, Balami JS, Grunwald IQ Tags: CNS Neurol Disord Drug Targets Source Type: research

Acute pulmonary emboli in a patient on long-term dabigatran therapy.
CONCLUSIONS: Our patient developed acute bilateral PE despite receiving long-term anticoagulation with dabigatran. While it is possible that patient-specific factors resulted in reduced dabigatran exposure and efficacy, conclusions cannot be made. PMID: 23535815 [PubMed - in process]
Source: The Annals of Pharmacotherapy - April 1, 2013 Category: Drugs & Pharmacology Authors: Rafferty JA, Prom R, Kujawski SZ Tags: Ann Pharmacother Source Type: research