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Specialty: Allergy & Immunology

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Total 749 results found since Jan 2013.

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke
ConclusionThis systematic analysis not only helps in the understanding of the changes in the gene expression profiles of both the brain and skull with ischemic injury but also reveals the association of the tumor immune microenvironment and cell death with ischemic stroke.
Source: Frontiers in Immunology - December 20, 2022 Category: Allergy & Immunology Source Type: research

Role of IL-17A in different stages of ischemic stroke
Int Immunopharmacol. 2023 Apr;117:109926. doi: 10.1016/j.intimp.2023.109926. Epub 2023 Mar 11.ABSTRACTInterleukin-17A (IL-17A) plays an important role in the progression of ischemic stroke. IL-17A mediates the endothelial inflammatory response, promotes water and sodium retention, and changes the electrophysiological structure of the atrium, accelerating the progression of ischemic stroke risk factors such as atherosclerotic plaques, hypertension, and atrial fibrillation. In the acute phase of ischemic stroke, IL-17A mediates neuronal injury through neutrophil chemotaxis to the site of injury, the induction of neuronal apo...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Xiuping Chen Yi Zhang Qian Ding Yanru He Hui Li Source Type: research

Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Abstract Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and numbe...
Source: Innate Immunity - September 17, 2013 Category: Allergy & Immunology Authors: Palm F, Lahdentausta L, Sorsa T, Tervahartiala T, Gokel P, Buggle F, Safer A, Becher H, Grau AJ, Pussinen P Tags: Innate Immun Source Type: research

Different treatment settings of Granulocyte-Colony Stimulating Factor and their impact on T cell-specific immune response in experimental stroke.
CONCLUSION: A single dose of G-CSF exerted neuroprotective effects in ischemic stroke, which were less pronounced after daily G-CSF application. Both treatment strategies inhibited stroke-induced reduction of T lymphocytes in peripheral blood, which may have contributed to the reduction of infarct size. PMID: 24333341 [PubMed - as supplied by publisher]
Source: Immunology Letters - December 12, 2013 Category: Allergy & Immunology Authors: Dietel B, Cicha I, Achenbach S, Kollmar R, Garlichs C, Tauchi M Tags: Immunol Lett Source Type: research

Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke.
Authors: Ruhnau J, Schulze J, Dressel A, Vogelgesang A Abstract Immune cells can significantly predict and affect the clinical outcome of stroke. In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunological mechanisms underlying these effects are poorly understood. Neutrophils are the first cells to invade injured tissue following focal brain ischemia. In these conditions, their proinflammatory properties enhance tissue damage and may promote ischemic incidences by inducing thrombus formation. Therefore, they constit...
Source: Journal of Immunology Research - March 24, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Increased ischemic stroke, acute coronary artery disease and mortality in patients with granulomatosis with polyangiitis and microscopic polyangiitis.
CONCLUSION: AAV have a significantly increased risk of mortality, ischemic stroke, and coronary artery disease. PMID: 30236485 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - September 17, 2018 Category: Allergy & Immunology Authors: Mourguet M, Chauveau D, Faguer S, Ruidavets JB, Béjot Y, Ribes D, Huart A, Alric L, Balardy L, Astudillo L, Adoue D, Sailler L, Pugnet G Tags: J Autoimmun Source Type: research

Therapeutic effects of modafinil in ischemic stroke; possible role of NF- κB downregulation.
Conclusion: Our findings demonstrate a promising therapeutic effect of modafinil for animal models of stroke. PMID: 31542978 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - September 25, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques.
This study provides a systematic, wide view of the immune components in the brain and peripheral organs for a deep understanding of the immune response after ischemic stroke. PMID: 32908941 [PubMed - in process]
Source: Journal of Immunology Research - September 12, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Interleukin-17 and ischemic stroke.
Abstract Interleukin-17 (IL-17) is a cytokine family that includes 6 members, IL-17A through IL-17F, most of them are reported to have pro-inflammatory role. Through binding to their receptors (IL-17Rs), IL-17 activates the intracellular signaling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS). Ischemic stroke is a complex pathophysiological process mainly caused by regional cerebral ischemia. Inflammatory factors contribute to the physiological process of stroke that leads to poor prognosis. IL-17 plays a crucial role in promoting inflamm...
Source: Immunology - September 15, 2020 Category: Allergy & Immunology Authors: Zhang Q, Liao Y, Liu Z, Dai Y, Li Y, Li Y, Tang Y Tags: Immunology Source Type: research

Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State
Cerebral-cardiac syndrome (CCS) refers to cardiac dysfunction following varying brain injuries. Ischemic stroke is strongly evidenced to induce CCS characterizing as arrhythmia, myocardial damage, and heart failure. CCS is attributed to be the second leading cause of death in the post-stroke stage; however, the responsible mechanisms are obscure. Studies indicated the possible mechanisms including insular cortex injury, autonomic imbalance, catecholamine surge, immune response, and systemic inflammation. Of note, the characteristics of the stroke population reveal a common comorbidity with diabetes. The close and causative...
Source: Frontiers in Immunology - August 27, 2021 Category: Allergy & Immunology Source Type: research

Biological Functions and Regulatory Mechanisms of Hypoxia-Inducible Factor-1 α in Ischemic Stroke
Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a major contributor to death or disability worldwide and has become a heavy societal and clinical burden. To date, effective treatments for ischemic stroke are limited, and innovative therapeutic methods are urgently needed. Hypoxia inducible factor-1α (HIF-1α) is a sensitive regulator of oxygen homeostasis, and its expression is rapidly induced after hypoxia/ischemia. It plays an extensive role in the pathophysiology of stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, and blood brain barrier ...
Source: Frontiers in Immunology - December 13, 2021 Category: Allergy & Immunology Source Type: research

The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
Int Immunopharmacol. 2022 May 4;109:108733. doi: 10.1016/j.intimp.2022.108733. Online ahead of print.ABSTRACTMicroglia are the earliest activated and the longest lasting immune cells after stroke, and they participate in almost all the pathological reactions after stroke. However, their regulatory mechanism has not been fully elucidated. Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor that is mainly expressed in microglia of the central nervous system. The receptor plays an important role in regulating microglia energy metabolism and phenotypic transformation. At present, TREM2 has been ...
Source: International Immunopharmacology - May 7, 2022 Category: Allergy & Immunology Authors: Wen-Yu Ma Sha-Sha Wang Qing-Lin Wu Xin Zhou Shi-Feng Chu Nai-Hong Chen Source Type: research

Role of Immune and Inflammatory Mechanisms in Stroke: A Review of Current Advances
Stroke accounts for a large proportion of morbidity and mortality burden in China. Moreover, there is a high prevalence of the leading risk factors for stroke, including hypertension and smoking. Understanding the underlying mechanisms and developing effective therapeutic interventions for patients with stroke is a key imperative. The pathophysiology of stroke involves a complex interplay between the immune and inflammatory mechanisms. Focal brain inflammation triggered by neuronal cell death and the release of factors such as damage-associated molecular patterns can further exacerbate neuronal injury; in addition, impairm...
Source: Neuroimmunomodulation - May 31, 2022 Category: Allergy & Immunology Source Type: research