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Specialty: Hematology
Procedure: Gastroschisis Repair

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Total 23 results found since Jan 2013.

Hemorrhagic Transformation and Stroke Recurrence in Children with Cardiac Disease Receiving Antithrombotic Therapy for Secondary Stroke Prevention
CONCLUSIONS: In spite of the 24% hemorrhagic transformation rate, antithrombotic therapy has a positive risk-balance in certain cardioembolic stroke subgroups, particularly in those with single-ventricle physiology, when accounting for stroke volume.PMID:34152075 | DOI:10.1111/jth.15428
Source: Thrombosis and Haemostasis - June 21, 2021 Category: Hematology Authors: Elizabeth Pulcine Mike Seed Leonardo R Brand ão Mahmoud Slim Sunitha Palasamudram Manohar Shroff Mahendranath Moharir Gabrielle deVeber Nomazulu Dlamini Source Type: research

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
CONCLUSIONS: Heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies. PMID: 32367690 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 3, 2020 Category: Hematology Authors: Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR Tags: J Thromb Haemost Source Type: research

Middle Cerebral Artery Stroke in a Neonate With a Congenital Hypercoagulable Condition Following Repair of an H-type Tracheoesophageal Fistula
This report provides a concise review of the etiology and treatment of stroke and hypercoagulable states in neonates as well as presents the case of a previously undescribed complication of repair of an H-type TEF.
Source: Journal of Pediatric Hematology Oncology - September 30, 2016 Category: Hematology Tags: Original Articles Source Type: research

Human stem cells transplanted into the rat stroke brain migrate to spleen via lymphatic and inflammation pathways.
This study is the first to demonstrate brain-to-periphery migration of stem cells, advancing the novel concept of harnessing the lymphatic system in mobilizing stem cells to sequester peripheral inflammation as a brain repair strategy. PMID: 30514806 [PubMed - as supplied by publisher]
Source: Haematologica - December 4, 2018 Category: Hematology Authors: Xu K, Lee JY, Kaneko Y, Tuazon JP, Vale F, van Loveren H, Borlongan CV Tags: Haematologica Source Type: research

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanis...
Source: Journal of Hematology and Oncology - April 11, 2015 Category: Hematology Authors: Ya-Feng LiLi-Na RenGeng GuoLee CannellaValeria ChernayaSonia SamuelSu-Xuan LiuHong WangXiao-Feng Yang Source Type: research

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery
Angiogenic response is essential for ischemic brain repair. The von Willebrand factor (VWF)–cleaving protease disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) is required for endothelial tube formation in vitro, but there is currently no in vivo evidence supporting a function of ADAMTS13 in angiogenesis. Here we show that mice deficient in ADAMTS13 exhibited reduced neovascularization, brain capillary perfusion, pericyte and smooth muscle cell coverage on microvessels, expression of the tight junction and basement membrane proteins, and accelerated blood-brain barrier (BBB) break...
Source: Blood - July 6, 2017 Category: Hematology Authors: Xu, H., Cao, Y., Yang, X., Cai, P., Kang, L., Zhu, X., Luo, H., Lu, L., Wei, L., Bai, X., Zhu, Y., Zhao, B.-Q., Fan, W. Tags: Plenary Papers, Thrombosis and Hemostasis, Vascular Biology Source Type: research

Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke (CoBIS): Clinical Outcomes From a Phase 1 Study
Background: Over 750,000 patients/year in the US experience a debilitating stroke. Approximately 88% of adult strokes are ischemic, and occur when cerebral blood flow is blocked by a clot or mechanical event. The initial neuroinflammatory response following stroke results in the release of inflammatory mediators which may exacerbate the development of cerebral edema and secondary tissue injury. Preclinical data suggest that cell-based therapy may favorably alter these processes through paracrine signaling that reduces inflammation, promotes angiogenesis, neurogenesis and recruitment of endogenous cell repair mechanisms.
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Joanne Kurtzberg, Jesse D. Troy, Ellen Bennett, Rebecca Durham, Elizabeth J. Shpall, Jonathan Wiese, John Volpi, Samir Belagaje, Daniel Laskowitz Source Type: research

Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke.
In conclusion, local delivery of PLT to the lateral ventricles induces angiogenesis, neurogenesis and neuroprotection and reduces behavioural deficits after brain ischaemia. PMID: 23765126 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 13, 2013 Category: Hematology Authors: Hayon Y, Dashevsky O, Shai E, Varon D, Leker RR Tags: Thromb Haemost Source Type: research

Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke
Approximately 87% of adult strokes are ischemic in etiology, and occur when cerebral blood flow is blocked by a clot or mechanical event. Immediately after the stroke, inflammatory mediators may exacerbate the development of cerebral edema and secondary tissue injury. Cell therapy may favorably alter the natural history of these processes through paracrine signaling that reduces inflammation, promotes angiogenesis, neurogenesis and recruitment of endogenous cell repair mechanisms. We hypothesize that cell therapy using non HLA matched umbilical cord blood (CB) from an unrelated donor would provide benefit by reducing the a...
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Joanne Kurtzberg, Rebecca Durham, Daniel Laskowitz, Andrew E. Balber, Ellen Bennett Tags: Clinical Cellular Therapy Source Type: research

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways.
Abstract PPARγ-achieved neuroprotection in experimental stroke has been explained by the inhibition of inflammatory genes, an action in which 5-LO, Alox5, is involved. In addition, PPARγ is known to promote the expression of CD36, a scavenger receptor that binds lipoproteins and mediates bacterial recognition and also phagocytosis. As phagocytic clearance of neutrophils is a requisite for resolution of the inflammatory response, PPARγ-induced CD36 expression might help to limit inflammatory tissue injury in stroke, an effect in which 5-LO might also be involved. Homogenates, sections, and cellular suspensions w...
Source: Journal of Leukocyte Biology - December 12, 2013 Category: Hematology Authors: Ballesteros I, Cuartero MI, Pradillo JM, de la Parra J, Pérez-Ruiz A, Corbí A, Ricote M, Hamilton JA, Sobrado M, Vivancos J, Nombela F, Lizasoain I, Moro MA Tags: J Leukoc Biol Source Type: research

Nonvitamin K Antagonist Oral Anticoagulants Use in Patients with Atrial Fibrillation and Bioprosthetic Heart Valves/Prior Surgical Valve Repair: A Multicenter Clinical Practice Experience
Semin Thromb Hemost DOI: 10.1055/s-0037-1615261This is an observational study to investigate the efficacy and safety of nonvitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with bioprosthetic valves or prior surgical valve repair in clinical practice. A total of 122 patients (mean age: 74.1 ± 13.2; 54 females) with bioprosthetic heart valve or surgical valve repair and AF treated with NOACs were included in the analysis. The mean CHA2DS2-VASc (Congestive heart failure, Hypertension, Age >75 years, Diabetes mellitus, prior Stroke or transient ischemic attack, Vascular disease) and...
Source: Seminars in Thrombosis and Hemostasis - January 5, 2018 Category: Hematology Authors: Russo, Vincenzo Attena, Emilio Mazzone, Carmine Esposito, Francesca Parisi, Valentina Bancone, Ciro Rago, Anna Nigro, Gerardo Sangiuolo, Raffaele D' Onofrio, Antonio Tags: Original Article Source Type: research

Association between platelet counts and morbidity and mortality after endovascular repair for type B aortic dissection.
This study aimed to assess the association of postoperative platelet counts with early and late outcomes after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD). We retrospectively evaluated 892 patients with TBAD who underwent TEVAR from a prospectively maintained database. Postoperative nadir platelet counts were evaluated as a continuous variable, and a categorical variable (thrombocytopenia), which was defined as platelet count≤ the lowest 10% percentile (108 × 109/l). Multivariable logistic regression analyses were conducted to assess the impact of postoperative thrombocytopenia on e...
Source: Platelets - November 22, 2020 Category: Hematology Tags: Platelets Source Type: research

Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque
Abstract: Introduction: There have been no satisfactory therapies on stabilizing and repairing ruptured plagues nowadays, which are the fundamental causes of acute coronary syndrome (ACS) and stroke. The aim of this study was to investigate the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in stabilizing and repairing ruptured plaques.Materials and Methods: 28 male New Zealand rabbits were randomly divided into 2 groups after establishment of atherosclerotic disrupted plaque model by liquid nitrogen frostbite: MSCs transplantation group and control group. MSCs were isolated, cultured in vitro, and labe...
Source: Thrombosis Research - April 25, 2013 Category: Hematology Authors: Shun-Miao Fang, Da-Yong Du, Yun-Tian Li, Xing-Li Ge, Peng-Tao Qin, Qing-Hua Zhang, Yang Liu Tags: Platelets and Cell Biology Source Type: research

To intervene or not? A man with multidrug-resistant hypertension, endovascular abdominal aneurysm repair, bilateral renal artery stenosis and end-stage renal disease salvaged with renal artery stenting.
We report the case of a 69-year-old man with uncontrolled multidrug-resistant secondary hypertension following a 10 year history of endovascular abdominal aortic aneurysm repair, with suprarenal fixation and concurrent angioplasty with stenting of the left renal artery for atherosclerotic renal disease, and progressive chronic kidney disease. Renal scintigraphy revealed complete loss of the right kidney's and severe reduction of the left kidney's perfusion and function. Following recent evidence and consultation with vascular surgeons regarding the technical difficulties of any procedure, escalation of antihypertensive tre...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research