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Specialty: Neurology
Therapy: Hormone Replacement Therapy

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Total 19 results found since Jan 2013.

Worsening Severity of Migraines in Current Users of Hormone Replacement Therapy Correlates to Increased Risk of Ischemic Stroke (I2.011)
Conclusions: Current HRT users that have an increase in severity of one grade or more of migraines are shown to have an increased risk of ischemic strokes.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Poster Presentations Source Type: research

Stroke in Women
This article reviews sex differences in stroke risk and presentation, with a particular emphasis on the unique risk factors women experience throughout the lifespan. RECENT FINDINGS Although prior studies suggested women have worse outcomes after stroke, it is now clear that age, prestroke functional status, and comorbidities explain many of the differences between men and women in stroke severity, functional outcomes, and mortality. Several meta-analyses and large cohort studies have evaluated the risk factors for women related to reproductive factors and found that fewer years between menarche and menopause, pregnancy...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Previous Use of Unopposed Estrogen Hormone Replacement Therapy Continues to Cause Increased Risk for Future Ischemic Strokes (S4.008)
Conclusions:Previous use of unopposed estrogen HRT continues to increase risk for ischemic stroke after they are discontinued, although combination of estrogen and progesterone HRT do no continue to have a significantly increased risk. Future prospective studies are required to further investigate these correlations.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Worsening Severity of Migraines in Current Users of Hormone Replacement Therapy Correlates to Increased Risk of Ischemic Stroke (P4.118)
Conclusions: Current HRT users that have an increase in severity of one grade or more of migraines are shown to have an increased risk of ischemic strokes.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Headache: Imaging and Other Source Type: research

Cryptogenic stroke in a young patient with heart disease and kidney failure.
CONCLUSIONS: Fabry's disease must be suspected in young males with heart disease, stroke or peripheral neuropathy, skin lesions, kidney failure and a history of cases in the family. Hormone replacement therapy must be established at an early stage, as it can improve the prognosis. PMID: 28497441 [PubMed - in process]
Source: Revista de Neurologia - May 13, 2017 Category: Neurology Authors: Oyanguren B, Segoviano R, Alegria E, Besada E, Gonzalez-Salaices M, Eimil-Ortiz M, Lopez de Silanes C Tags: Rev Neurol Source Type: research

Hormone Replacement Therapy and Adverse Outcomes in Women With Atrial Fibrillation: An Analysis From the Atrial Fibrillation Follow-Up Investigation of Rhythm Management Trial Brief Reports
Conclusions— HRT does not independently predict mortality, thromboembolism, or bleeding in a large cohort of women with atrial fibrillation.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Apostolakis, S., Sullivan, R. M., Olshansky, B., Lip, G. Y. H. Tags: Other Treatment Brief Reports Source Type: research

Worsening Migraine During HRT Tied to Increased Stroke Risk Worsening Migraine During HRT Tied to Increased Stroke Risk
Women who have worsening migraines while receiving hormone replacement therapy are at increased risk for ischemic stroke, new research suggests. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - February 18, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Previous Use of Unopposed Estrogen Hormone Replacement Therapy Continues to Cause Increased Risk for Future Ischemic Strokes (I5.011)
Conclusions:Previous use of unopposed estrogen HRT continues to increase risk for ischemic stroke after they are discontinued, although combination of estrogen and progesterone HRT do no continue to have a significantly increased risk. Future prospective studies are required to further investigate these correlations.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Sex-related Factors in Neurological Disease Poster Presentations Source Type: research

Transient ischemic attacks in post-menopausal women with history of migraines have lower risk for subsequent ischemic strokes (P2.306)
CONCLUSIONS: The risk of ischemic stroke is lower following TIA in women with migraine history (compared with those without migraine) suggesting potentially different pathophysiology in such women.Disclosure: Dr. Rahman has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rahman, H., Malik, A., Thomas, A., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Carotid plaque thickness is positively associated with decreased bone mineral density (P2.264)
CONCLUSIONS: This study showed that increased maximum carotid IMT/plaque value is significantly associated with decreased BMD after controlling for the effects of age, gender, and BMI in acute stroke patients. Study Supported by: NoneDisclosure: Dr. Han has nothing to disclose. Dr. Park has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Han, S. W., Park, J. H., Park, J. H., Lee, J. Y., Lee, K.-Y. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease and IMT Source Type: research

Beyond contraception and hormone replacement therapy: advancing Nestorone to a neuroprotective drug in the clinic.
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability...
Source: Brain Research - October 12, 2018 Category: Neurology Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Tags: Brain Res Source Type: research

Reprint of: Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic.
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability...
Source: Brain Research - June 14, 2019 Category: Neurology Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Tags: Brain Res Source Type: research

A Post-Hoc Assessment of Current Hormone Therapy on Revascularization Risk in Women: The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) (P03.168)
CONCLUSIONS: We found that women on current HRT have lower periprocedural risk associated with CAS or CEA than non-users, but little difference in risk after the procedural period. The mechanism for this unexpected finding is elusive. We urge caution in the interpretation of this post-hoc observation and encourage replication or refutation by other revascularization studies with similar data.Disclosure: Dr. Mackey has nothing to disclose. Dr. Lutsep has received personal compensation for serving on Consultant/Advisory Boards for Concentric Medical/Stryker, Co-Axia, and AGA Medical. Dr. Lutsep has received personal compensa...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mackey, A., Lutsep, H., Milot, G., Voeks, J., Howard, V., Hughes, S., Tom, M., Longbottom, M., Sheffet, A., Brott, T. Tags: P03 Cerebrovascular Disease III Source Type: research

Sex and Gender Considerations in Episodic Migraine
AbstractPurpose of ReviewWe seek to update readers on recent advances in our understanding of sex and gender in episodic migraine with a two part series. In part 1, we examine migraine epidemiology in the context of sex and gender, differences in symptomatology, and the influence of sex hormones on migraine pathophysiology (including CGRP). In part 2, we focus on practical clinical considerations for sex and gender in episodic migraine by addressing menstrual migraine and the controversial topic of hormone-containing therapies. We make note of data applicable to gender minority populations, when available, and summarize kn...
Source: Current Pain and Headache Reports - June 9, 2022 Category: Neurology Source Type: research

Multiple Cerebral Infarctions in a Patient with Adenomyosis on Hormone Replacement Therapy: A Case Report
A 59-year-old woman was admitted to our hospital because of repeated episodes of bilateral hand weakness. She had a 10-year history of combined estrogen –progestin therapy for menopausal symptoms. Magnetic resonance imaging on admission showed multiple hyperintense lesions in bilateral cerebral and cerebellar cortices on diffusion-weighted imaging. Transesophageal echocardiography showed thrombus formation on the aortic valve and moderate aortic i nsufficiency. Laboratory test demonstrated elevated CA125 (334.8 U/mL) and D-dimer (7.0 µg/mL) levels.
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2016 Category: Neurology Authors: Nanako Hijikata, Yuki Sakamoto, Chikako Nito, Noriko Matsumoto, Arata Abe, Akane Nogami, Takahiro Sato, Hiroyuki Hokama, Seiji Okubo, Kazumi Kimura Tags: Case Studies Source Type: research