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Procedure: Liver Transplant

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Total 197 results found since Jan 2013.

Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage. Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored ...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news

E-260 Bilateral cerebral arteriovenous shunting through pial and perforating vessels with multiple strokes and intraparenchymal hemorrhages in a patient with hepatopulmonary syndrome
This study presents a unique case of a 54-year-old male patient with a history of stroke, liver cirrhosis, portal vein thrombosis, hypertension, diabetes, and bladder cancer, who experienced multiple episodes of intracranial hemorrhages, stroke and worsening confusion over the past five years. The patient‘s clinical presentation raised suspicion for an underlying occult vasculopathy. Digital subtraction angiography (DSA) revealed multiple curvilinear, irregular, bilateral pial vessels with early high-flow arteriovenous shunting, consistent with vascular shunting that is associated with liver cirrhosis. The patient&ls...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Aljeradat, B., Koneru, M., Oliveira, R., Shaikh, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Lung transplant of extrahospitalary donor after cardiac death
The objective of this study is to describe the results of lung transplantation of after cardiac death program, specifically the section regarding lung extraction donation. Twenty potential lung donors were obtained during the study. Most patients were male (19 cases), with a mean age of 42 years (36.5-49.5 years). A total of 33 lungs were donated (18 right and 15 left lungs). Most extractions were multiorganic (19 cases). One liver, 19 kidneys, 2 pancreas, and 19 corneas were obtained from these donors; bone tissue was obtained from all donors. The transplantation was bipulmonary in 13 cases and unipulmonary in 7. Thirty d...
Source: The American Journal of Emergency Medicine - March 5, 2013 Category: Emergency Medicine Authors: Alonso A. Mateos Rodríguez, José Maria Navalpotro Pascual, Francisco del Río Gallegos Tags: Brief Reports Source Type: research

Neurological Complications Prevalence and Long-Term Survival After Liver Transplantation
Conclusions: Neurological complications led to longer hospital stays with greater early morbidity and mortality. Knowledge of these complications appears to be extremely important for the multidisciplinary transplantation team to decrease its prevalence as well as to diagnose and treat early.
Source: Transplantation Proceedings - April 1, 2013 Category: Transplant Surgery Authors: R.C. Colombari, E.C. de Ataíde, E.Y. Udo, A.L.E. Falcão, L.C. Martins, I.F.S.F. Boin Tags: Liver Transplantation Source Type: research

Systematic bias in surgeons' predictions of the donor‐specific risk of liver transplant graft failure
In conclusion, transplant surgeons vary widely in their predictions of the donor‐specific risk of graft failure, and they demonstrate a systematic bias toward inaccurately low estimates of graft failure, particularly for higher risk organs. Liver Transpl, 2013. © 2013 AASLD.
Source: Liver Transplantation - June 19, 2013 Category: Transplant Surgery Authors: Michael L. Volk, Meghan Roney, Robert M. Merion Tags: Original Article Source Type: research

Stem cells: what happened to the radical breakthroughs?
Much was promised in the late 1990s, but the challenge of advances such as growing whole human organs has been difficult to deliverIt's 1998 and science is taking big strides. The first cloned mammal, Dolly the Sheep, has just had her first lamb; the first robotically assisted heart surgery has been completed; Furbys have hit the shelves. In a bold announcement, biomedical engineer Professor Michael Sefton declared that within 10 years, scientists would have grown an entire heart, fit for transplant. "We're shooting big," he said. "Our vision is that we'll be able to pop out a damaged heart and replace it as easily as you ...
Source: Guardian Unlimited Science - August 10, 2013 Category: Science Authors: Simon Roach Tags: Biology Medical research Features Stem cells The Observer Science Source Type: news

Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats.
Abstract Intra-arterial (i.a.) delivery of bone marrow-derived mesenchymal stem cells (BMMSCs) has shown potential as a minimally invasive therapeutic approach for stroke. The aim of the present study was to determine the whole-body biodistribution and clearance of technetium-99m ((99m)Tc)-labeled rat and human BMMSCs after i.a. delivery in a rat model of transient middle cerebral artery occlusion (MCAO) using single photon emission computed tomography (SPECT). Our hypothesis was that xenotransplantation has a major impact upon the behavior of cells. Male RccHan:Wistar rats were subjected to sham-operation or MCAO...
Source: Cell Transplantation - March 3, 2014 Category: Cytology Authors: Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J Tags: Cell Transplant Source Type: research

Quality of Life in Liver Transplant Patients with Neurologic Complications. (P4.031)
Conclusions: Our analysis shows that neurological complications worsen the quality of life of liver transplant patients. Especially regarding perception of health, ability to function independently due to physical and mental health limitations. Pain is a limiting condition in this group. Transplant patients who suffer neurological complications should be carefully followed up to reduce the impact on quality of life, in order to promote the ultimate goal of transplant.Disclosure: Dr. Gonzalez Toledo has nothing to disclose. Dr. Calle has received personal compensation for activities with UCB Pharma. Dr. Pagani Cassara has n...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gonzalez Toledo, M., Calle, A., Pagani Cassara, F., Tamargo, A., Thomson, A., Nadile, D., Gruz, F., Sinay, V. Tags: General Neurology III Source Type: research

Utilization of Bioreactance Technique as Indicator for Preload Responsiveness During Living Donor Liver Donation
Conclusions: Our study has shown that SVV measured from the bioreactance technique is a poor indicator for monitoring preload responsiveness during LDLD.
Source: Transplantation Proceedings - April 1, 2014 Category: Transplant Surgery Authors: T.-W. Lin, C.-F. Luo, C.-C. Lin, W.-C. Lee, B.-C. Su Tags: Liver Transplantation Source Type: research

Corrected Flow Time Is a Good Indicator for Preload Responsiveness During Living Donor Liver Donation
Conclusions: FTc is a noninvasive, easily obtainable, and essentially good preload indicator during LDLD.
Source: Transplantation Proceedings - April 1, 2014 Category: Transplant Surgery Authors: B.-C. Su, C.-F. Luo, W.-Y. Chang, W.-C. Lee, C.-C. Lin Tags: Liver Transplantation Source Type: research

Coagulation management with factor concentrates in liver transplantation: a single-center experience.
CONCLUSION: In LT, ROTEM-guided treatment with fibrinogen concentrate and/or PCC did not appear to increase the occurrence of thrombosis and ischemic events compared to patients who did not receive these concentrates. PMID: 24827116 [PubMed - as supplied by publisher]
Source: Transfusion - May 14, 2014 Category: Hematology Authors: Kirchner C, Dirkmann D, Treckmann JW, Paul A, Hartmann M, Saner FH, Görlinger K Tags: Transfusion Source Type: research

High early cardiovascular mortality following liver transplantation
Abstract Cardiovascular disease (CVD) contributes to excess long‐term mortality after liver transplantation (LT), however little is known about early post‐operative CVD mortality in the current era. In addition, there is no model to predict early post‐operative CVD mortality across centers. We analyzed adult recipients of primary LT in the Organ Procurement and Transplantation Network (OPTN) database between February 2002 and December 2012 to assess prevalence and predictors of early (30‐day) CVD mortality, defined as death from arrhythmia, heart failure, myocardial infarction, cardiac arrest, thromboembolism, and/...
Source: Liver Transplantation - July 5, 2014 Category: Transplant Surgery Authors: Lisa B. VanWagner, Brittany Lapin, Josh Levitsky, John T. Wilkins, Michael M. Abecassis, Anton I. Skaro, Donald M. Lloyd‐Jones Tags: Original Article Source Type: research

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting.
CONCLUSIONS: Medical toxicologists have some reservation in recommending solid organs for transplantation from deaths from cocaine and carbon monoxide. Given the decrease in potential organ donors from typical methods of death, further work is needed to promote organ donation in deaths related to acute poisoning. PMID: 25023224 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - July 15, 2014 Category: Toxicology Authors: Wood DM, Chan WL, Dargan PI Tags: J Med Toxicol Source Type: research

Effects of edaravone, a radical scavenger, on hepatocyte transplantation
ConclusionsEdaravone administration during HTx can suppress apoptosis near the transplanted cells, increasing engraftment. These studies indicate its potential usefulness for future clinical application.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - September 10, 2014 Category: Gastroenterology Authors: Chihiro Hayashi, Masahiro Ito, Ryoutaro Ito, Akiko Murakumo, Naoki Yamamoto, Noriko Hiramatsu, Ira J. Fox, Akihiko Horiguchi Tags: Original Article Source Type: research

High early cardiovascular mortality after liver transplantation
In conclusion, we provide the first multicenter prognostic model for the prediction of early post‐LT CVD death, the most common cause of early post‐LT mortality in the current transplant era. However, evaluations of additional CVD‐related variables not collected by the OPTN are needed in order to improve the model's accuracy and potential clinical utility. Liver Transpl, 2014. © 2014 AASLD.
Source: Liver Transplantation - October 24, 2014 Category: Transplant Surgery Authors: Lisa B. VanWagner, Brittany Lapin, Josh Levitsky, John T. Wilkins, Michael M. Abecassis, Anton I. Skaro, Donald M. Lloyd‐Jones Tags: Original Article Source Type: research