Reprint of: Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic.

Reprint of: Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic. Brain Res. 2019 Jun 15;: Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability to reduce infarct sizes and preclude functional impairments in rats subjected to ischemic stroke. This commentary highlights Nestorone's properties as a progestin, its neuroprotective capabilities in animal studies, and how the Tanaka team's findings and previous clinical trials contribute to Nestorone's translation into a therapeutic agent for stroke and other neurological diseases. PMID: 31213288 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionYounger initiation of HRT may be effective in reducing death and cardiac events. However, younger HRT initiators remained at an increased risk of stroke, TIA and systemic embolism and this risk increased as average age increased. Younger menopausal women using HRT to treat vasomotor symptoms do not appear to be at an increased risk of dying or experiencing CHD events.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's abil...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Background: Gender related differences in stroke incidence hallmark the increased observation of women experiencing strokes later in life. Complications of women longevity has accounted for their increased risk of cardiovascular and cerebrovascular diseases. However, the severity of acute ischemic stroke (AIS) outcomes in women remains problematic. Previous studies have reported that women experience more disabilities and have poorer outcomes at three month follow-ups and may be related back to age at the time of stroke. We retrospectively examined 12 months of neurology consults in the Arkansas Stroke Assistance through V...
Source: Circulation: Cardiovascular Quality and Outcomes - Category: Cardiology Authors: Tags: Session Title: Poster Session II Source Type: research
Objective:To assess the prolonged risk of ischemic stroke from previous use of hormone replacement therapy (HRT). Background:An increased risk of ischemic strokes has been linked with unopposed estrogen HRT. It has yet to be established whether use of estrogen only HRT in the past continues to cause an increased risk for ischemic strokes. Methods:Using data from the observational component of the Women’s Health Initiative (WHI) [WHI Observational Study (OS)], we analyzed the 93,676 women aged 50-79 years, who participated in the OS over a period of 12±1 years. We compared the outcome of ischemic stroke in part...
Source: Neurology - Category: Neurology Authors: Tags: Health Disparities and Sex Differences in Stroke Source Type: research
Background: Hormone replacement therapy (HRT) is considered a risk factor for migraines. The risk of ischemic stroke may increase as the severity of migraines increases in patients currently using HRT. Methods: We analyzed the data for 82,208 women, aged 50 - 79 years, who were enrolled in the Women’s Health Initiative Study. We determined the risk of ischemic stroke in participants with migraines who had current HRT, past HRT, and no HRT. We further dichotomized participants into those who experienced an increase in migraine severity of one grade or more and participants who experienced no change or a decrease in mi...
Source: Neurology - Category: Neurology Authors: Tags: Headache: Imaging and Other Source Type: research
Objective:To assess the prolonged risk of ischemic stroke from previous use of hormone replacement therapy (HRT). Background:An increased risk of ischemic strokes has been linked with unopposed estrogen HRT. It has yet to be established whether use of estrogen only HRT in the past continues to cause an increased risk for ischemic strokes. Methods:Using data from the observational component of the Women’s Health Initiative (WHI) [WHI Observational Study (OS)], we analyzed the 93,676 women aged 50-79 years, who participated in the OS over a period of 12±1 years. We compared the outcome of ischemic stroke in part...
Source: Neurology - Category: Neurology Authors: Tags: Sex-related Factors in Neurological Disease Poster Presentations Source Type: research
Background: Hormone replacement therapy (HRT) is considered a risk factor for migraines. The risk of ischemic stroke may increase as the severity of migraines increases in patients currently using HRT. Methods: We analyzed the data for 82,208 women, aged 50 - 79 years, who were enrolled in the Women’s Health Initiative Study. We determined the risk of ischemic stroke in participants with migraines who had current HRT, past HRT, and no HRT. We further dichotomized participants into those who experienced an increase in migraine severity of one grade or more and participants who experienced no change or a decrease in mi...
Source: Neurology - Category: Neurology Authors: Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Poster Presentations Source Type: research
Worsening migraines in users of hormone replacement therapy is associated with an increased risk of ischaemic stroke, according to a new study.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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